{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:19:30Z","timestamp":1747149570561,"version":"3.40.5"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T00:00:00Z","timestamp":1697587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["accp1.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Clinical Pharma"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hydrocephalus is a disorder caused by excess fluid accumulation in the brain and results in brain damage with consequent cognitive and physical problems. This condition has no cure; the only treatment is brain surgery. Experimental data indicate that P\u2010glycoprotein (P\u2010gp) plays a crucial role in the pathogenesis of hydrocephalus due to its function in clearing macromolecules from the brain. Numerous medications frequently used are classified as P\u2010gp inducers or inhibitors, and comprehending their effects may aid in attaining improved patient outcomes. Therefore, in this single\u2010center retrospective study, we examined the risk of the need for ventriculoperitoneal shunt placement over 10\u00a0years among 4588 adult patients with hydrocephalus not exposed to any P\u2010gp inhibitors\/inducers or exclusively exposed to either P\u2010gp inhibitors or inducers. Our analysis shows that patients exposed to P\u2010gp inhibitors had a 3.2 times higher risk of requiring ventriculoperitoneal shunt surgery (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.0001). In contrast, the relative risk was not significantly affected (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.07) among those exposed to P\u2010gp inducers. Our findings indicate the need for caution when prescribing P\u2010gp inhibitors to patients with hydrocephalus. Additional studies using larger cohorts are required to confirm whether P\u2010gp inducers in patients with hydrocephalus can mitigate the risk of ventriculoperitoneal shunt.<\/jats:p>","DOI":"10.1002\/jcph.2359","type":"journal-article","created":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T17:23:38Z","timestamp":1695749018000},"page":"371-377","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Do P\u2010glycoprotein Medications Alter the Risk of Ventriculoperitoneal Shunt in Adults with Hydrocephalus?"],"prefix":"10.1002","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4310-3571","authenticated-orcid":false,"given":"Jason R.","family":"Grullon","sequence":"first","affiliation":[{"name":"Norton College of Medicine SUNY Upstate Medical University  Syracuse NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George W.","family":"Koutsouras","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Norton College of Medicine SUNY Upstate Medical University  Syracuse NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nneka F.","family":"Onwumere","sequence":"additional","affiliation":[{"name":"Norton College of Medicine SUNY Upstate Medical University  Syracuse NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David F.","family":"Lehmann","sequence":"additional","affiliation":[{"name":"Department of Medicine Norton College of Medicine SUNY Upstate Medical University  Syracuse NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satish","family":"Krishnamurthy","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Norton College of Medicine SUNY Upstate Medical University  Syracuse NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,10,18]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0204926"},{"volume-title":"StatPearls [Internet]","year":"2023","author":"Koleva M","key":"e_1_2_10_3_1"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.13617"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2019.03.033"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10540\u2010005\u20102577\u20102"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3325\/cmj.2014.55.366"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2010.07.058"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000452169"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/2045\u20108118\u20109\u201013"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743\u20108454\u20106\u201016"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2017.10.013"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1517\/17425255.2016.1168804"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22073742"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics12010020"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clpt.2005.01.022"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/00498254.2017.1328148"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204\u2010021\u201003115\u2010y"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clpt.2006.02.004"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuros\/nyy303.123"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.3171\/2016.7.FOCUS16188"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.3171\/2017.10.JNS17439"}],"container-title":["The Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/accp1.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcph.2359","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T04:50:48Z","timestamp":1709009448000},"score":1,"resource":{"primary":{"URL":"https:\/\/accp1.onlinelibrary.wiley.com\/doi\/10.1002\/jcph.2359"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,18]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1002\/jcph.2359"],"URL":"https:\/\/doi.org\/10.1002\/jcph.2359","archive":["Portico"],"relation":{},"ISSN":["0091-2700","1552-4604"],"issn-type":[{"type":"print","value":"0091-2700"},{"type":"electronic","value":"1552-4604"}],"subject":[],"published":{"date-parts":[[2023,10,18]]},"assertion":[{"value":"2023-06-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}