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Based on the selected features, five models\u2014Logistic Regression, XGBoost, Random Forest, Naive Bayes, and Support Vector Machine\u2014were established. Finally, the model results were interpreted using SHAP. In this retrospective study, 187 patients were enrolled, and the incidence of LIT was 35.8%. An XGBoost model was established with good performance, in which the AUCs of the training set and validation set were all 0.9. The duration of linezolid treatment, ICU admission time, low baseline platelet level, shock, and concomitant use of piperacillin\u2010tazobactam were significant risk factors for LIT. A moderately raised level of platelet\u2010large cell ratio, total bilirubin, and weight may help reduce the incidence of LIT.<\/jats:p>","DOI":"10.1002\/jcph.70054","type":"journal-article","created":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T08:59:22Z","timestamp":1751619562000},"page":"1451-1459","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Development of a Risk Prediction Model for Linezolid\u2010Induced Thrombocytopenia Based on the Machine Learning Algorithm"],"prefix":"10.1002","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-3052-1299","authenticated-orcid":false,"given":"Jie","family":"Chi","sequence":"first","affiliation":[{"name":"Department of Pharmacy Tongling Municipal Hospital  Tongling Anhui People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Tongling Municipal Hospital  Tongling Anhui People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heng","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Tongling Municipal Hospital  Tongling Anhui People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengfu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Tongling Municipal Hospital  Tongling Anhui People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhifeng","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Tongling Municipal Hospital  Tongling Anhui People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,4]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkw450"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200161040-00008"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.3c01040"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.4046\/trd.2021.0122"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/17512433.2023.2181160"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-023-03542-z"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11096-021-01342-y"},{"issue":"3","key":"e_1_2_10_9_1","first-page":"415","article-title":"Use of Japanese big data from electronic medical records to investigate risk factors and identify their high\u2010risk combinations for linezolid\u2010induced thrombocytopenia","volume":"79","author":"Inoue Y","year":"2023","journal-title":"Eur J Clin Pharmacol"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkad191"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.001593"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmir.2019.09.005"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25225277"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dmpk.2024.101004"},{"key":"e_1_2_10_15_1","doi-asserted-by":"crossref","unstructured":"ChenT. 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