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Opioids act on opioid receptors to significantly reduce pain for many patients, but there are significant addiction risks and side effects. In addition, opioids may exacerbate pain sensitivity and affect nerve regeneration. Non\u2010steroidal anti\u2010inflammatory drugs or acetaminophen act on cyclooxygenase enzymes and are commonly used for nerve pain, with 34.7% of people using them for neuropathic pain. While effective for mild pain, they are often combined with opioids, gamma\u2010aminobutyric acid (GABA) analogs, lidocaine, or corticosteroids for more severe pain. Corticosteroids, mimicking adrenal hormones like cortisol, treat PNI\u2010related inflammation and pain. Their pharmacokinetics are complex, often requiring local injections in order to minimize systemic risks while effectively treating PNIs. Lidocaine, a common local anesthetic, blocks ion channels in the central nervous system (CNS) and peripheral nerves, providing strong analgesic and anti\u2010inflammatory effects. If used improperly, lidocaine can cause neuronal toxicity instead of anesthetic effect. GABA acts as an inhibitory neurotransmitter in the CNS and its drug analogs like pregabalin and gabapentin can alleviate neuropathic pain by binding to voltage\u2010gated Ca<jats:sup>2+<\/jats:sup> channels, inhibiting neurotransmitter release. These pain medications are commonly prescribed for PNIs despite a limited guidance on their effects on nerve regeneration. This review will discuss these drug's mechanisms of action, pharmacokinetics\/pharmacodynamics, and their clinical application to highlight their effect on the PNI recovery.<\/jats:p>","DOI":"10.1002\/jcph.6156","type":"journal-article","created":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T07:43:37Z","timestamp":1730706217000},"page":"411-423","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The Role of Pain Medications in Modulating Peripheral Nerve Injury Recovery"],"prefix":"10.1002","volume":"65","author":[{"given":"JuliAnne E.","family":"Allgood","sequence":"first","affiliation":[{"name":"Department of Neuroscience University of Wyoming  Laramie WY USA"},{"name":"Co\u2010first authorship  Ivins UT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Logan","family":"Whitney","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Physics Southern Utah University  Cedar City UT USA"},{"name":"Co\u2010first authorship  Ivins UT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Goodwin","sequence":"additional","affiliation":[{"name":"College of Osteopathic Medicine Rocky Vista University  Ivins UT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1838-1206","authenticated-orcid":false,"given":"Brian S. 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