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The purpose of the study was to evaluate the effect of <jats:italic>CYP2D6<\/jats:italic> polymorphism on the pharmacokinetics of dapoxetine in healthy Chinese men. Thirty\u2010nine subjects who received a single oral dose of 30\u00a0mg dapoxetine hydrochloride were classified based on their <jats:italic>CYP2D6<\/jats:italic> genotype: <jats:italic>*1\/*1<\/jats:italic> (n\u00a0=\u00a09), <jats:italic>*1\/*41<\/jats:italic> (n\u00a0=\u00a01), <jats:italic>*1\/*10<\/jats:italic> (n\u00a0=\u00a012), <jats:italic>*10\/*41<\/jats:italic> (n\u00a0=\u00a03), or <jats:italic>*10\/*10<\/jats:italic> (n\u00a0=\u00a014). The difference in pharmacokinetic parameters between different genotype groups was analyzed and then scored according to the activity score system. Compared with the wild\u2010type subjects of <jats:italic>CYP2D6 *1\/*1<\/jats:italic>, the peak plasma concentration (C<jats:sub>max<\/jats:sub>) and the area under the plasma drug concentration\u2010time curve (AUC<jats:sub>inf<\/jats:sub>) of dapoxetine in the <jats:italic>*10\/*10<\/jats:italic> and <jats:italic>*10\/*41<\/jats:italic> groups were notably increased (<jats:italic>P<\/jats:italic>\u00a0\u2264\u00a0.05). Significant differences in C<jats:sub>max<\/jats:sub>, AUC, volume of distribution\/bioavailability (V\/F) and clearance\/bioavailability (CL\/F) were observed among dapoxetine activity score groups (<jats:italic>P<\/jats:italic>\u00a0\u2264\u00a0.05). The AUC<jats:sub>inf<\/jats:sub> was increased significantly (154% and 89.73%, <jats:italic>P<\/jats:italic>\u00a0\u2264\u00a0.05) and the C<jats:sub>max<\/jats:sub> was increased significantly (73.45% and 42.67%, <jats:italic>P<\/jats:italic>\u00a0\u2264\u00a0.05) in <jats:italic>CYP2D6 *10\/*41<\/jats:italic> subjects, compared with <jats:italic>CYP2D6 *1\/*1<\/jats:italic> and <jats:italic>*1\/*10<\/jats:italic> subjects. The results obtained indicated that <jats:italic>CYP2D6 *10<\/jats:italic> and <jats:italic>*41<\/jats:italic> polymorphisms have significant effects on the pharmacokinetic properties of dapoxetine.<\/jats:p>","DOI":"10.1002\/jcph.2391","type":"journal-article","created":{"date-parts":[[2023,12,8]],"date-time":"2023-12-08T01:33:52Z","timestamp":1701999232000},"page":"601-608","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effects of <i>CYP2D6 *10 and *41<\/i> Variants in Healthy Chinese Men on the Pharmacokinetics of Dapoxetine"],"prefix":"10.1002","volume":"64","author":[{"given":"Zhipeng","family":"Wang","sequence":"first","affiliation":[{"name":"School of Pharmacy Lanzhou University  Lanzhou Gansu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Gao","sequence":"additional","affiliation":[{"name":"School of Pharmacy Lanzhou University  Lanzhou Gansu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xingfang","family":"Ji","sequence":"additional","affiliation":[{"name":"School of Pharmacy Lanzhou University  Lanzhou Gansu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tong","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Pharmacy Lanzhou University  Lanzhou Gansu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Libin","family":"Pu","sequence":"additional","affiliation":[{"name":"School of Pharmacy Lanzhou University  Lanzhou Gansu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen","family":"Qiu","sequence":"additional","affiliation":[{"name":"National Drug Clinical Trial Institution Lanzhou University Second Hospital  Lanzhou Gansu China"},{"name":"Pharmacy Department Lanzhou University Second Hospital  Lanzhou Gansu China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,1,4]]},"reference":[{"key":"e_1_2_11_2_1","volume-title":"Premature Ejaculation","author":"Crowdis M","year":"2023"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743\u20106109.2009.01362.x"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743\u20106109.2008.00825.x"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2006.10.025"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.esxm.2020.10.011"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/sexmed\/qfad034"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/YCO.0000000000000096"},{"key":"e_1_2_11_9_1","unstructured":"FDA.Dietary Supplement Ingredient Directory. 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