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This study aims to investigate the dosing regimen for pediatric patients aged 2 years and older. A physiologically based pharmacokinetic model for secukinumab was developed and validated in adult patients. Based on this model, two additional observation compartments for total interleukin\u201017A (IL\u201017A) and skin free IL\u201017A were incorporated to evaluate the inhibition of secukinumab on its targets. Ultimately, this model was extrapolated to pediatric patients. The model precisely captured the pharmacokinetic profiles and serum total IL\u201017A levels observed in different studies, encompassing various dosing schedules and formulations. Pediatric patients were stratified by weight, and the model incorporated age\u2010related developmental factors. 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