{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T05:38:40Z","timestamp":1757309920091,"version":"3.40.5"},"reference-count":59,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T00:00:00Z","timestamp":1714003200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["accp1.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Clinical Pharma"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Previous studies found that histamine H2 receptor antagonists (H2RAs) had blood pressure lowering and cardioprotective effects, but the impact of H2RAs on the survival outcomes of critically ill patients with essential hypertension is still unclear. The aim of this study was to investigate the association of H2RAs exposure with all\u2010cause mortality in patients with essential hypertension based on Medical Information Mart for Intensive Care III database. A total of 17,739 patients were included, involving 8482 H2RAs users and 9257 non\u2010H2RAs users. Propensity score matching (PSM) was performed to improve balance between 2 groups that were exposed to H2RAs or not. Kaplan\u2013Meier survival curves were used to compare the cumulative survival rates and multivariable Cox regression models were performed to evaluate the association between H2RAs exposure and all\u2010cause mortality. After 1:1 PSM, 4416 pairs of patients were enrolled. The results revealed potentially significant association between H2RAs exposure and decreased 30\u2010day, 90\u2010day, and 1\u2010year mortalities in multivariate analyses (HR = 0.783, 95% CI: 0.696\u20100.882 for 30\u2010day; HR = 0.860, 95% CI: 0.778\u20100.950 for 90\u2010day; and HR = 0.883, 95% CI: 0.811\u20100.961 for 1\u2010year mortality, respectively). Covariate effect analyses showed that the use of H2RAs was more beneficial in essential hypertension patients with age \u2265 60, BMI \u2265 25 kg\/m<jats:sup>2<\/jats:sup>, coronary arteriosclerosis, stroke, and acute kidney failure, respectively. In conclusion, H2RAs exposure was related to lower mortalities in critically ill patients with essential hypertension, which provided novel potential strategy for the use of H2RAs in essential hypertension patients.<\/jats:p>","DOI":"10.1002\/jcph.2445","type":"journal-article","created":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T07:09:06Z","timestamp":1714028946000},"page":"1112-1122","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Effect of Histamine H2 Receptor Antagonists on All\u2010Cause Mortality in Critically Ill Patients With Essential Hypertension: A Retrospective Cohort Study"],"prefix":"10.1002","volume":"64","author":[{"given":"Jian\u2010Mei","family":"Pan","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy 920th Hospital of Joint Logistics Support Force  Kunming China"},{"name":"College of Pharmacy Dali University  Dali 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