{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T13:43:38Z","timestamp":1780407818037,"version":"3.54.1"},"reference-count":41,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,7,16]],"date-time":"2014-07-16T00:00:00Z","timestamp":1405468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Clinical Pharma"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Meropenem is frequently prescribed in children receiving continuous renal replacement therapy (CRRT). Fluid overload is often present in critically ill children and affects drug disposition. The purpose of this study was to develop a pharmacokinetic model to (1) evaluate target attainment of meropenem dosing regimens against <jats:italic>P. aeruginosa<\/jats:italic> in children receiving CRRT and (2) estimate the effect of fluid overload on target attainment. Clinical trial simulations were employed to evaluate target attainment of meropenem in various age groups and degrees of fluid overload in children receiving CRRT. Pharmacokinetic parameters were extracted from published literature, and 287 patients from the prospective pediatric CRRT registry database provided realistic clinical covariates including patient weight, fluid overload, and CRRT prescription characteristics. Target attainment at 40% and 75% time above the minimum inhibitory concentration was evaluated. Clinical trial simulations demonstrated that children greater than 5 years of age achieved acceptable target attainment with a dosing regimen of 20\u2009mg\/kg every 12\u2009hours. In children less than 5, however, increased dosing of 20\u2009mg\/kg every 8\u2009hours was needed to optimize target attainment. Fluid overload did not affect target attainment. These in silico model predictions will need to be verified in vivo in children receiving meropenem and CRRT.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcph.360","type":"journal-article","created":{"date-parts":[[2014,7,8]],"date-time":"2014-07-08T21:33:02Z","timestamp":1404855182000},"page":"1421-1428","source":"Crossref","is-referenced-by-count":25,"title":["Meropenem in children receiving continuous renal replacement therapy: Clinical trial simulations using realistic covariates"],"prefix":"10.1002","volume":"54","author":[{"given":"Edward J.","family":"Nehus","sequence":"first","affiliation":[{"name":"Division of Nephrology and Hypertension Cincinnati Children's Hospital Medical Center Cincinnati Ohio USA"},{"name":"Department of Pediatrics University of Cincinnati, College of Medicine Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samer","family":"Mouksassi","sequence":"additional","affiliation":[{"name":"Pharsight a Certara Company Montreal 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