{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T09:51:49Z","timestamp":1791971509853,"version":"4.3.4"},"reference-count":45,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["accp1.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Clinical Pharma"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Aminoglycosides require therapeutic drug monitoring due to substantial pharmacokinetic variability across individuals. While population pharmacokinetic (popPK) models have been developed for individual drugs across age groups, and cross\u2010drug maturation models have been explored, it is unclear whether pooling data across aminoglycosides improves predictive performance. We developed and evaluated a unified multi\u2010aminoglycoside popPK model spanning neonates, children, and adults. De\u2010identified data from 5659 amikacin, gentamicin, and tobramycin patients at 154 US institutions were split into training and testing datasets. Predictive performance in the test dataset was evaluated using mean percent error, normalized root mean square error (nRMSE), and clinical accuracy (trough concentrations correctly classified as below or above 1 mg\/L and non\u2010troughs within 20% of observation), and compared with selected published popPK models. To assess generalizability, the final model was refit using single\u2010drug datasets and leave\u2010one\u2010subgroup\u2010out datasets. The unified model achieved the lowest nRMSE across age groups, with absolute reductions of 0.6%\u201024.8%. Clinical accuracy was highest for the unified model, with\n                    <jats:italic>a posteriori<\/jats:italic>\n                    accuracy in pediatric patients of 56.4% versus 48% in the best published model. Leave\u2010one\u2010out refits yielded similar estimates but reduced precision, while single\u2010drug models demonstrated substantially reduced precision, and one such model was not identifiable. This unified model improved predictive performance across drugs and age groups and demonstrated robustness to exclusion of individual drug\u2010age group combinations. These findings support use of a unified aminoglycoside model for Bayesian model\u2010informed precision dosing and demonstrate the advantages of pooling drugs within a class and across developmental stages.\n                  <\/jats:p>","DOI":"10.1002\/jcph.70231","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T07:01:59Z","timestamp":1788418919000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["One Model to Dose Them All: A Population Pharmacokinetic Model for Multiple Aminoglycosides Across the Human Lifespan"],"prefix":"10.1002","volume":"66","author":[{"given":"Dominic M. H.","family":"Tong","sequence":"first","affiliation":[{"name":"InsightRX  San Francisco CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan D.","family":"Faldasz","sequence":"additional","affiliation":[{"name":"InsightRX  San Francisco CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron J.","family":"Keizer","sequence":"additional","affiliation":[{"name":"InsightRX  San Francisco CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmine H.","family":"Hughes","sequence":"additional","affiliation":[{"name":"InsightRX  San Francisco CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,3]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/cb3005116"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciad428"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2010.337"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/124.Supplement_1.S145"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/124.Supplement_1.S148"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000244391"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228\u2010008\u20100599\u2010y"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a027029"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088\u2010200948040\u201000003"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088\u2010200948020\u201000001"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.2202"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/psp4.12353"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40262\u2010013\u20100036\u2010y"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00577\u201016"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14102089"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095\u2010014\u20101361\u2010z"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10928\u2010013\u20109348\u20107"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01304\u201016"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40262\u2010019\u201000762\u20104"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.13016"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofad500.2157"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201909\u20101874ST"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa241"},{"key":"e_1_2_11_25_1","unstructured":"World Health Organization.WHO consolidated guidelines on tuberculosis. 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