{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T23:34:09Z","timestamp":1786232049929,"version":"build-2736575974"},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,10,13]],"date-time":"2016-10-13T00:00:00Z","timestamp":1476316800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Clinical Pharma"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of this meta\u2010analysis was to evaluate the preventive efficacy and safety of 5\u2010HT<jats:sub>3<\/jats:sub>receptor antagonists (5\u2010HT<jats:sub>3<\/jats:sub>RAs) on perioperative shivering. Relevant databases were searched to identify eligible randomized, controlled trials through January 2016. Primary outcome was the incidence of perioperative shivering, and secondary outcomes were the incidence of safety\u2010related outcomes including postoperative nausea and vomiting (PONV), bradycardia, and hypotension. We calculated risk ratios (RRs) with 95% confidence intervals (CIs) for dichotomous data. Trial sequential analysis was performed to assess the risk of random errors and calculate the required information size. Sixteen studies with a total of 1126 patients were included in the meta\u2010analysis. Compared with the control group, 5\u2010HT<jats:sub>3<\/jats:sub>RAs administered intravenously could statistically significantly reduce the incidence of perioperative shivering (RR, 0.44; 95%CI, 0.35 to 0.56;<jats:italic>P<\/jats:italic>&lt; .00001; heterogeneity:<jats:italic>I<jats:sup>2<\/jats:sup><\/jats:italic>= 30%) as well as PONV (RR, 0.52; 95%CI, 0.28 to 0.97;<jats:italic>P<\/jats:italic>= .04; heterogeneity:<jats:italic>I<jats:sup>2<\/jats:sup><\/jats:italic>= 0%). However, they did not show superiority in lowering the rate of bradycardia (RR, 0.75; 95%CI, 0.38 to 1.49;<jats:italic>P<\/jats:italic>= 0.42; heterogeneity:<jats:italic>I<jats:sup>2<\/jats:sup><\/jats:italic>= 0%) or hypotension (RR, 0.79; 95%CI, 0.44 to 1.43;<jats:italic>P<\/jats:italic>= .44; heterogeneity:<jats:italic>I<jats:sup>2<\/jats:sup><\/jats:italic>= 24%). Trial sequential analysis of primary outcome showed that the required information size was 2634 patients and that the trial sequential monitoring boundary was crossed. Thus, more high\u2010quality randomized, controlled trials with larger sample sizes are still required to draw a definite conclusion about the preventive efficacy of 5\u2010HT<jats:sub>3<\/jats:sub>RAs on perioperative shivering prevention in the future.<\/jats:p>","DOI":"10.1002\/jcph.829","type":"journal-article","created":{"date-parts":[[2016,9,15]],"date-time":"2016-09-15T09:04:30Z","timestamp":1473930270000},"page":"428-439","source":"Crossref","is-referenced-by-count":9,"title":["5\u2010HT<sub>3<\/sub>Receptor Antagonists for the Prevention of Perioperative Shivering: A Meta\u2010Analysis"],"prefix":"10.1002","volume":"57","author":[{"given":"Wen","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Anesthesiology National Cancer Center\/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojing","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Emergency Peking University People's Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute for Hospital Management Tsinghua University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaobin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology National Cancer Center\/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology National Cancer Center\/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 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