{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T19:10:25Z","timestamp":1722885025995},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,9,14]],"date-time":"2015-09-14T00:00:00Z","timestamp":1442188800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"European Framework Program"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Clinical Pharma"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Recent experimental data suggest bumetanide as a possible therapeutic option in newborn infants with seizures after birth asphyxia. Because pharmacokinetic (PK) data are lacking in this population, who very often benefit from therapeutic cooling, which can modify the PK behavior of a drug, a PK study was conducted in term infants with seizures caused by hypoxic\u2010ischemic encephalopathy. Fourteen infants were included, 13 of them being cooled. Forty\u2010nine blood samples were available for the determination of the plasma concentration of bumetanide. Concentration\u2010time data were analyzed by the use of a population approach performed with Monolix Software. Bumetanide was found to follow a 2\u2010compartment model. The mean values were 0.063 L\/h for clearance, 0.28 and 0.44 L for the central and peripheral distribution volumes, respectively, and 0.59 L\/h for the distribution clearance. Birth body weight explained the interindividual variability of bumetanide clearance via an allometric model. No relationship was found between bumetanide exposure and its efficacy (reduction in seizure burden) or its toxicity (hearing loss). This study describes the first PK model of bumetanide in hypothermia\u2010treated infants with seizures.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcph.596","type":"journal-article","created":{"date-parts":[[2015,7,20]],"date-time":"2015-07-20T03:43:55Z","timestamp":1437363835000},"page":"284-290","source":"Crossref","is-referenced-by-count":13,"title":["Pilot evaluation of the population pharmacokinetics of bumetanide in term newborn infants with seizures"],"prefix":"10.1002","volume":"56","author":[{"given":"Vincent","family":"Jullien","sequence":"first","affiliation":[{"name":"INSERM U1129 \u201cInfantile Epilepsies and Brain Plasticity,\u201d Paris, France; Paris Descartes University; CEA, Gif sur Yvette France"},{"name":"Service de Pharmacologie, H\u00f4pital Europ\u00e9en Georges Pompidou Assistance Publique H\u00f4pitaux de Paris Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronit M.","family":"Pressler","sequence":"additional","affiliation":[{"name":"Neuroscience Unit (ICH) and Neonatal Unit (IWH) University College London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geraldine","family":"Boylan","sequence":"additional","affiliation":[{"name":"INFANT Research Centre &amp; Neonatal Intensive Care Unit University College Cork Cork Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mats","family":"Blennow","sequence":"additional","affiliation":[{"name":"Neonatology, Karolinska Institutet and University Hospital Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neil","family":"Marlow","sequence":"additional","affiliation":[{"name":"Neuroscience Unit (ICH) and Neonatal Unit (IWH) University College London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Chiron","sequence":"additional","affiliation":[{"name":"INSERM U1129 \u201cInfantile Epilepsies and Brain Plasticity,\u201d Paris, France; Paris Descartes University; CEA, Gif sur Yvette France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerard","family":"Pons","sequence":"additional","affiliation":[{"name":"INSERM U1129 \u201cInfantile Epilepsies and Brain Plasticity,\u201d Paris, France; Paris Descartes University; CEA, Gif sur Yvette France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"for the NEMO Consortium Neonatal Seizure Treatment With Medication Off\u2010Patent","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,9,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.12812"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004218.pub2"},{"key":"e_1_2_7_4_1","unstructured":"WHO Guidelines on Neonatal Seizures. 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