{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T13:05:13Z","timestamp":1792242313894,"version":"4.4.0"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,3,31]],"date-time":"2015-03-31T00:00:00Z","timestamp":1427760000000},"content-version":"vor","delay-in-days":30,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Elevated resting energy expenditure (REE) may contribute to weight loss and symptom burden in cancer patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The aim of this study was to compare the velocity of weight loss, symptom burden (fatigue, insomnia, anxiety, and anorexia\u2014combined score as measured by the Edmonton Symptom Assessment Score), high\u2010sensitivity C\u2010reactive protein, and survival among cancer patients referred to a cachexia clinic with hypermetabolism, elevated REE\u2009&gt;\u2009110% of predicted, with normal REE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A retrospective analysis of 60 advanced cancer patients evaluated in a cachexia clinic for either &gt;5% weight loss or anorexia who underwent indirect calorimetry to measure REE. Patients were dichotomized to either elevated or normal REE. Descriptive statistics were generated, and a two\u2010sample Student's\n                      <jats:italic>t<\/jats:italic>\n                      \u2010tests were used to compare the outcomes between the groups. Kaplan\u2013Meier and Cox regression methodology were used to examine the survival times between groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Thirty\u2010seven patients (62%) were men, 41 (68%) were White, 59 (98%) solid tumours, predominantly 23 gastrointestinal cancers (38%), with a median age of 60 (95% confidence interval 57.0\u201362.9). Thirty\u2010five patients (58%) were hypermetabolic. Non\u2010Caucasian patients were more likely to have high REE [odds ratio\u2009=\u20096.17 (1.56, 24.8),\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.01]. No statistical difference regarding age, cancer type, gender, active treatment with chemotherapy, and\/or radiation between hypermetabolic and normal REE was noted. The velocity of weight loss over a 3\u2009month period (\u22128.5\u2009kg vs. \u22127.2\u2009kg,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.68), C\u2010reactive protein (37.3 vs. 55.6\u2009mg\/L,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.70), symptom burden (4.2 vs. 4.5,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.54), and survival (288 vs. 276\u2009days,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.68) was not significantly different between high vs. normal REE, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Hypermetabolism is common in cancer patients with weight loss and noted to be more frequent in non\u2010Caucasian patients. No association among velocity of weight loss, symptom burden, C\u2010reactive protein, and survival was noted in advanced cancer patients with elevated REE.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcsm.12014","type":"journal-article","created":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T02:52:15Z","timestamp":1427856735000},"page":"95-98","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["Hypermetabolism and symptom burden in advanced cancer patients evaluated in a cachexia clinic"],"prefix":"10.1002","volume":"6","author":[{"given":"Rony","family":"Dev","sequence":"first","affiliation":[{"name":"Department of Palliative Care and Rehabilitation Medicine The University of Texas MD Anderson Cancer Center  Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Hui","sequence":"additional","affiliation":[{"name":"Department of Palliative Care and Rehabilitation Medicine The University of Texas MD Anderson Cancer Center  Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Chisholm","sequence":"additional","affiliation":[{"name":"Department of Biostatisitics The University of Texas MD Anderson Cancer Center  Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marvin","family":"Delgado\u2010Guay","sequence":"additional","affiliation":[{"name":"Department of Palliative Care and Rehabilitation Medicine The University of Texas MD Anderson Cancer Center  Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shalini","family":"Dalal","sequence":"additional","affiliation":[{"name":"Department of Palliative Care and Rehabilitation Medicine The University of Texas MD Anderson Cancer Center  Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Egidio","family":"Del Fabbro","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology and Palliative Care, Massey Cancer Center Virginia Commonwealth University  Richmond VA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Bruera","sequence":"additional","affiliation":[{"name":"Department of Palliative Care and Rehabilitation Medicine The University of Texas MD Anderson Cancer Center  Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,3,31]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"76","volume-title":"Cachexia\u2010Anorexia in Cancer Patients","author":"Dunlop R","year":"1996"},{"key":"e_1_2_8_3_1","first-page":"79","article-title":"Costs and benefits of nutrition support in cancer","volume":"9","author":"Tchekmedyian NS","year":"1995","journal-title":"Oncology (Huntingt)"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0115426505020004369"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncponc0112"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0899-9007(97)00205-0"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1089\/jpm.2011.0098"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.1332"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2010.07.017"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70218-7"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.113.060228"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607190014002119"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2011-0151"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.12398"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1995.300"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1042\/cs0980389"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0026-0495(99)90074-4"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8223(98)00179-5"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14073-1"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejcn.1602114"}],"container-title":["Journal of Cachexia, Sarcopenia and Muscle"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcsm.12014","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcsm.12014","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T21:30:05Z","timestamp":1696541405000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcsm.12014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["10.1002\/jcsm.12014"],"URL":"https:\/\/doi.org\/10.1002\/jcsm.12014","archive":["Portico"],"relation":{},"ISSN":["2190-5991","2190-6009"],"issn-type":[{"value":"2190-5991","type":"print"},{"value":"2190-6009","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3]]},"assertion":[{"value":"2014-08-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-10-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-03-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}