{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T22:52:08Z","timestamp":1781304728391,"version":"3.54.1"},"reference-count":39,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,6,25]],"date-time":"2015-06-25T00:00:00Z","timestamp":1435190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81172581"],"award-info":[{"award-number":["81172581"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81272962"],"award-info":[{"award-number":["81272962"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Clinical Pharma"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>In this randomized, controlled clinical trial to compare efficacy and safety, 41 patients with labial discoid lupus erythematosus (DLE) were randomized to 2 groups, either receiving tacrolimus 0.03% ointment (n\u2009=\u200922) or triamcinolone acetonide 0.1% cream (n\u2009=\u200919). Each patient was treated with 3, 2, and 1 daily doses in the first, second, and third weeks, respectively, for 1 course. After the 3 week treatment, patients with complete disappearance of erosion were followed up for 3 months. After the 3 week application, 20 participants in the tacrolimus group and 19 in the triamcinolone acetonide group completed the study. The rates of complete response were 70% and 89.5% in tacrolimus\u2010treated and triamcinolone acetonide\u2013treated patients, respectively, with no significant difference (<jats:italic>P<\/jats:italic>\u2009=\u2009.235). Reduction in erosion and erythema showed no significant difference between groups (<jats:italic>P<\/jats:italic>\u2009&gt;\u2009.05). Final reduction in reticulation areas and numeric rating scale scores were significantly greater in the tacrolimus group than in the triamcinolone acetonide group (<jats:italic>P<\/jats:italic>\u2009=\u2009.013; <jats:italic>P\u2009<\/jats:italic>=\u2009.048, respectively). Only 1 patient receiving tacrolimus presented with slight discomfort. There was no significant difference in 3 month recurrence rate between the groups (<jats:italic>P\u2009<\/jats:italic>&gt;\u2009.05). Topical tacrolimus is considered as effective as triamcinolone acetonide for the management of labial DLE.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcph.537","type":"journal-article","created":{"date-parts":[[2015,5,6]],"date-time":"2015-05-06T22:49:04Z","timestamp":1430952544000},"page":"1221-1228","source":"Crossref","is-referenced-by-count":28,"title":["Tacrolimus 0.03% ointment in labial discoid lupus erythematosus: A randomized, controlled clinical trial"],"prefix":"10.1002","volume":"55","author":[{"given":"Xiangjian","family":"Wang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral Diseases West China Hospital of Stomatology Sichuan University Chengdu Sichuan P. R. 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