{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T07:06:40Z","timestamp":1785654400973,"version":"3.56.0"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,5,6]],"date-time":"2013-05-06T00:00:00Z","timestamp":1367798400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Clinical Pharma"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>To prevent the participants of parabolic flights from nausea they are optionally treated with subcutaneously injected antiemetic scopolamine. The range of side effects of this substance include reductions of the \u03b1\u20102 frequency band. Previous studies, however, have given no information as to which generator centers are responsible for this effect. The objective of this study therefore, is to identify the cortex area that may be responsible for this effect. Six participants were subcutaneously administered 0.7\u2009mg of scopolamine. EEG was recorded for 10\u2009minutes before to 20\u2009minutes after injection. Data preprocessing followed including filtering and artifact minimization. A statistical analysis was performed with sLORETA\/eLORETA software for each subject over a time window from 3\u2009minutes before to 17\u201320\u2009minutes after scopolamine injection. Results show, that in the BA7, the precuneus, on both hemispheres suffered a \u03b1\u20102 activity decrease in absolute power. The identified brain cortex center is an important hub with high connectivity and centrality values within the neural network. It contributes to the control of movement and to space orientation. Therefore, an activity alteration in this area can possibly explain the antiemetic effect of scopolamine and open a window to understand the origin of motion sickness.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcph.83","type":"journal-article","created":{"date-parts":[[2013,5,6]],"date-time":"2013-05-06T16:08:46Z","timestamp":1367856526000},"page":"619-625","source":"Crossref","is-referenced-by-count":11,"title":["Localization of Scopolamine Induced Electrocortical Brain Activity Changes, in Healthy Humans at Rest"],"prefix":"10.1002","volume":"53","author":[{"given":"Pedro Miguel","family":"Ramos Reis","sequence":"first","affiliation":[{"name":"Friedrich\u2010Alexander\u2010Universit\u00e4t Erlangen\u2010N\u00fcrnberg Sport und Bewegungsmedizin \u2013 Institut f\u00fcr Sportwissenschaft und Sport Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger","family":"Eckhardt","sequence":"additional","affiliation":[{"name":"Friedrich\u2010Alexander\u2010Universit\u00e4t Erlangen\u2010N\u00fcrnberg Sport und Bewegungsmedizin \u2013 Institut f\u00fcr Sportwissenschaft und Sport Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Denise","sequence":"additional","affiliation":[{"name":"Normandie Univ UNICAEN, Inserm Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friedrich","family":"Bodem","sequence":"additional","affiliation":[{"name":"Friedrich\u2010Alexander\u2010Universit\u00e4t Erlangen\u2010N\u00fcrnberg Sport und Bewegungsmedizin \u2013 Institut f\u00fcr Sportwissenschaft und Sport Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Lochmann","sequence":"additional","affiliation":[{"name":"Friedrich\u2010Alexander\u2010Universit\u00e4t Erlangen\u2010N\u00fcrnberg Sport und Bewegungsmedizin \u2013 Institut f\u00fcr Sportwissenschaft und Sport Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,5,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2006.07.014"},{"issue":"4","key":"e_1_2_10_3_1","first-page":"1","article-title":"Scopolamine (hyoscine) for preventing and treating motion sickness (review)","author":"Spinks A","year":"2009","journal-title":"Cochrane Database Syst Rev."},{"key":"e_1_2_10_4_1","unstructured":"OmanCM.Motion sickness: a synthesis and evaluation of the sensory conflict theory.http:\/\/dx.doi.org\/10.1139\/y90\u20100441990."},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2044-8295.1992.tb02452.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1093\/oso\/9780195137255.003.0009","volume-title":"Space Physiology","author":"Buckey JC.","year":"2006"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(76)90286-0"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-1047(86)90772-7"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1552-4604.1998.tb04812.x"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2011.08.006"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000026588"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3908(87)90239-5"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2006.03.046"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00427761"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.351808"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/00912700122009836"},{"key":"e_1_2_10_17_1","unstructured":"JohannessonGH GudmundsdottiIR HelgasonJ et al. 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