{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T10:18:31Z","timestamp":1784801911042,"version":"3.55.0"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,2,22]],"date-time":"2013-02-22T00:00:00Z","timestamp":1361491200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Clinical Pharma"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>This meta\u2010analysis was performed to compare the risk of cardiac events and restenosis between triple antiplatelet therapy (TAT, addition of cilostazol to aspirin and clopidogrel) and conventional dual antiplatelet therapy (DAT, aspirin and clopidogrel) in drug\u2010eluting stents (DES) implantation patients. We performed PUBMED, MEDLINE, EMBASE, and Cochrane CENTRAL searches for randomized clinical trials of TAT versus DAT in patients after DES implantation. Five clinical trials were involved in the study. TAT was associated with a 36% reduction in major adverse cardiac events (MACE; odds ratio (OR)\u2009=\u20090.64; 95% confidence interval (CI)\u2009=\u20090.51\u20130.81, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.01), a 40% reduction (OR\u2009=\u20090.60, 95% CI\u2009=\u20090.44\u20130.80; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.01) in target vessel revascularization (TVR), a 44% reduction (OR\u2009=\u20090.56, 95% CI\u2009=\u20090.34\u20130.91; <jats:italic>P<\/jats:italic>\u2009=\u2009.02) in target lesion revascularization (TLR) and a 47%\/44% reduction in in\u2010segment\/in\u2010stent restenosis (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.01) and lower in\u2010segment\/in\u2010stent late loss (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.01). As regards to the safety assessment, there was no significant difference about the risk of stent thrombosis and bleeding between TAT and DAT group, while the risk of gastrointestinal trouble was significantly higher in TAT group (OR\u2009=\u20092.46, 95% CI\u2009=\u20091.25\u20134.86; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.01). Addition of cilostazol to DAT reduced the incidence of MACE, TVR, and TLR after DES implantation. TAT also reduced the risk of restenosis and late loss in patients after DES implantation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcph.64","type":"journal-article","created":{"date-parts":[[2013,2,22]],"date-time":"2013-02-22T16:44:45Z","timestamp":1361551485000},"page":"532-539","source":"Crossref","is-referenced-by-count":10,"title":["Addition of Cilostazol to Conventional Dual Antiplatelet Therapy Reduces the Risk of Cardiac Events and Restenosis After Drug\u2010Eluting Stent Implantation: A Meta\u2010Analysis"],"prefix":"10.1002","volume":"53","author":[{"given":"Zhangwei","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Cardiology Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University Shanghai 200032 P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juying","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Cardiology Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University Shanghai 200032 P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinghua","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Medicine East Hospital, Tongji University School of Medicine Shanghai 200120 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianying","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Cardiology Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University Shanghai 200032 P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junbo","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Cardiology Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University Shanghai 200032 P.R. 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