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Subjects established on daily methadone OST (mean dose 60 mg\/day) were switched to morphine slow\u2010release capsules, dosed at 4\u00d7 the previous total daily methadone dose, for 6 days, then given morphine syrup dosed q3h. All 27 subjects enrolled in this study completed the switch from methadone to morphine. Opioid withdrawal symptoms (OWS) peaked within 12\u201324 hours of starting morphine, and 24\/27 subjects required higher daily morphine doses (mean 5.2\u00d7 multiple). Pharmacokinetic evaluation showed that 91% of methadone was cleared during this time, with a mean elimination half\u2010life of 59 hours. The most frequent treatment\u2010emergent non\u2010OWS adverse events were headache, nausea, constipation, and neck pain. The method described here appears to be a safe and acceptable approach to switch subjects from methadone to morphine.<\/jats:p>","DOI":"10.1002\/jcph.704","type":"journal-article","created":{"date-parts":[[2016,1,14]],"date-time":"2016-01-14T03:28:58Z","timestamp":1452742138000},"page":"960-965","source":"Crossref","is-referenced-by-count":15,"title":["Switching Opioid\u2010Dependent Patients From Methadone to Morphine: Safety, Tolerability, and Methadone Pharmacokinetics"],"prefix":"10.1002","volume":"56","author":[{"given":"Paul","family":"Glue","sequence":"first","affiliation":[{"name":"University of Otago  Dunedin New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gavin","family":"Cape","sequence":"additional","affiliation":[{"name":"Southern District Health Board  Dunedin New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donna","family":"Tunnicliff","sequence":"additional","affiliation":[{"name":"Southern District Health Board  Dunedin New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Lockhart","sequence":"additional","affiliation":[{"name":"University of Auckland  Auckland New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fred","family":"Lam","sequence":"additional","affiliation":[{"name":"Zenith Technology  Dunedin New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Gray","sequence":"additional","affiliation":[{"name":"University of Otago  Dunedin New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noelyn","family":"Hung","sequence":"additional","affiliation":[{"name":"University of Otago  Dunedin New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. 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