{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T18:15:38Z","timestamp":1774376138515,"version":"3.50.1"},"reference-count":105,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":410,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Clinical Pharmacology"],"published-print":{"date-parts":[[2014,10]]},"DOI":"10.1002\/jcph.362","type":"journal-article","created":{"date-parts":[[2014,7,15]],"date-time":"2014-07-15T14:44:40Z","timestamp":1405435480000},"page":"1079-1092","source":"Crossref","is-referenced-by-count":78,"title":["The rationale of the myo-inositol and D-chiro-inositol combined treatment for polycystic ovary syndrome"],"prefix":"10.1002","volume":"54","author":[{"given":"Simona","family":"Dinicola","sequence":"first","affiliation":[{"name":"Dept of Experimental Medicine; Systems Biology Group; University La Sapienza; Roma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tony T. Y.","family":"Chiu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology; Faculty of Medicine; The Chinese University of Hong Kong; Shatin Hong Kong SAR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vittorio","family":"Unfer","sequence":"additional","affiliation":[{"name":"Lo.Li Pharma Medical Department; Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianfranco","family":"Carlomagno","sequence":"additional","affiliation":[{"name":"Lo.Li Pharma Medical Department; Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariano","family":"Bizzarri","sequence":"additional","affiliation":[{"name":"Dept of Experimental Medicine; Systems Biology Group; University La Sapienza; Roma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,7,18]]},"reference":[{"issue":"9","key":"10.1002\/jcph.362-BIB0001|jcph362-cit-0001","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1093\/ajcn\/33.9.1954","article-title":"Myo-inositol content of common foods: development of a high-myo-inositol diet","volume":"33","author":"Clements","year":"1980","journal-title":"Am J Clin Nutr"},{"issue":"1","key":"10.1002\/jcph.362-BIB0002|jcph362-cit-0002","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0009-8981(97)00161-7","article-title":"Glycosyl-phosphatidylinositol anchored membrane enzymes","volume":"266","author":"Hooper","year":"1997","journal-title":"Clin Chim Acta"},{"issue":"7112","key":"10.1002\/jcph.362-BIB0003|jcph362-cit-0003","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1038\/nature05185","article-title":"Phosphoinositides in cell regulation and membrane dynamics","volume":"443","author":"Di Paolo","year":"2006","journal-title":"Nature"},{"issue":"10","key":"10.1002\/jcph.362-BIB0004|jcph362-cit-0004","doi-asserted-by":"crossref","first-page":"2194","DOI":"10.1016\/S0021-9258(18)96606-8","article-title":"Biochemical studies on inositol. IX. D-Inositol 1-phosphate as intermediate in the biosynthesis of inositol from glucose 6-phosphate, and characteristics of two reactions in this biosynthesis","volume":"241","author":"Chen","year":"1966","journal-title":"J Biol Chem"},{"key":"10.1002\/jcph.362-BIB0005|jcph362-cit-0005","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1146\/annurev.bi.58.070189.003223","article-title":"Phospholipid biosynthesis in yeast","volume":"58","author":"Carman","year":"1989","journal-title":"Ann Rev Biochem"},{"issue":"6410","key":"10.1002\/jcph.362-BIB0006|jcph362-cit-0006","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/361315a0","article-title":"Inositol trisphosphate and calcium signalling","volume":"361","author":"Berridge","year":"1993","journal-title":"Nature"},{"issue":"2","key":"10.1002\/jcph.362-BIB0007|jcph362-cit-0007","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1210\/endo.132.2.8425485","article-title":"Chiroinositol deficiency and insulin resistance. III. Acute glycogenic and hypoglycemic effects of two inositol phosphoglycan insulin mediators in normal and streptozotocin-diabetic rats in vivo","volume":"132","author":"Huang","year":"1993","journal-title":"Endocrinology"},{"issue":"1","key":"10.1002\/jcph.362-BIB0008|jcph362-cit-0008","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1080\/15604280212528","article-title":"D-chiro-inositol-its functional role in insulin action and its deficit in insulin resistance","volume":"3","author":"Larner","year":"2002","journal-title":"Int J Exp Diabetes Res"},{"issue":"3","key":"10.1002\/jcph.362-BIB0009|jcph362-cit-0009","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1016\/S0006-291X(88)80520-5","article-title":"Rat liver insulin mediator which stimulates pyruvate dehydrogenase phosphate contains galactosamine and D-chiroinositol","volume":"151","author":"Larner","year":"1988","journal-title":"Biochem Biophys Res Commun"},{"issue":"4","key":"10.1002\/jcph.362-BIB0010|jcph362-cit-0010","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1073\/pnas.87.4.1476","article-title":"Anti-inositolglycan antibodies selectively block some of the actions of insulin in intact BC3H1 cells","volume":"87","author":"Romero","year":"1990","journal-title":"Proc Natl Acad Sci USA"},{"issue":"Pt 2","key":"10.1002\/jcph.362-BIB0011|jcph362-cit-0011","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1042\/bj2740369","article-title":"Transport in isolated rat hepatocytes of the phospho-oligosaccharide that mimics insulin action. Effects of adrenalectomy and glucocorticoid treatment","volume":"274","author":"Alvarez","year":"1991","journal-title":"Biochem J"},{"issue":"3","key":"10.1002\/jcph.362-BIB0012|jcph362-cit-0012","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1016\/S0006-291X(02)00313-3","article-title":"Both myo-inositol to chiro-inositol epimerase activities and chiro-inositol to myo-inositol ratios are decreased in tissues of GK type 2 diabetic rats compared to Wistar controls","volume":"293","author":"Sun","year":"2002","journal-title":"Biochem Biophys Res Commun"},{"issue":"2","key":"10.1002\/jcph.362-BIB0013|jcph362-cit-0013","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1042\/bst0170259","article-title":"The cellular functions of myo-inositol","volume":"17","author":"Downes","year":"1989","journal-title":"Biochem Soc Trans"},{"issue":"1","key":"10.1002\/jcph.362-BIB0014|jcph362-cit-0014","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1432-1033.1990.tb19297.x","article-title":"Myo-inositol metabolites as cellular signals","volume":"193","author":"Downes","year":"1990","journal-title":"Eur J Biochem"},{"issue":"Suppl 1","key":"10.1002\/jcph.362-BIB0015|jcph362-cit-0015","doi-asserted-by":"crossref","first-page":"S70","DOI":"10.1038\/sj.ejcn.1601820","article-title":"Micronutrient deficiencies in developing and affluent countries","volume":"57","author":"Diaz","year":"2003","journal-title":"Eur J Clin Nutr"},{"key":"10.1002\/jcph.362-BIB0016|jcph362-cit-0016","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/202599a0","article-title":"Reproductive tract as site of synthesis and secretion of inositol in the male rat","volume":"202","author":"Eisenberg","year":"1964","journal-title":"Nature"},{"issue":"2","key":"10.1002\/jcph.362-BIB0017|jcph362-cit-0017","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1530\/jrf.0.0420233","article-title":"Effect of dietary protein on the biosynthesis of inositol in rat testes","volume":"42","author":"Ghafoorunissa","year":"1975","journal-title":"J Reprod Fertil"},{"issue":"9","key":"10.1002\/jcph.362-BIB0018|jcph362-cit-0018","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/S0015-0282(16)39910-1","article-title":"Prostatic secretion as the source of myo-inositol in human seminal fluid","volume":"24","author":"Lewin","year":"1973","journal-title":"Fertil Steril"},{"issue":"2","key":"10.1002\/jcph.362-BIB0019|jcph362-cit-0019","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/0020-711X(82)90154-9","article-title":"Myo-inositol in the reproductive tract of the female rat","volume":"14","author":"Lewin","year":"1982","journal-title":"Int J Biochem"},{"issue":"6","key":"10.1002\/jcph.362-BIB0020|jcph362-cit-0020","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1007\/BF01204248","article-title":"A correlation of the outcome of clinical in vitro fertilization with the inositol content and embryotrophic properties of human serum","volume":"9","author":"Chiu","year":"1992","journal-title":"J Assist Reprod Genet"},{"issue":"8","key":"10.1002\/jcph.362-BIB0021|jcph362-cit-0021","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1080\/09513590903015544","article-title":"Efficacy of myo-inositol in the treatment of cutaneous disorders in young women with polycystic ovary syndrome","volume":"25","author":"Zacche","year":"2009","journal-title":"Gynecol Endocrinol"},{"issue":"4","key":"10.1002\/jcph.362-BIB0022|jcph362-cit-0022","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1095\/biolreprod.109.076760","article-title":"Involvement of phospholipase C-related inactive protein in the mouse reproductive system through the regulation of gonadotropin levels","volume":"81","author":"Matsuda","year":"2009","journal-title":"Biol Reprod"},{"issue":"5","key":"10.1002\/jcph.362-BIB0023|jcph362-cit-0023","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1093\/molehr\/5.5.441","article-title":"Presence and dynamic redistribution of type I inositol 1,4,5-trisphosphate receptors in human oocytes and embryos during in-vitro maturation, fertilization and early cleavage divisions","volume":"5","author":"Goud","year":"1999","journal-title":"Mol Hum Reprod"},{"issue":"1","key":"10.1002\/jcph.362-BIB0024|jcph362-cit-0024","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1095\/biolreprod.108.072538","article-title":"Maturation, fertilization, and the structure and function of the endoplasmic reticulum in cryopreserved mouse oocytes","volume":"81","author":"Lowther","year":"2009","journal-title":"Biol Reprod"},{"issue":"2","key":"10.1002\/jcph.362-BIB0025|jcph362-cit-0025","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1093\/humrep\/deg113","article-title":"Effects of myo-inositol on the in-vitro maturation and subsequent development of mouse oocytes","volume":"18","author":"Chiu","year":"2003","journal-title":"Hum Reprod"},{"issue":"2","key":"10.1002\/jcph.362-BIB0026|jcph362-cit-0026","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1530\/jrf.0.0960617","article-title":"Uptake and incorporation of inositol by preimplantation mouse embryos","volume":"96","author":"Kane","year":"1992","journal-title":"J Reprod Fertil"},{"issue":"4","key":"10.1002\/jcph.362-BIB0027|jcph362-cit-0027","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1002\/mrd.1080340407","article-title":"Incorporation of [3H]inositol into phosphoinositides and inositol phosphates by rabbit blastocysts","volume":"34","author":"Fahy","year":"1993","journal-title":"Mol Reprod Dev"},{"issue":"4","key":"10.1002\/jcph.362-BIB0028|jcph362-cit-0028","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/S0093-691X(99)00162-4","article-title":"High bovine blastocyst development in a static in vitro production system using SOFaa medium supplemented with sodium citrate and myo-inositol with or without serum-proteins","volume":"52","author":"Holm","year":"1999","journal-title":"Theriogenology"},{"key":"10.1002\/jcph.362-BIB0029|jcph362-cit-0029","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1146\/annurev.nu.06.070186.003023","article-title":"Metabolism and function of myo-inositol and inositol phospholipids","volume":"6","author":"Holub","year":"1986","journal-title":"Annu Rev Nutr"},{"issue":"4","key":"10.1002\/jcph.362-BIB0030|jcph362-cit-0030","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1007\/s10815-014-0188-1","article-title":"Improvement of mouse embryo quality by myo-inositol supplementation of IVF media","volume":"31","author":"Colazingari","year":"2014","journal-title":"J Assist Reprod Genet"},{"issue":"8","key":"10.1002\/jcph.362-BIB0031|jcph362-cit-0031","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.1242\/dev.122.8.2485","article-title":"Transient release of calcium from inositol 1,4,5-trisphosphate-specific stores regulates mouse preimplantation development","volume":"122","author":"Stachecki","year":"1996","journal-title":"Development"},{"issue":"8","key":"10.1002\/jcph.362-BIB0032|jcph362-cit-0032","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1006\/cbir.1994.1112","article-title":"Increase in cytoskeletal actin induced by inositol 1,4-bisphosphate in saponin-permeated pig platelets","volume":"18","author":"Huang","year":"1994","journal-title":"Cell Biol Int"},{"issue":"6","key":"10.1002\/jcph.362-BIB0033|jcph362-cit-0033","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1095\/biolreprod48.6.1251","article-title":"Regulation of the polyspermy block in the mouse egg: maturation-dependent differences in cortical granule exocytosis and zona pellucida modifications induced by inositol 1,4,5-trisphosphate and an activator of protein kinase C","volume":"48","author":"Ducibella","year":"1993","journal-title":"Biol Reprod"},{"issue":"3","key":"10.1002\/jcph.362-BIB0034|jcph362-cit-0034","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1677\/joe.1.06448","article-title":"Inositol triphosphate participates in an oestradiol nongenomic signalling pathway involved in accelerated oviductal transport in cycling rats","volume":"188","author":"Orihuela","year":"2006","journal-title":"J Endocrinol"},{"key":"10.1002\/jcph.362-BIB0035|jcph362-cit-0035","unstructured":"Carlomagno G Roseff S Harter S Murphy Cohen S Unfer V A novel approach for treating infertile patients with diminished ovarian reserve (DOR) 2011"},{"issue":"1-2","key":"10.1002\/jcph.362-BIB0036|jcph362-cit-0036","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.mce.2004.09.008","article-title":"Anti-Mullerian hormone and folliculogenesis","volume":"234","author":"Visser","year":"2005","journal-title":"Mol Cell Endocrinol"},{"issue":"1","key":"10.1002\/jcph.362-BIB0037|jcph362-cit-0037","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1530\/rep.1.00529","article-title":"Anti-Mullerian hormone: a new marker for ovarian function","volume":"131","author":"Visser","year":"2006","journal-title":"Reproduction"},{"issue":"1","key":"10.1002\/jcph.362-BIB0038|jcph362-cit-0038","first-page":"41","article-title":"Myo-Inositol homeostasis in the human fetus","volume":"62","author":"Quirk","year":"1983","journal-title":"Obstet Gynecol"},{"issue":"4","key":"10.1002\/jcph.362-BIB0039|jcph362-cit-0039","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/S0022-3476(87)80561-9","article-title":"Inositol supplementation in respiratory distress syndrome: relationship between serum concentration, renal excretion, and lung effluent phospholipids","volume":"110","author":"Hallman","year":"1987","journal-title":"J Pediatr"},{"issue":"1","key":"10.1002\/jcph.362-BIB0040|jcph362-cit-0040","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1038\/nm0197-60","article-title":"Inositol prevents folate-resistant neural tube defects in the mouse","volume":"3","author":"Greene","year":"1997","journal-title":"Nat Med"},{"issue":"6","key":"10.1002\/jcph.362-BIB0041|jcph362-cit-0041","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1097\/00001648-200111000-00009","article-title":"Effects of hyperinsulinemia and obesity on risk of neural tube defects among Mexican Americans","volume":"12","author":"Hendricks","year":"2001","journal-title":"Epidemiology"},{"issue":"3","key":"10.1002\/jcph.362-BIB0042|jcph362-cit-0042","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/S0002-9378(97)70543-X","article-title":"Dietary intake of myo-inositol and neural tube defects in offspring of diabetic rats","volume":"176","author":"Reece","year":"1997","journal-title":"Am J Obstet Gynecol"},{"issue":"8-9","key":"10.1002\/jcph.362-BIB0043|jcph362-cit-0043","first-page":"469","article-title":"Biochemical basis of the diabetic embryopathy","volume":"27","author":"Goldman","year":"1991","journal-title":"Isr J Med Sci"},{"issue":"2","key":"10.1002\/jcph.362-BIB0044|jcph362-cit-0044","doi-asserted-by":"crossref","first-page":"E5","DOI":"10.1136\/jmg.39.2.e5","article-title":"Inositol and folate resistant neural tube defects","volume":"39","author":"Cavalli","year":"2002","journal-title":"J Med Genet"},{"issue":"3","key":"10.1002\/jcph.362-BIB0045|jcph362-cit-0045","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1301\/00296640260042748","article-title":"Involvement of inositol in reproduction","volume":"60","author":"Beemster","year":"2002","journal-title":"Nutr Rev"},{"issue":"9","key":"10.1002\/jcph.362-BIB0046|jcph362-cit-0046","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.2337\/diab.38.9.1165","article-title":"Profound peripheral insulin resistance, independent of obesity, in polycystic ovary syndrome","volume":"38","author":"Dunaif","year":"1989","journal-title":"Diabetes"},{"issue":"1","key":"10.1002\/jcph.362-BIB0047|jcph362-cit-0047","doi-asserted-by":"crossref","first-page":"141","DOI":"10.2337\/diacare.22.1.141","article-title":"Prevalence of impaired glucose tolerance and diabetes in women with polycystic ovary syndrome","volume":"22","author":"Ehrmann","year":"1999","journal-title":"Diabetes Care"},{"issue":"8","key":"10.1002\/jcph.362-BIB0048|jcph362-cit-0048","first-page":"2694","article-title":"A fasting glucose to insulin ratio is a useful measure of insulin sensitivity in women with polycystic ovary syndrome","volume":"83","author":"Legro","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"10.1002\/jcph.362-BIB0049|jcph362-cit-0049","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1016\/S0015-0282(99)00401-X","article-title":"Alterations in low-density lipoprotein and high-density lipoprotein subclasses among Hispanic women with polycystic ovary syndrome: influence of insulin and genetic factors","volume":"72","author":"Legro","year":"1999","journal-title":"Fertil Steril"},{"issue":"13","key":"10.1002\/jcph.362-BIB0050|jcph362-cit-0050","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1056\/NEJM199509283331307","article-title":"Polycystic ovary syndrome","volume":"333","author":"Franks","year":"1995","journal-title":"N Engl J Med"},{"issue":"1","key":"10.1002\/jcph.362-BIB0051|jcph362-cit-0051","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1097\/gme.0b013e3181e8e1b1","article-title":"Effects of myo-inositol supplementation in postmenopausal women with metabolic syndrome: a perspective, randomized, placebo-controlled study","volume":"18","author":"Giordano","year":"2011","journal-title":"Menopause"},{"issue":"6","key":"10.1002\/jcph.362-BIB0052|jcph362-cit-0052","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1002\/j.1550-8528.1996.tb00271.x","article-title":"Dietary myoinositol results in lower urine glucose and in lower postprandial plasma glucose in obese insulin resistant rhesus monkeys","volume":"4","author":"Ortmeyer","year":"1996","journal-title":"Obes Res"},{"issue":"1","key":"10.1002\/jcph.362-BIB0053|jcph362-cit-0053","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1084\/jem.177.1.145","article-title":"Signal transduction in host cells by a glycosylphosphatidylinositol toxin of malaria parasites","volume":"177","author":"Schofield","year":"1993","journal-title":"J Exp Med"},{"issue":"2","key":"10.1002\/jcph.362-BIB0054|jcph362-cit-0054","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1210\/endo.132.2.8425483","article-title":"Chiroinositol deficiency and insulin resistance. I. Urinary excretion rate of chiroinositol is directly associated with insulin resistance in spontaneously diabetic rhesus monkeys","volume":"132","author":"Ortmeyer","year":"1993","journal-title":"Endocrinology"},{"issue":"13","key":"10.1002\/jcph.362-BIB0055|jcph362-cit-0055","doi-asserted-by":"crossref","first-page":"5924","DOI":"10.1073\/pnas.90.13.5924","article-title":"Chiro-inositol deficiency and insulin resistance: a comparison of the chiro-inositol- and the myo-inositol-containing insulin mediators isolated from urine, hemodialysate, and muscle of control and type II diabetic subjects","volume":"90","author":"Asplin","year":"1993","journal-title":"Proc Natl Acad Sci USA"},{"issue":"2","key":"10.1002\/jcph.362-BIB0056|jcph362-cit-0056","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1210\/endo.132.2.8425484","article-title":"Chiroinositol deficiency and insulin resistance. II. Acute effects of D-chiroinositol administration in streptozotocin-diabetic rats, normal rats given a glucose load, and spontaneously insulin-resistant rhesus monkeys","volume":"132","author":"Ortmeyer","year":"1993","journal-title":"Endocrinology"},{"issue":"2","key":"10.1002\/jcph.362-BIB0057|jcph362-cit-0057","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/S0889-8529(05)70078-5","article-title":"Insulin-lowering therapeutic modalities for polycystic ovary syndrome","volume":"28","author":"Ehrmann","year":"1999","journal-title":"Endocrinol Metab Clin North Am"},{"issue":"2","key":"10.1002\/jcph.362-BIB0058|jcph362-cit-0058","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S0015-0282(98)00454-3","article-title":"Effect of troglitazone on endocrine and ovulatory performance in women with insulin resistance-related polycystic ovary syndrome","volume":"71","author":"Hasegawa","year":"1999","journal-title":"Fertil Steril"},{"issue":"26","key":"10.1002\/jcph.362-BIB0059|jcph362-cit-0059","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1056\/NEJM199806253382603","article-title":"Effects of metformin on spontaneous and clomiphene-induced ovulation in the polycystic ovary syndrome","volume":"338","author":"Nestler","year":"1998","journal-title":"N Engl J Med"},{"issue":"1","key":"10.1002\/jcph.362-BIB0060|jcph362-cit-0060","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1210\/jc.2003-030437","article-title":"Metformin therapy increases insulin-stimulated release of D-chiro-inositol-containing inositolphosphoglycan mediator in women with polycystic ovary syndrome","volume":"89","author":"Baillargeon","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"10.1002\/jcph.362-BIB0061|jcph362-cit-0061","doi-asserted-by":"crossref","first-page":"300","DOI":"10.2337\/diacare.29.02.06.dc05-1070","article-title":"Altered D-chiro-inositol urinary clearance in women with polycystic ovary syndrome","volume":"29","author":"Baillargeon","year":"2006","journal-title":"Diabetes Care"},{"issue":"17","key":"10.1002\/jcph.362-BIB0062|jcph362-cit-0062","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1056\/NEJM199904293401703","article-title":"Ovulatory and metabolic effects of D-chiro-inositol in the polycystic ovary syndrome","volume":"340","author":"Nestler","year":"1999","journal-title":"N Engl J Med"},{"issue":"6","key":"10.1002\/jcph.362-BIB0063|jcph362-cit-0063","doi-asserted-by":"crossref","first-page":"417","DOI":"10.4158\/EP.8.6.417","article-title":"Effects of d-chiro-inositol in lean women with the polycystic ovary syndrome","volume":"8","author":"Iuorno","year":"2002","journal-title":"Endocr Pract"},{"issue":"10","key":"10.1002\/jcph.362-BIB0064|jcph362-cit-0064","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1016\/j.metabol.2008.05.008","article-title":"Insulin-stimulated release of D-chiro-inositol-containing inositolphosphoglycan mediator correlates with insulin sensitivity in women with polycystic ovary syndrome","volume":"57","author":"Cheang","year":"2008","journal-title":"Metabolism"},{"issue":"1","key":"10.1002\/jcph.362-BIB0065|jcph362-cit-0065","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1757-2215-5-14","article-title":"Does ovary need D-chiro-inositol","volume":"5","author":"Isabella","year":"2012","journal-title":"J Ovarian Res"},{"issue":"5","key":"10.1002\/jcph.362-BIB0066|jcph362-cit-0066","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1016\/j.fertnstert.2011.08.020","article-title":"Does metformin affect the ovarian response to gonadotropins for in vitro fertilization treatment in patients with polycystic ovary syndrome and reduced ovarian reserve? A randomized controlled trial","volume":"96","author":"Palomba","journal-title":"Fertil Steril"},{"issue":"24","key":"10.1002\/jcph.362-BIB0067|jcph362-cit-0067","doi-asserted-by":"crossref","first-page":"16904","DOI":"10.1016\/S0021-9258(18)41870-4","article-title":"In vivo conversion of [3H]myoinositol to [3H]chiroinositol in rat tissues","volume":"267","author":"Pak","year":"1992","journal-title":"J Biol Chem"},{"key":"10.1002\/jcph.362-BIB0068|jcph362-cit-0068","first-page":"i226","article-title":"NMR-based metabolomics reveals differently expressed metabolites in follicular fluid of pcos women: potential biomarkers for good quality oocyte?","volume":"26","author":"Chaudhary","year":"2011","journal-title":"Hum Reprod"},{"issue":"5","key":"10.1002\/jcph.362-BIB0069|jcph362-cit-0069","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1002\/nbm.1488","article-title":"NMR metabolic profile of human follicular fluid","volume":"23","author":"Pinero-Sagredo","year":"2010","journal-title":"NMR Biomed"},{"issue":"4","key":"10.1002\/jcph.362-BIB0070|jcph362-cit-0070","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.mehy.2012.01.009","article-title":"Oocyte quality reflected by follicular fluid analysis in poly cystic ovary syndrome (PCOS): A hypothesis based on intermediates of energy metabolism","volume":"78","author":"Arya","year":"2012","journal-title":"Med Hypotheses"},{"issue":"8","key":"10.1002\/jcph.362-BIB0071|jcph362-cit-0071","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1093\/molehr\/gam036","article-title":"Proteomic analysis of human ovaries from normal and polycystic ovarian syndrome","volume":"13","author":"Ma","year":"2007","journal-title":"Mol Hum Reprod"},{"key":"10.1002\/jcph.362-BIB0072|jcph362-cit-0072","doi-asserted-by":"publisher","DOI":"10.1177\/1933719113518985","article-title":"Hyperinsulinemia alters myoinositol to D-chiroinositol ratio in the follicular fluid of patients with PCOS. Published on line 4 February","author":"Unfer","year":"2014","journal-title":"Reprod Sci"},{"issue":"4","key":"10.1002\/jcph.362-BIB0073|jcph362-cit-0073","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s00404-006-0171-x","article-title":"Polycystic ovary syndrome: etiology and pathogenesis","volume":"274","author":"Matalliotakis","year":"2006","journal-title":"Arch Gynecol Obstet"},{"issue":"8","key":"10.1002\/jcph.362-BIB0074|jcph362-cit-0074","doi-asserted-by":"crossref","first-page":"2515","DOI":"10.1016\/j.fertnstert.2011.05.027","article-title":"The D-chiro-inositol paradox in the ovary","volume":"95","author":"Carlomagno","year":"2011","journal-title":"Fertil Steril"},{"issue":"2","key":"10.1002\/jcph.362-BIB0075|jcph362-cit-0075","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1507\/endocrj.EJ13-0423","article-title":"Decreased myo-inositol to chiro-inositol (m\/c) ratios and increased m\/c epimerase activity in pcos theca cells demonstrate increased insulin sensitivity compared to controls","volume":"61","author":"Heimark","year":"2013","journal-title":"Endocr J"},{"issue":"6","key":"10.1002\/jcph.362-BIB0076|jcph362-cit-0076","first-page":"2001","article-title":"Insulin stimulates testosterone biosynthesis by human thecal cells from women with polycystic ovary syndrome by activating its own receptor and using inositolglycan mediators as the signal transduction system","volume":"83","author":"Nestler","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"10.1002\/jcph.362-BIB0077|jcph362-cit-0077","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1016\/j.fertnstert.2008.01.088","article-title":"Myo-inositol may improve oocyte quality in intracytoplasmic sperm injection cycles. A prospective, controlled, randomized trial","volume":"91","author":"Papaleo","year":"2009","journal-title":"Fertil Steril"},{"issue":"4","key":"10.1002\/jcph.362-BIB0078|jcph362-cit-0078","first-page":"452","article-title":"Myo-inositol rather than D-chiro-inositol is able to improve oocyte quality in intracytoplasmic sperm injection cycles. A prospective, controlled, randomized trial","volume":"15","author":"Unfer","year":"2011","journal-title":"Eur Rev Med Pharmacol Sci"},{"issue":"12","key":"10.1002\/jcph.362-BIB0079|jcph362-cit-0079","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1080\/09513590701672405","article-title":"Myo-inositol in patients with polycystic ovary syndrome: a novel method for ovulation induction","volume":"23","author":"Papaleo","year":"2007","journal-title":"Gynecol Endocrinol"},{"issue":"3","key":"10.1002\/jcph.362-BIB0080|jcph362-cit-0080","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1080\/09513590801893232","article-title":"Myo-inositol administration positively affects hyperinsulinemia and hormonal parameters in overweight patients with polycystic ovary syndrome","volume":"24","author":"Genazzani","year":"2008","journal-title":"Gynecol Endocrinol"},{"issue":"6","key":"10.1002\/jcph.362-BIB0081|jcph362-cit-0081","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1093\/humrep\/17.6.1591","article-title":"Follicular fluid and serum concentrations of myo-inositol in patients undergoing IVF: relationship with oocyte quality","volume":"17","author":"Chiu","year":"2002","journal-title":"Hum Reprod."},{"issue":"8","key":"10.1002\/jcph.362-BIB0082|jcph362-cit-0082","doi-asserted-by":"crossref","first-page":"2642","DOI":"10.1016\/j.fertnstert.2011.01.035","article-title":"The role of inositol supplementation in patients with polycystic ovary syndrome, with insulin resistance, undergoing the low-dose gonadotropin ovulation induction regimen","volume":"95","author":"Morgante","year":"2011","journal-title":"Fertil Steril"},{"issue":"6","key":"10.1002\/jcph.362-BIB0083|jcph362-cit-0083","first-page":"151","article-title":"Effects of inositol on ovarian function and metabolic factors in women with PCOS: a randomized double blind placebo-controlled trial","volume":"7","author":"Gerli","year":"2003","journal-title":"Eur Rev Med Pharmacol Sci"},{"issue":"11","key":"10.1002\/jcph.362-BIB0084|jcph362-cit-0084","doi-asserted-by":"publisher","first-page":"920","DOI":"10.3109\/09513590.2011.564685","article-title":"The effect of a combination therapy with myo-inositol and a combined oral contraceptive pill versus a combined oral contraceptive pill alone on metabolic, endocrine, and clinical parameters in polycystic ovary syndrome","volume":"27","author":"Minozzi","year":"2011","journal-title":"Gynecol Endocrinol"},{"issue":"4","key":"10.1002\/jcph.362-BIB0085|jcph362-cit-0085","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/S1472-6483(10)60248-9","article-title":"Treatment of hirsutism with myo-inositol: a prospective clinical study","volume":"17","author":"Minozzi","year":"2008","journal-title":"Reprod Biomed Online"},{"issue":"4","key":"10.1002\/jcph.362-BIB0086|jcph362-cit-0086","doi-asserted-by":"crossref","first-page":"275","DOI":"10.3109\/09513590903366996","article-title":"Insulin sensitiser agents alone and in co-treatment with r-FSH for ovulation induction in PCOS women","volume":"26","author":"Raffone","year":"2010","journal-title":"Gynecol Endocrinol"},{"issue":"5","key":"10.1002\/jcph.362-BIB0087|jcph362-cit-0087","first-page":"575","article-title":"The combined therapy with myo-inositol and D-chiro-inositol reduces the risk of metabolic disease in PCOS overweight patients compared to myo-inositol supplementation alone","volume":"16","author":"Nordio","year":"2012","journal-title":"Eur Rev Med Pharmacol Sci"},{"issue":"1","key":"10.1002\/jcph.362-BIB0088|jcph362-cit-0088","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1093\/oxfordjournals.humrep.a019031","volume":"11","author":"Homburg","year":"1996","journal-title":"Hum Reprod"},{"issue":"10","key":"10.1002\/jcph.362-BIB0089|jcph362-cit-0089","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.2337\/diab.41.10.1257","article-title":"Evidence for distinctive and intrinsic defects in insulin action in polycystic ovary syndrome","volume":"41","author":"Dunaif","year":"1992","journal-title":"Diabetes"},{"issue":"6","key":"10.1002\/jcph.362-BIB0090|jcph362-cit-0090","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1097\/00060793-200012000-00009","article-title":"Insulin resistance and the polycystic ovary syndrome: recent advances","volume":"7","author":"Nestler","year":"2000","journal-title":"Curr Opin Endocrinol"},{"issue":"12","key":"10.1002\/jcph.362-BIB0091|jcph362-cit-0091","doi-asserted-by":"crossref","first-page":"989","DOI":"10.7326\/0003-4819-132-12-200006200-00010","article-title":"The importance of diagnosing the polycystic ovary syndrome","volume":"132","author":"Lobo","year":"2000","journal-title":"Ann Intern Med"},{"issue":"1","key":"10.1002\/jcph.362-BIB0092|jcph362-cit-0092","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.fertnstert.2003.10.004","article-title":"2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome","volume":"81","author":"Revised","year":"2004","journal-title":"Fertil Steril"},{"issue":"1","key":"10.1002\/jcph.362-BIB0093|jcph362-cit-0093","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1093\/humrep\/deh098","article-title":"2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS)","volume":"19","author":"Revised","year":"2004","journal-title":"Hum Reprod"},{"issue":"2","key":"10.1002\/jcph.362-BIB0094|jcph362-cit-0094","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.psychres.2007.11.022","article-title":"The association of nocturnal serum melatonin levels with major depression in patients with acute multiple sclerosis","volume":"161","author":"Akpinar","year":"2008","journal-title":"Psychiatry Res"},{"issue":"Pt 1","key":"10.1002\/jcph.362-BIB0095|jcph362-cit-0095","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1258\/000456303321016213","article-title":"Kinetics of myo-inositol loading in women of reproductive age","volume":"40","author":"Groenen","year":"2003","journal-title":"Ann Clin Biochem"},{"key":"10.1002\/jcph.362-BIB0096|jcph362-cit-0096","first-page":"931","article-title":"Inositol safety: clinical evidences","volume":"15","author":"Carlomagno","year":"2011","journal-title":"Eur Rev Med Pharmacol Sci"},{"issue":"7","key":"10.1002\/jcph.362-BIB0097|jcph362-cit-0097","doi-asserted-by":"crossref","first-page":"509","DOI":"10.3109\/09513590.2011.650660","article-title":"Effects of myo-inositol in women with PCOS: a systematic review of randomized controlled trials","volume":"28","author":"Unfer","year":"2012","journal-title":"Gynecol Endocrinol"},{"issue":"2","key":"10.1002\/jcph.362-BIB0098|jcph362-cit-0098","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.ejogrb.2009.09.008","article-title":"Contribution of myo-inositol to reproduction","volume":"147","author":"Papaleo","year":"2009","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"6","key":"10.1002\/jcph.362-BIB0099|jcph362-cit-0099","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1016\/j.fertnstert.2007.05.055","article-title":"Less is more: increased gonadotropin use for ovarian stimulation adversely influences clinical pregnancy and live birth after in vitro fertilization","volume":"89","author":"Pal","year":"2008","journal-title":"Fertil Steril"},{"key":"10.1002\/jcph.362-BIB0100|jcph362-cit-0100","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/1477-7827-10-52","article-title":"Pretreatment with myo-inositol in non polycystic ovary syndrome patients undergoing multiple follicular stimulation for IVF: a pilot study","volume":"10","author":"Lisi","year":"2012","journal-title":"Reprod Biol Endocrinol"},{"issue":"6","key":"10.1002\/jcph.362-BIB0101|jcph362-cit-0101","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1007\/s00404-013-2855-3","article-title":"The combined therapy myo-inositol plus D-chiro-inositol, rather than D-chiro-inositol, is able to improve IVF outcomes: results from a randomized controlled trial","volume":"288","author":"Colazingari","year":"2013","journal-title":"Arch Gynecol Obstet"},{"key":"10.1002\/jcph.362-BIB0102|jcph362-cit-0102","unstructured":"Personal communication at international Consensus Conference held in Florence December 2013"},{"key":"10.1002\/jcph.362-BIB0103|jcph362-cit-0103","first-page":"105","article-title":"Metabolic and hormonal effects of myo-inositol in women with polycystic ovary syndrome: a double-blind trial","volume":"13","author":"Costantino","year":"2009","journal-title":"Eur Rev Med Pharmacol Sci"},{"issue":"12","key":"10.1002\/jcph.362-BIB0104|jcph362-cit-0104","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1080\/09513590701672405","article-title":"Myo-inositol in patients with polycystic ovary syndrome: a novel method for ovulation induction","volume":"23","author":"Papaleo","year":"2007","journal-title":"Gynecol Endocrinol"},{"issue":"5","key":"10.1002\/jcph.362-BIB0105|jcph362-cit-0105","first-page":"347","article-title":"Randomized, double blind placebo-controlled trial: effects of myo-inositol on ovarian function and metabolic factors in women with PCOS","volume":"11","author":"Gerli","year":"2007","journal-title":"Eur Rev Med Pharmacol Sci"}],"container-title":["The Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcph.362","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcph.362","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1002\/jcph.362\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,14]],"date-time":"2022-07-14T13:03:47Z","timestamp":1657803827000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcph.362"}},"subtitle":["The Journal of Clinical Pharmacology"],"short-title":[],"issued":{"date-parts":[[2014,7,18]]},"references-count":105,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2014,10]]}},"URL":"https:\/\/doi.org\/10.1002\/jcph.362","archive":["Portico"],"relation":{},"ISSN":["0091-2700"],"issn-type":[{"value":"0091-2700","type":"print"}],"subject":[],"published":{"date-parts":[[2014,7,18]]}}}