{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T02:24:09Z","timestamp":1791167049849,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,12,21]],"date-time":"2015-12-21T00:00:00Z","timestamp":1450656000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Department of Clinical Chemistry"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Clinical Pharma"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Data on paricalcitol lowering albuminuria and proteinuria already exist; however, it is unclear how paricalcitol withdrawal affects both. Forty\u2010two nondialysis chronic kidney disease (CKD) patients (29 men) aged 62.3 \u00b1 12 years completed the study. CKD patients with proteinuria and intact parathyroid hormone \u226565 pg\/mL received paricalcitol (1 \u03bcg\/day po) for 6 months. After paricalcitol withdrawal we followed them for 6 more months. Paricalcitol treatment significantly reduced urinary albumin\/creatinine ratio (UACR), 24\u2010hour albuminuria (24hA), and 24\u2010hour proteinuria (24hP). Six months after drug withdrawal UACR increased significantly, 24hA and 24hP did not change significantly. Serum creatinine and cystatin C significantly increased during treatment, and estimated glomerular filtration rate (eGFR) decreased. After drug withdrawal serum creatinine, cystatin C, and eGFR did not change significantly. In conclusion, 6\u2010month paricalcitol treatment (1 \u03bcg\/day) in nondialysis CKD patients significantly reduced albuminuria and proteinuria. Six months after paricalcitol withdrawal 24hA and 24hP did not change significantly. Kidney function decreased during paricalcitol treatment; after paricalcitol withdrawal it remained stable. The unaltered values of 24hA, 24hP, and kidney function after paricalcitol withdrawal could be a delayed effect of paricalcitol treatment.<\/jats:p>","DOI":"10.1002\/jcph.660","type":"journal-article","created":{"date-parts":[[2015,10,14]],"date-time":"2015-10-14T15:49:27Z","timestamp":1444837767000},"page":"761-768","source":"Crossref","is-referenced-by-count":3,"title":["Proteinuria and Albuminuria During and After Paricalcitol Treatment in Chronic Kidney Disease Patients"],"prefix":"10.1002","volume":"56","author":[{"given":"Robert","family":"Ekart","sequence":"first","affiliation":[{"name":"Department of Dialysis, Clinic for Internal Medicine University Clinical Centre Maribor  Maribor Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastjan","family":"Bevc","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Clinic for Internal Medicine University Clinical Centre Maribor  Maribor Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radovan","family":"Hojs","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Clinic for Internal Medicine University Clinical Centre Maribor  Maribor Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Hojs","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Clinic for Internal Medicine University Clinical Centre Maribor  Maribor Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,12,21]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"S1","article-title":"KDIGO clinical practice guideline for the diagnosis, evaluation, prevention, and treatment of Chronic Kidney Disease\u2010Mineral and Bone Disorder (CKD\u2010MBD)","volume":"76","author":"Kidney Disease: Improving Global Outcomes (KDIGO) CKD\u2010MBD Work Group","year":"2009","journal-title":"Kidney Int."},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa041031"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2010.483"},{"key":"e_1_2_7_5_1","first-page":"716","article-title":"Vitamin D and proteinuria: a critical review of molecular bases and clinical experience","volume":"33","author":"Perez\u2010Gomez MV","year":"2013","journal-title":"Nefrologia"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.1999.064"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.2000.8237"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.2002.33395"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MBP.0b013e3283262f58"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-199917120-00013"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.24.507"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1114248"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2005.00755.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.108.113159"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2009.04.036"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61032-X"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-6686.2011.00229.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2369-14-163"},{"key":"e_1_2_7_19_1","first-page":"218A","article-title":"Vitamin D analogue therapy, cardiovascular risk and kidney function in type 1 diabetic patients with diabetic nephropathy: a randomized trial","volume":"23","author":"Joergensen C","year":"2012","journal-title":"J Am Soc Nephrol"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2369-13-150"},{"key":"e_1_2_7_21_1","first-page":"709","article-title":"Oral paricalcitol as antiproteinuric agent in chronic kidney disease","volume":"33","author":"Lorenzo A","year":"2013","journal-title":"Nefrologia"},{"key":"e_1_2_7_22_1","first-page":"401","article-title":"Microalbuminuria, another use for paricalcitol? Our experience in advanced chronic kidney disease","volume":"32","author":"Blanco\u2010Garcia R","year":"2012","journal-title":"Nefrologia"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/1744-9987.12080"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-1241.2010.02597.x"},{"key":"e_1_2_7_25_1","first-page":"98","article-title":"Renal function during calcitriol therapy in chronic renal failure","volume":"33","author":"Bertoli M","year":"1990","journal-title":"Clin Nephrol"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1996.d01-904.x"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2011.207"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2007.04.015"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-013-9887-0"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-012-9595-1"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc11-1309"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejcn.2012.134"}],"container-title":["The Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcph.660","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/accp1.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcph.660","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T07:53:32Z","timestamp":1696406012000},"score":1,"resource":{"primary":{"URL":"https:\/\/accp1.onlinelibrary.wiley.com\/doi\/10.1002\/jcph.660"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,21]]},"references-count":31,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["10.1002\/jcph.660"],"URL":"https:\/\/doi.org\/10.1002\/jcph.660","archive":["Portico"],"relation":{},"ISSN":["0091-2700","1552-4604"],"issn-type":[{"value":"0091-2700","type":"print"},{"value":"1552-4604","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,21]]}}}