{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T13:20:06Z","timestamp":1787664006984,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["accp1.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Clinical Pharma"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Vancomycin therapeutic drug monitoring has moved toward area under the concentration\u2013time curve (AUC)\u2010guided dosing, but the clinical meaning of a Bayesian\u2010estimated AUC generated at an individual monitoring episode remains uncertain when renal clearance may already be changing. We conducted a retrospective multicenter cohort study using inpatient dosing, pharmacy, therapeutic drug monitoring, and laboratory data from two hospitals in Hai Phong, Viet Nam, between 2019 and 2025. The analysis included 898 adult index vancomycin monitoring episodes with valid Bayesian\u2010estimated AUC24 and sufficient serum creatinine data to ascertain acute kidney injury (AKI) within 48 h. AUC24 was estimated within the institutional Bayesian monitoring workflow using SmartDoseAI, with BestDose version 2.4.3 used as an independent pharmacokinetic cross\u2010check in selected clinically uncertain episodes. AKI occurred in 84 episodes (9.4%). Higher continuous AUC24 was associated with AKI in the minimally adjusted model (odds ratio, 1.16 per 100 mg\u00b7h\/L; 95% confidence interval, 1.02\u20131.33;\n                    <jats:italic>P<\/jats:italic>\n                    =\u00a0.023), whereas categorical AUC contrasts were imprecise. The association attenuated after exclusion of 23 episodes with possible pre\u2010existing AKI before the index monitoring episode (odds ratio, 1.12; 95% confidence interval, 0.96\u20131.31;\n                    <jats:italic>P<\/jats:italic>\n                    =\u00a0.159), and restricted cubic spline modeling did not identify a distinct nonlinear threshold. Bayesian\u2010estimated AUC24 at monitoring may therefore be most useful as a near\u2010term renal risk signal that integrates vancomycin exposure with evolving renal clearance, rather than as a standalone causal toxicity threshold.\n                  <\/jats:p>","DOI":"10.1002\/jcph.70265","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T14:55:00Z","timestamp":1786546500000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bayesian\u2010Estimated Vancomycin AUC24 as a Near\u2010Term Renal Risk Signal after Therapeutic Drug Monitoring: A Multicenter Cohort Study"],"prefix":"10.1002","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-6748-163X","authenticated-orcid":false,"given":"Tran","family":"Van Anh","sequence":"first","affiliation":[{"name":"Faculty of Pharmacy Hai Phong University of Medicine and Pharmacy  Hai Phong Viet Nam"},{"name":"Department of Pharmacy Hai Phong International Hospital  Hai Phong Viet Nam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3257-5215","authenticated-orcid":false,"given":"Bui Thi","family":"Tham","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Hai Phong University of Medicine and Pharmacy  Hai Phong Viet Nam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4514-713X","authenticated-orcid":false,"given":"Tran Thi","family":"Ngan","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Hai Phong University of Medicine and Pharmacy  Hai Phong Viet Nam"},{"name":"Department of Pharmacy Hai Phong International Hospital  Hai Phong Viet Nam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen Duc","family":"Long,","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Hai Phong International Hospital  Hai Phong Viet Nam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1576-6204","authenticated-orcid":false,"given":"Nguyen Huong","family":"Giang","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Hai Phong University of Medicine and Pharmacy  Hai Phong Viet Nam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen Hoang","family":"Anh","sequence":"additional","affiliation":[{"name":"Hanoi University of Pharmacy  Hanoi Viet Nam"},{"name":"Vietnam National Drug Information and Adverse Drug Reaction Monitoring Centre  Hanoi Viet Nam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7976-6716","authenticated-orcid":false,"given":"Vu Dinh","family":"Hoa","sequence":"additional","affiliation":[{"name":"Hanoi University of Pharmacy  Hanoi Viet Nam"},{"name":"Vietnam National Drug Information and Adverse Drug Reaction Monitoring Centre  Hanoi Viet Nam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoang","family":"Van Dung","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hai Phong International Hospital  Hai Phong Viet Nam"},{"name":"Department of Internal Medicine Hai Phong University of Medicine and Pharmacy  Hai Phong Viet Nam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0523-0852","authenticated-orcid":false,"given":"Nguyen Thi Thu","family":"Phuong","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Hai Phong University of Medicine and Pharmacy  Hai Phong Viet Nam"},{"name":"Department of Pharmacy Hai Phong International Hospital  Hai Phong Viet 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