{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T00:51:35Z","timestamp":1720399895108},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,2,4]],"date-time":"2015-02-04T00:00:00Z","timestamp":1423008000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Clinical Pharma"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label \/><jats:p>The proton pump inhibitor, rabeprazole, has been studied in children for the treatment of gastroesophageal reflux disease (GERD). In adults, rabeprazole is indicated for <jats:italic>Helicobacter pylori<\/jats:italic> eradication in combination with amoxicillin and clarithromycin. Nonlinear mixed effects modeling was conducted to estimate pharmacokinetic (PK) parameters for rabeprazole and its thioether metabolite from 336 subjects, 35% of whom were children 1\u201311 years with GERD from phase I and III studies. A 2\u2010compartment disposition model with a transit absorption model provided the best fit for rabeprazole PK. The steady\u2010state area under the concentration\u2010time curves given several candidate doses were simulated to identify a dose per each body weight group that is comparable to a 20\u2009mg twice\u2010daily dose in adults, which is the recommended dose for treatment of <jats:italic>H. pylori<\/jats:italic> in adults. Simulations provided the following recommended twice\u2010daily weight\u2010based doses for children \u22651 year and &lt;16 years: 10\u2009mg for 6\u201310\u2009kg, 15\u2009mg for 10\u201330\u2009kg, and 20\u2009mg for \u226530\u2009kg.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcph.457","type":"journal-article","created":{"date-parts":[[2015,1,5]],"date-time":"2015-01-05T11:10:52Z","timestamp":1420456252000},"page":"592-600","source":"Crossref","is-referenced-by-count":5,"title":["<i>Helicobacter pylori<\/i> treatment in children: Defining a dose for rabeprazole as a part of a triple therapy regimen"],"prefix":"10.1002","volume":"55","author":[{"given":"Holly","family":"Kimko","sequence":"first","affiliation":[{"name":"Janssen Research &amp; Development, LLC Raritan NJ USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"An","family":"Thyssen","sequence":"additional","affiliation":[{"name":"Janssen Research &amp; Development Janssen Pharmaceutica NV Beerse Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diane R.","family":"Mould","sequence":"additional","affiliation":[{"name":"Projections Research Inc. 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