{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T19:17:04Z","timestamp":1791314224648,"version":"4.3.1"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,4,21]],"date-time":"2015-04-21T00:00:00Z","timestamp":1429574400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Sumitomo Life Welfare and Culture Foundation"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Activity of xanthine oxidase is induced in cancer cachexia, and its inhibition by allopurinol or oxypurinol improves survival and reduces wasting in the Yoshida hepatoma cancer cachexia model. Here, we tested the effects of the second\u2010generation xanthine oxidase inhibitor febuxostat compared with placebo in the same model as used previously by our group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Wistar rats (~200\u2009g) were treated daily with febuxostat at 5\u2009mg\/kg\/day or placebo <jats:italic>via gavage<\/jats:italic> for <jats:italic>a maximum of<\/jats:italic> 17\u2009days. Weight change, quality of life, and body composition were analysed. After sacrifice, proteasome activity in the gastrocnemius muscle was measured. Muscle\u2010specific proteins involved in metabolism were analysed by western blotting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Treatment of the tumour\u2010bearing rats with febuxostat led to a significantly improved survival compared with placebo (hazard ratio: 0.45, 95% confidence interval: 0.22\u20130.93, <jats:italic>P<\/jats:italic>\u2009=\u20090.03). Loss of body weight was reduced (\u221226.3\u2009\u00b1\u200912.4\u2009g) compared with placebo (\u221250.2\u2009\u00b1\u20092.1\u2009g, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). Wasting of lean mass was attenuated (\u221212.7\u2009\u00b1\u200910.8\u2009g) vs. placebo (\u221231.9\u2009\u00b1\u20092.1\u2009g, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). While we did not see an effect of febuxostat on proteasome activity at the end of the study, the pAkt\/Akt ratio was improved by febuxostat (0.94\u2009\u00b1\u20090.09) vs. placebo (0.41\u2009\u00b1\u20090.05, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01), suggesting an increase in protein synthesis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Febuxostat attenuated cachexia progression and improved survival of tumour\u2010bearing rats.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcsm.12017","type":"journal-article","created":{"date-parts":[[2015,4,21]],"date-time":"2015-04-21T09:17:03Z","timestamp":1429607823000},"page":"174-180","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Febuxostat improves outcome in a rat model of cancer cachexia"],"prefix":"10.1002","volume":"6","author":[{"given":"Masaaki","family":"Konishi","sequence":"first","affiliation":[{"name":"Division of Innovative Clinical Trials University Medical Centre G\u00f6ttingen  G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loes","family":"Pelgrim","sequence":"additional","affiliation":[{"name":"Applied Cachexia Research, Center for Cardiovascular Research Charit\u00e9 Medical School  Berlin Germany"},{"name":"Radboud University Nijmegen  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anika","family":"Tschirner","sequence":"additional","affiliation":[{"name":"Applied Cachexia Research, Center for Cardiovascular Research Charit\u00e9 Medical School  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Baumgarten","sequence":"additional","affiliation":[{"name":"Applied Cachexia Research, Center for Cardiovascular Research Charit\u00e9 Medical School  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"von Haehling","sequence":"additional","affiliation":[{"name":"Division of Innovative Clinical Trials University Medical Centre G\u00f6ttingen  G\u00f6ttingen Germany"},{"name":"Department of Cardiology and Pneumology University Medical Centre G\u00f6ttingen  G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Palus","sequence":"additional","affiliation":[{"name":"Division of Innovative Clinical Trials University Medical Centre G\u00f6ttingen  G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfram","family":"Doehner","sequence":"additional","affiliation":[{"name":"Center for Stroke Research Berlin Charit\u00e9 Medical School  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan D.","family":"Anker","sequence":"additional","affiliation":[{"name":"Division of Innovative Clinical Trials University Medical Centre G\u00f6ttingen  G\u00f6ttingen 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