{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T10:10:40Z","timestamp":1790763040151,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T00:00:00Z","timestamp":1716854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["accp1.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Clinical Pharma"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Previous studies evaluating the risk of spontaneous abortions following exposure to macrolides reported controversial results. The goal of the current study was to examine the risk for spontaneous abortions following exposure to macrolides during pregnancy.<\/jats:p><jats:p>We conducted a population\u2010based retrospective cohort study by linking three computerized databases: Clalit Health Services drug dispensation database, Soroka Medical Center (SMC) birth database, and SMC hospitalizations database. Multivariate time\u2010varying Cox regressions were performed and adjusted for suspected confounders and known risk factors for spontaneous abortions. Hazard ratios (HR) and 95% confidence intervals (CI) were calculated. A secondary analysis was performed to assess the association between exposure to macrolides in terms of the defined daily dose dispensed and spontaneous abortions.<\/jats:p><jats:p>The study cohort included 65,457 pregnancies that ended at Soroka Medical Center between 2004 and 2009, of which 6508 (9.9%) resulted in a spontaneous abortion. A total of 825 (1.26%) pregnancies were exposed to macrolides during the exposure period. Exposure to macrolides was not associated with spontaneous abortions as a group (adjusted HR 1.00 95% CI 0.77\u20101.31) or as specific medications. There was no evidence of a dose\u2010response relationship between exposure to macrolides and spontaneous abortions.<\/jats:p><jats:p>In conclusion, this population\u2010based retrospective cohort study did not detect an increased risk for spontaneous abortion following exposure to macrolides during the first trimester of pregnancy.<\/jats:p>","DOI":"10.1002\/jcph.2458","type":"journal-article","created":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T13:39:09Z","timestamp":1716903549000},"page":"1288-1294","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Exposure to Macrolides During Pregnancy and the Risk for Spontaneous Abortions: A Population\u2010Based Retrospective Cohort Study"],"prefix":"10.1002","volume":"64","author":[{"given":"Shani","family":"Hegger","sequence":"first","affiliation":[{"name":"Department of Epidemiology, Biostatistics, and Community Health Sciences School of Public Health Faculty of Health Sciences, Ben\u2010Gurion University of the Negev  Beer\u2010Sheva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amalia","family":"Levy","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Biostatistics, and Community Health Sciences School of Public Health Faculty of Health Sciences, Ben\u2010Gurion University of the Negev  Beer\u2010Sheva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gideon","family":"Koren","sequence":"additional","affiliation":[{"name":"Ariel University  Ariel Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eitan","family":"Lunenfeld","sequence":"additional","affiliation":[{"name":"Ariel University  Ariel Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon","family":"Daniel","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Biostatistics, and Community Health Sciences School of Public Health Faculty of Health Sciences, Ben\u2010Gurion University of the Negev  Beer\u2010Sheva Israel"},{"name":"Department of Pediatrics Faculty of Health Sciences Ben\u2010Gurion University of the Negev  Beer\u2010Sheva Israel"},{"name":"Southern District Clalit Health Services  Beer\u2010Sheva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01691\u201012"},{"key":"e_1_2_9_3_1","volume-title":"Goodman & Gilman's The Pharmacological Basis of Therapeutics","author":"Brunton LL","year":"2011"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1086\/511159"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics5030029"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.1040766"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383\u2010016\u20103971\u20105"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405\u2010015\u20103872\u20106"},{"key":"e_1_2_9_9_1","unstructured":"KasperD FauciA HauserS LongoD JamesonJ LoscalzoJ.Chapter 192: Infections due to Campylobacter and related organisms. 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