{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T09:51:50Z","timestamp":1791971510102,"version":"4.3.4"},"reference-count":20,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["accp1.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Clinical Pharma"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The dose\u2010response profile of racemic ketamine in internalizing disorders is poorly characterized. This was a secondary analysis of outcome responses in patients with treatment\u2010resistant depression, post\u2010traumatic stress disorder, generalized and\/or social anxiety, or obsessive\u2010compulsive disorder. For each disorder, they received single intramuscular doses of racemic ketamine (0.5 and 1.0 mg\/kg) and a psychoactive control, using a three\u2010way within\u2010subject double\u2010blind active\u2010controlled cross\u2010over design. Intramuscular racemic ketamine doses of 0.5 and 1.0 mg\/kg produced robust effects on diagnosis\u2010appropriate outcome scales for all these internalizing disorders, compared with psychoactive controls. These effects were most obvious at 24\u00a0h after dosing and noticeably smaller at 168\u00a0h. The magnitude of change after 1 mg\/kg did not differ significantly from 0.5\u00a0mg\/kg at either time point, and did not differ significantly between the internalizing disorders at 24 h. When combined with other ketamine dose\u2010response data, we propose that ketamine may have a narrow inverted\u2010U dose\u2010response profile (peaking in the regions of 0.5\u20101.0 mg\/kg) in patients with internalizing disorders.<\/jats:p>","DOI":"10.1002\/jcph.70299","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T09:20:33Z","timestamp":1789550433000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ketamine Dose and Duration Effects in Internalizing Disorders"],"prefix":"10.1002","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4348-8221","authenticated-orcid":false,"given":"Neil","family":"McNaughton","sequence":"first","affiliation":[{"name":"Department of Psychology University of Otago  Dunedin New 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