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A systematic search was performed to retrieve English language studies using electronic search and manual checks of selected reference lists. Keywords included qualitative, cancer cachexia, weight loss, anorexia, appetite, malnutrition, food, eating, and drinking. The selection and appraisal of papers were undertaken by two reviewers. Twenty\u2010one qualitative articles were included in the review. There were three major findings emerging from the previous qualitative studies including \u2018the multidimensionality of weight loss and anorexia experience\u2019, \u2018patients and caregivers' responses to coping with weight loss and anorexia\u2019, and \u2018clinical assessment and management of weight loss and anorexia\u2019. The literature review revealed the multidimensional nature of cachexia and weight loss experience by patients and caregivers, which was not recognized and adequately managed by healthcare professionals. 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