{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T10:36:16Z","timestamp":1787567776350,"version":"build-2736575974"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T00:00:00Z","timestamp":1768176000000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["accp1.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Clinical Pharma"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Disparities in the performance of various kidney function equations in predicting aminoglycoside clearance (CL) have been identified. However, data specific to the Thai population remains limited. This study aimed to evaluate the performance of kidney function equations in estimating aminoglycoside CL in Thai patients. Data were retrospectively collected from hospitalized Thai patients who received amikacin or gentamicin over a 10\u2010year period. Population pharmacokinetic (PK) analysis was performed using a nonlinear mixed\u2010effects modeling approach. The association between aminoglycoside CL and kidney function, estimated by various equations, was ranked based on the magnitude of change in the Akaike Information Criterion (AIC) relative to the base model. A total of 138 adult Thai patients treated with either gentamicin (66%) or amikacin (34%) were enrolled. The non\u2010body surface area (BSA)\u2010indexed estimated glomerular filtration rate (eGFR) equations showed a stronger association with aminoglycoside CL compared to the 1.73 m\n                    <jats:sup>2<\/jats:sup>\n                    BSA\u2010indexed equations. The non\u2010BSA\u2010indexed 2021 Chronic Kidney Disease Epidemiology Collaboration eGFR (2021 CKD\u2010EPI eGFRcr) equation demonstrated the highest association with aminoglycoside CL. The estimated volume of distribution (V) and CL from the final model were 21.91\u00a0L and 2.62\u00a0L\/h, respectively. Among the Thai population, the non\u2010BSA\u2010indexed 2021 CKD\u2010EPI eGFRcr equation of the non\u2010race demonstrated the highest performance in estimating aminoglycoside CL. Further studies are warranted to confirm these findings with other renally eliminated drugs.\n                  <\/jats:p>","DOI":"10.1002\/jcph.70150","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T08:57:46Z","timestamp":1768208266000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Performance of Estimated Kidney Function Equations for Predicting Aminoglycosides Clearance in Thai Population"],"prefix":"10.1002","volume":"66","author":[{"given":"Sirima","family":"Sitaruno","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy Faculty of Pharmaceutical Sciences Prince of Songkla University  Songkhla Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Warunsuda","family":"Sripakdee","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy Faculty of Pharmaceutical Sciences Prince of Songkla University  Songkhla Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6511-4613","authenticated-orcid":false,"given":"Orawan","family":"Sae\u2010lim","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy Faculty of Pharmaceutical Sciences Prince of Songkla University  Songkhla Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dissaya","family":"Watthanapaisal","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy Faculty of Pharmaceutical Sciences Prince of Songkla University  Songkhla Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8992-3507","authenticated-orcid":false,"given":"Nuntapong","family":"Boonrit","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy Faculty of Pharmaceutical Sciences Prince of Songkla University  Songkhla Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kasemsiri","family":"Chandarajoti","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry Faculty of Pharmaceutical Sciences Prince of Songkla University  Songkhla Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3352-5060","authenticated-orcid":false,"given":"Rungsun","family":"Bhurayanontachai","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine Faculty of Medicine Prince of Songkla University  Songkhla Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sutthiporn","family":"Pattharachayakul","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy Faculty of Pharmaceutical Sciences Prince of Songkla University  Songkhla Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.2179"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajhp\/zxae317"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000180580"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.18773\/austprescr.2019.054"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2006.077180"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-150-9-200905050-00006"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2021.08.003"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2102953"},{"key":"e_1_2_10_10_1","unstructured":"Pharmacokinetics in Patients with Impaired Renal Function \u2014 Study Design Data Analysis and Impact on Dosing (Guidance for Industry). 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