{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T03:28:04Z","timestamp":1789702084195,"version":"4.0.1"},"reference-count":36,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T00:00:00Z","timestamp":1750118400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["accp1.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Clinical Pharma"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This study aims to compare the efficacy and safety of different 5\u2010HT3 receptor antagonists as monotherapy for nausea and vomiting in patients undergoing surgery or chemotherapy. A thorough search of various electronic databases was conducted to determine the randomized controlled trials comparing the efficacy and safety of different 5\u2010HT3 receptor antagonists as monotherapy for preventing nausea and vomiting in patients undergoing surgery or chemotherapy. Primary outcomes included nausea, vomiting, and adverse events. A network meta\u2010analysis was performed to compare each outcome. Seventeen trials were included in this study. For the control of nausea, palonosetron was the optimal choice among 5\u2010HT3 receptor antagonists (surface under the cumulative ranking curve, SUCRA = 86.95%), regardless of whether the patients were undergoing surgery (SUCRA = 82.04%) or chemotherapy (SUCRA = 71.63%). As for controlling vomiting, palonosetron was still the optimal choice among different 5\u2010HT3 receptor antagonists (SUCRA = 80.87%). In surgical patients, granisetron was the most effective in controlling vomiting (SUCRA = 88.04%). When considering the drug doses, palonosetron 0.25 mg was the optimal regimen for controlling both nausea and vomiting. In terms of safety, palonosetron 0.25 mg and granisetron 3 mg were the safest regimens among different 5\u2010HT3 receptor antagonists. Among the various 5\u2010HT3 receptor antagonists, palonosetron at a dosage of 0.25 mg emerged as the optimal choice for chemotherapy patients, while granisetron at a dosage of 3 mg proved to be the best option for surgical patients, taking into account both efficacy and safety. The study protocol was registered with PROSPERO (CRD42024552117).<\/jats:p>","DOI":"10.1002\/jcph.70062","type":"journal-article","created":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T02:54:15Z","timestamp":1750215255000},"page":"1587-1597","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Efficacy and Safety of Different 5\u2010HT3 Receptor Antagonists as Monotherapy for Preventing Nausea and Vomiting in Patients Undergoing Surgery or Chemotherapy: A Network Meta\u2010Analysis of Randomized Controlled Trials"],"prefix":"10.1002","volume":"65","author":[{"given":"Hong","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Pharmacy Eye &amp; ENT Hospital\u00a0 Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuwen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Eye &amp; ENT Hospital\u00a0 Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiu","family":"Xin","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Eye &amp; ENT Hospital\u00a0 Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingchao","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Eye &amp; ENT Hospital\u00a0 Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taomin","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Eye &amp; ENT Hospital\u00a0 Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0000000000001485"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2015.01.024"},{"key":"e_1_2_9_4_1","first-page":"S259","article-title":"Overview of chemotherapy\u2010induced nausea and vomiting and evidence\u2010based therapies","volume":"23","author":"Adel N","year":"2017","journal-title":"Am J Manag Care"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2015.12.001"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-1-46"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctarc.2020.100278"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2011.02.003"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-015-0371-y"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2024.1414037"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000100"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.7326\/M14-2385"},{"key":"e_1_2_9_13_1","unstructured":"RoB 2: A revised Cochrane risk\u2010of\u2010bias tool for randomized trials. 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