{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T09:02:14Z","timestamp":1784538134880,"version":"3.55.0"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:00:00Z","timestamp":1780358400000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["accp1.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Clinical Pharma"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Expanded use of buprenorphine\u2013naloxone use, particularly for marginalized communities, such as the unhoused, is an established priority. Unfortunately, due to fear of the precipitation of opioid withdrawal, this goal remains unmet. In response, microdosing methods during the initial week of treatment do not require opioid abstinence and do not precipitate withdrawal. This review establishes the scientific basis for microdosing that is centered on the pharmacodynamic principle of pseudo\u2010irreversibility for a partial agonist, such as buprenorphine.<\/jats:p>","DOI":"10.1002\/jcph.70213","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T12:45:48Z","timestamp":1780404348000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Street Pharmacology: The Mechanistic Basis of Clinical Pharmacology Underlying the Microdosing Method of Buprenorphine\u2013Naloxone With a Focus on the Unhoused Population"],"prefix":"10.1002","volume":"66","author":[{"given":"David F","family":"Lehmann","sequence":"first","affiliation":[{"name":"Norton College of Medicine SUNY Upstate Medical University  Syracuse NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Tanner","sequence":"additional","affiliation":[{"name":"Norton College of Medicine SUNY Upstate Medical University  Syracuse NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliesha","family":"Pepple","sequence":"additional","affiliation":[{"name":"A Tiny Home for Good  Syracuse NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zarina Rashid","family":"Smith","sequence":"additional","affiliation":[{"name":"Help and Healing Outreach  Syracuse NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mia","family":"Ruiz\u2010Salvador","sequence":"additional","affiliation":[{"name":"Department of Medicine SUNY Upstate Medical University  Syracuse NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcph.6176"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11920-017-0783-9"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsat.2013.11.002"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp2210121"},{"key":"e_1_2_8_6_1","unstructured":"Suboxone[package insert]. 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