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Volumetric microsampling enables self\u2010collection of small, fixed volume capillary samples for centralized analysis and may reduce hematocrit\u2010related volumetric bias associated with conventional dried blood spots. This scoping review, conducted according to the PRISMA Extension for Scoping Reviews, synthesized 67 patient\u2010cohort studies published from 2014 through 2026. Studies spanned at least 18 countries and multiple clinical specialties. Liquid chromatography\u2010tandem mass spectrometry was used in 61 studies (91%), and most reported validation using or referencing EMA, FDA, IATDMCT, or CLSI criteria. Recovery was minimally affected across evaluated hematocrit ranges for most analytes, and many analytes remained stable in dried samples, although stability varied by analyte and storage conditions. Where assessed, patient preference was high (80%\u2010100%). However, interpretation against established plasma therapeutic ranges often required whole\u2010blood\u2010to\u2010plasma or capillary\u2010to\u2010venous conversion, with inconsistent derivation and validation methods. Fixed conversion factors performed well for lacosamide and levetiracetam but were less reliable for lamotrigine at high concentrations. Several analyte\u2010matrix combinations, including cefepime, vancomycin, meropenem, paclitaxel, abiraterone, and mitotane, did not consistently meet agreement criteria. Volumetric microsampling can support patient\u2010centered drug monitoring when validated for the specific analyte, matrix, device, and clinical application. Future research should prioritize drug\u2010specific optimization, multicenter validation, standardized conversion reporting, and integration with MIPD platforms.<\/jats:p>","DOI":"10.1002\/jcph.70290","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T08:59:55Z","timestamp":1788512395000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Volumetric Microsampling for Patient\u2010Centric Therapeutic Drug Monitoring in Clinical Pharmacology: A Scoping Review"],"prefix":"10.1002","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-9493-3497","authenticated-orcid":false,"given":"Hari Prabhath","family":"Tummala","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy, College of Pharmacy University of Michigan  Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4310-4697","authenticated-orcid":false,"given":"Abbie D.","family":"Leino","sequence":"additional","affiliation":[{"name":"Division of Translational and Clinical Pharmacology Cincinnati Children's Hospital Medical Center  Cincinnati OH USA"},{"name":"Department of Pediatrics University of Cincinnati College of Medicine  Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0018-5434","authenticated-orcid":false,"given":"Nathaniel J.","family":"Rhodes","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Pharmacometrics Center of Excellence Midwestern University  Downers Grove IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5015-8146","authenticated-orcid":false,"given":"Kevin J.","family":"Downes","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Perelman School of Medicine at the University of Pennsylvania  Philadelphia PA USA"},{"name":"Division of Infectious Diseases Children's Hospital of Philadelphia  Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1091-6130","authenticated-orcid":false,"given":"Marc H.","family":"Scheetz","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Pharmacometrics Center of Excellence Midwestern University  Downers Grove IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7119-5034","authenticated-orcid":false,"given":"Manjunath P.","family":"Pai","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, College of Pharmacy University of Michigan  Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,4]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3904\/kjim.2009.24.1.1"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102125.2001.0520s1005.x"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0000000000001083"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines11071962"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2020.461731"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S278892"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac5022562"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2017.07.029"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph14070627"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.4155\/bio\u20102022\u20100202"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/17576180.2025.2477976"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26061787"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/1748\u20105908\u20105\u201069"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/1364557032000119616"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.7326\/M18\u20100850"},{"key":"e_1_2_11_17_1","doi-asserted-by":"crossref","unstructured":"TummalaHP.Volumetric microsampling for patient\u2010centric therapeutic drug monitoring in clinical pharmacology: a scoping review.2026. 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