{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:45:24Z","timestamp":1786977924739,"version":"build-2736575974"},"reference-count":44,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T00:00:00Z","timestamp":1736208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R34HL152047"],"award-info":[{"award-number":["R34HL152047"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["U24TR001597"],"award-info":[{"award-number":["U24TR001597"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["accp1.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Clinical Pharma"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Pediatric asthma exacerbations represent a significant cause of emergency department use and hospitalizations. Despite available treatment options, many children's exacerbations are refractory to standard therapies and require adjunct treatments. The Intravenous Magnesium: Prompt use for Asthma in Children Treated in the Emergency Department study investigated the pharmacology of intravenous magnesium sulfate (IVMg) in treating pediatric asthma exacerbations. Specifically, the objectives of the study included (1) externally validating a previously published population pharmacokinetic model and (2) linking serum magnesium concentrations with outcomes including asthma severity score (efficacy) and hypotension (safety). Data were obtained from 49 children prospectively treated with IVMg (placebo, 50 or 75 mg\/kg) after presenting to the pediatric emergency department with an acute asthma exacerbation. Reductions in Pediatric Respiratory Assessment Measure scores were associated with both total and ionized serum magnesium area under the concentration\u2013time curve (AUC\n                    <jats:sub>0\u20132 h<\/jats:sub>\n                    ). Despite frequent study\u2010specific blood pressure monitoring, hypotension was uncommon in IVMg\u2010treated participants (n = 2\/31), and no concentration dependence was observed. The findings signal that IVMg may be an efficacious and safe option for treating moderate\u2013severe pediatric acute asthma exacerbations in the ED. Importantly, this study is the first to suggest a serum exposure target (total serum magnesium AUC\n                    <jats:sub>0\u20102 h<\/jats:sub>\n                    &gt;63.1 mg h\/L) reflective of effective IVMg dosing in pediatric acute asthma. While further study in a larger clinical trial is needed to refine and validate this exposure target, these findings support the continued study of IVMg therapy as an adjunct therapeutic option in the setting of pediatric asthma exacerbations.\n                  <\/jats:p>","DOI":"10.1002\/jcph.6179","type":"journal-article","created":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T08:09:37Z","timestamp":1736237377000},"page":"665-674","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Pharmacokinetics and Pharmacodynamics of Intravenous Magnesium Sulfate in Pediatric Acute Asthma Exacerbations"],"prefix":"10.1002","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3629-7902","authenticated-orcid":false,"given":"Joseph E.","family":"Rower","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology University of Utah  Salt Lake City UT USA"},{"name":"Center for Human Toxicology University of Utah  Salt Lake City UT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Division of Emergency Medicine Department of Pediatrics University of Utah and Primary Children's Hospital  Salt Lake City UT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph J.","family":"Zorc","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Children's Hospital of Philadelphia and Perelman School of Medicine University of Pennsylvania  Philadelphia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bashar","family":"Shihabuddin","sequence":"additional","affiliation":[{"name":"Section of Emergency Medicine Department of Pediatrics Nationwide Children's Hospital  Columbus OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengtao","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Utah  Salt Lake City UT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley J.","family":"Barney","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Utah  Salt Lake City UT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaron","family":"Finkelstein","sequence":"additional","affiliation":[{"name":"Division of Emergency Medicine and Division of Clinical Pharmacology and Toxicology Hospital for Sick Children  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,7]]},"reference":[{"key":"e_1_2_12_2_1","unstructured":"Agency for Healthcare Research and Quality.Healthcare Cost and Utilization Project (HCUP). 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