{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:55:01Z","timestamp":1791287701541,"version":"4.3.0"},"reference-count":77,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["accp1.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Clinical Pharma"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Vaccination remains one of the most effective global health interventions, preventing substantial morbidity and mortality and advancing population health worldwide. However, vaccine hesitancy continues to limit vaccine confidence and uptake in some communities. This brief review summarizes the historical, social, and educational factors shaping vaccine hesitancy and outlines practical strategies to improve confidence and uptake. Key contributors include safety concerns amplified by misinformation, the rapid spread of misleading content through social media, and residual mistrust related to rare past research abuses and manufacturing failures. Additional barriers include socioeconomic disadvantage, limited scientific literacy, religious influences, clustering of vaccine\u2010resistant beliefs, health inequities, and distrust of healthcare institutions. This review emphasizes that effective responses must extend beyond simply providing more information. Evidence supports dialogue\u2010based, tailored communication, transparent discussion of risks and benefits, empathetic parent\u2013provider engagement, stronger vaccinology education for healthcare professionals, and improved access through combination vaccines, mobile clinics, and digital health tools. Addressing vaccine hesitancy requires coordinated, evidence\u2010based strategies centered on trust, communication, professional education, and equitable access to sustain public confidence in vaccination. As outlined in The American College of Clinical Pharmacology \u201cCall to Action,\u201d vaccine education is essential for safeguarding global health and trust in institutions involved in vaccine programs.<\/jats:p>","DOI":"10.1002\/jcph.70302","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:28:11Z","timestamp":1791286091000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Brief Review of Vaccine History, Hesitancy, and Education Today"],"prefix":"10.1002","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4413-066X","authenticated-orcid":false,"given":"Amir S.","family":"Youssef","sequence":"first","affiliation":[{"name":"GSK  Collegeville PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7323-296X","authenticated-orcid":false,"given":"Aman","family":"Gupta","sequence":"additional","affiliation":[{"name":"University of Detroit Mercy  Detroit MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0616-835X","authenticated-orcid":false,"given":"Sindura","family":"Gollamudi","sequence":"additional","affiliation":[{"name":"Eikon Therapeutics Inc.  Millbrae CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7505-102X","authenticated-orcid":false,"given":"Kenneth Todd","family":"Moore","sequence":"additional","affiliation":[{"name":"Johnson &amp; Johnson  New Brunswick NJ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,6]]},"reference":[{"key":"e_1_2_41_2_1","volume-title":"Immune system and disorders","author":"MedlinePlus"},{"key":"e_1_2_41_3_1","doi-asserted-by":"crossref","DOI":"10.1201\/9781315735368","volume-title":"Molecular Biology of the Cell","author":"Alberts B","year":"2017"},{"key":"e_1_2_41_4_1","volume-title":"How the Immune System Works","author":"Sompayrac LM","year":"2022"},{"key":"e_1_2_41_5_1","volume-title":"Increases in vaccine\u2010preventable disease outbreaks threaten years of progress, warn WHO, UNICEF, Gavi","author":"World Health Organization","year":"2025"},{"issue":"11","key":"e_1_2_41_6_1","doi-asserted-by":"crossref","DOI":"10.3389\/fpubh.2023.1326154","article-title":"Two centuries of vaccination: historical and conceptual approach and future perspectives","volume":"9","author":"Montero DA","year":"2024","journal-title":"Front Public Health"},{"key":"e_1_2_41_7_1","volume-title":"Pink Book: Epidemiology and Prevention of Vaccine\u2010Preventable Diseases","author":"Cen"},{"issue":"6","key":"e_1_2_41_8_1","first-page":"S163","article-title":"Global reduction of Hib disease: what are the next steps? 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