{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T07:11:13Z","timestamp":1696403473515},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Clinical Pharma"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label \/><jats:p>Recently oral melatonin has been proposed as an agent for premedication. In this study, we compared melatonin with clonidine, considering its anxiolytic properties as well as the influence of both agents on the pharmacokinetic, hypnotic, and hemodynamic effects of propofol during propofol\u2013remifentanil total intravenous anesthesia (TIVA). The dataset under analysis included 32 patients scheduled for a functional endoscopic sinus surgery. The population pharmacokinetic modeling was done with NONMEM. The PK of propofol was described with a two\u2010compartment disposition model, whereas the BIS and AAI were described with a sigmoidal E<jats:sub>max<\/jats:sub> model linked with the propofol concentration via the biophase compartment. The anxiolytic effect was assessed by means of the visual analog scale for anxiety (VAS\u2010A). The population PK\/PD model was successfully developed to describe the data. No significant differences in the PK\/PD of propofol were noted due to the premedication with clonidine and melatonin. Melatonin was less effective than clonidine in reducing patients' anxiety at the induction of anesthesia, whereas clonidine premedication was associated with greater decrease in heart rate and blood pressure. A decreased EC<jats:sub>50<\/jats:sub> (2.47 vs. 3.17\u2009mg\/L) and increased slope (2.71 vs. 1.30) of the sigmoidal E<jats:sub>max<\/jats:sub> relationship was observed for the AAI index, as compared with the BIS measurements.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcph.401","type":"journal-article","created":{"date-parts":[[2014,9,22]],"date-time":"2014-09-22T09:24:19Z","timestamp":1411377859000},"page":"307-316","source":"Crossref","is-referenced-by-count":3,"title":["Melatonin and clonidine premedication has similar impact on the pharmacokinetics and pharmacodynamics of propofol target controlled\u2010infusions"],"prefix":"10.1002","volume":"55","author":[{"given":"Agnieszka","family":"Bienert","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy and Biopharmacy Poznan University of Medical Sciences ul. Marii Magdaleny 14 61 \u2010 861 Poznan Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarzyna","family":"Wawrzyniak","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Therapy Collegium Medicum in Bydgoszcz Nicolaus Copernicus University in Torun ul. Marii Sk\u0142odowskiej \u2010 Curie 9 85\u2010094 Bydgoszcz Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pawe\u0142","family":"Wiczling","sequence":"additional","affiliation":[{"name":"Department of Biopharmaceutics and Pharmacodynamics Medical University of Gdansk ul. Hallera 107 80\u2010401 Gdansk Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krzysztof","family":"Przyby\u0142owski","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy and Biopharmacy Poznan University of Medical Sciences ul. Marii Magdaleny 14 61 \u2010 861 Poznan Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zenon J.","family":"Kokot","sequence":"additional","affiliation":[{"name":"Department of Inorganic and Analytical Chemistry Poznan University of Medical Sciences ul. Grunwaldzka 6 60 \u2010 780 Poznan Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Matysiak","sequence":"additional","affiliation":[{"name":"Department of Inorganic and Analytical Chemistry Poznan University of Medical Sciences ul. Grunwaldzka 6 60 \u2010 780 Poznan Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agnieszka","family":"Pachutko","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy and Biopharmacy Poznan University of Medical Sciences ul. 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