{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T06:10:19Z","timestamp":1696399819509},"reference-count":40,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,2,14]],"date-time":"2014-02-14T00:00:00Z","timestamp":1392336000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Fundaci\u00ef\u00bf\u00bdn Canaria de Investigaci\u00ef\u00bf\u00bdn en Salud","award":["PI 16\/06"],"award-info":[{"award-number":["PI 16\/06"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Clinical Pharma"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label \/><jats:p>There is increasing controversy about the influence of serum paraoxonase type 1 and cytochrome CYP2C19 in the conversion of clopidogrel to its pharmaceutically active metabolite. The effect of concomitant medication with the proton pump inhibitor omeprazole has been also subject of intense scrutiny.<\/jats:p><jats:p>We present a cohort of 263 patients receiving anti\u2010platelet aggregation treatment with clopidogrel and aspirin for 1 year. The paraoxonase 1 gene Q192R variant along with the presence of CYP2C19*2 and *3 loss of function alleles, concomitant medication with proton pump inhibitors and known cardiovascular risk factors were examined to determine their influence in disease relapse due to an ischaemic event during the 12 month treatment period.<\/jats:p><jats:p>The low number of patients suffering a relapse (20 out of 263), indicates that double anti\u2010aggregation therapy with aspirin and clopidogrel was very effective in our patients. Among the relapsers, evidence of coronary heart disease was the most influencial factor affecting response to therapy, while the presence of the paraoxonase 1 Q192R variant, loss of function of CYP2C19, and concomitant medication with omeprazole were non\u2010significant.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcph.275","type":"journal-article","created":{"date-parts":[[2014,2,6]],"date-time":"2014-02-06T15:27:45Z","timestamp":1391700465000},"page":"843-849","source":"Crossref","is-referenced-by-count":6,"title":["Positive clinical response to clopidogrel is independent of paraoxonase 1 Q192R and CYP2C19 genetic variants"],"prefix":"10.1002","volume":"54","author":[{"given":"Efr\u00e9n","family":"Mart\u00ednez\u2010Quintana","sequence":"first","affiliation":[{"name":"Cardiology Department Complejo Hospitalario Universitario Insular Materno\u2010Infantil Las Palmas de Gran Canaria Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 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