{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T19:34:55Z","timestamp":1790969695294,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,10,6]],"date-time":"2016-10-06T00:00:00Z","timestamp":1475712000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Clinical Pharma"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Osteoporosis treatments reduce the risk of fractures by 30%\u201350%, but adherence after 1\u00a0year is only about 50%. Drug holiday, a period with no active treatment, is part of routine management. The objective of this study was to determine compliance and persistence with osteoporosis therapy among postmenopausal women and to assess attitudes regarding treatment resumption among patients on drug holiday. This was a prospective observational study of patients followed at a dedicated metabolic bone clinic September 2013\u2013February 2014. Compliance was assessed by medication possession ratio (MPR; number of doses dispensed relative to the number prescribed). Persistence was defined as continuation of treatment without a &gt;30\u2010day gap in prescription refills. Of 150 patients (70.1 \u00b1 8.1\u00a0years), 57% were prescribed a medication: 64% oral, mostly bisphosphonates. MPR \u2265 80% was found in 80% and &lt;50% in 12%; it was 100% for zoledronic acid and denosumab and 97%, 85%, 83%, and 70% for raloxifene, teriparatide, oral bisphosphonates, and strontium ranelate, respectively. Of 39 patients prescribed oral bisphosphonates, 77% persisted with treatment, and 89% took them as directed. Of 64 patients on a drug holiday, 59% expressed confidence in their physician's future treatment choice, whereas 19% expressed concerns about resuming treatment. Compliance among patients attending a dedicated bone clinic was higher than that reported in the literature. High persistence and compliance may be specific to patients followed in this type of setting. This study provides new information about attitudes of patients on a drug holiday. Most were not concerned about resuming treatment and did not have a preferred medication.<\/jats:p>","DOI":"10.1002\/jcph.738","type":"journal-article","created":{"date-parts":[[2016,3,22]],"date-time":"2016-03-22T02:28:46Z","timestamp":1458613726000},"page":"1416-1422","source":"Crossref","is-referenced-by-count":14,"title":["Compliance, Persistence, and Preferences Regarding Osteoporosis Treatment During Active Therapy or Drug Holiday"],"prefix":"10.1002","volume":"56","author":[{"given":"Alona","family":"Eliasaf","sequence":"first","affiliation":[{"name":"Division of Clinical Pharmacy, Pharmacy Services Meir Medical Center  Kfar Saba Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alina","family":"Amitai","sequence":"additional","affiliation":[{"name":"Division of Clinical Pharmacy, Pharmacy Services Meir Medical Center  Kfar Saba Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mira","family":"Maram Edry","sequence":"additional","affiliation":[{"name":"Hospital Administration Department Meir Medical Center  Kfar Saba Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shimona","family":"Yosselson Superstine","sequence":"additional","affiliation":[{"name":"Division of Clinical Pharmacy, School of Pharmacy The Hebrew University of Jerusalem  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pnina","family":"Rotman Pikielny","sequence":"additional","affiliation":[{"name":"Bone Health Service, Endocrine Department, Meir Medical Center, Kfar Saba, Israel, affiliated with the Sackler Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,10,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.4158\/EP.16.S3.1"},{"key":"e_1_2_9_3_1","first-page":"671","article-title":"Epidemiology of osteoporosis. 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