{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T21:54:45Z","timestamp":1794434085342,"version":"4.9.1"},"reference-count":52,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,4,30]],"date-time":"2015-04-30T00:00:00Z","timestamp":1430352000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002745","name":"Bayerische Forschungsstiftung","doi-asserted-by":"publisher","award":["FORMOsA"],"award-info":[{"award-number":["FORMOsA"]}],"id":[{"id":"10.13039\/501100002745","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Sarcopenia is linked to functional impairments, loss of independence, and mortality. In the past few years, obesity has been established as being a risk factor for a decline in muscle mass and function. There are several molecular pathological mechanisms, which have been under discussion that might explain this relationship. However, most studies were conducted using male animals and for a short period of time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this study, the gender\u2010specific effect of long\u2010term, high\u2010fat content feeding in Sprague\u2013Dawley rats was examined. Development of the quadriceps muscle of the animals was monitored <jats:italic>in vivo<\/jats:italic> using magnetic resonance. The results of these measurements and of the biochemical analysis of the aged muscle were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Surprisingly, only male but not female rats showed a decline in muscle cross\u2010sectional area at 16 months of age as a result of a chronic oversupply of dietary fats. This loss of muscle mass could not be explained by either de\u2010regulation of the anabolic Akt pathway or by up\u2010regulation of the main ubiquitin ligases of muscle, MAFbx and MuRF\u20101. However, fusion of satellite cells to myotubes was induced by the high\u2010fat diet in male rats, possibly as a result of an increased need for compensatory regeneration processes. Caspase\u20103\u2010dependent apoptosis induction, irrespective of diet, seems to be the major determinant of muscle decline during ageing in male but not female rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Taken together, activation of the apoptosis\u2010inducing Caspase\u20103 seems to be the most important trigger for the age\u2010related muscle loss. Male rats were more prone to the decline of muscle during ageing than female animals, which was further enforced by a long\u2010term, high fat diet.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcsm.12019","type":"journal-article","created":{"date-parts":[[2015,4,30]],"date-time":"2015-04-30T13:27:53Z","timestamp":1430400473000},"page":"181-191","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Gender\u2010specific differences in the development of sarcopenia in the rodent model of the ageing high\u2010fat rat"],"prefix":"10.1002","volume":"6","author":[{"given":"Robert","family":"Kob","sequence":"first","affiliation":[{"name":"Institute for Biomedicine of Aging, Friedrich\u2010Alexander\u2010Universit\u00e4t Erlangen\u2010N\u00fcrnberg  Nuremberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Fellner","sequence":"additional","affiliation":[{"name":"Institute of Radiology University Hospital Regensburg  Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Bertsch","sequence":"additional","affiliation":[{"name":"Institute of Clinical Chemistry, Laboratory Medicine and Transfusion Medicine Paracelsus Medical University  Nuremberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Astrid","family":"Wittmann","sequence":"additional","affiliation":[{"name":"Institute for Biomedicine of Aging, Friedrich\u2010Alexander\u2010Universit\u00e4t Erlangen\u2010N\u00fcrnberg  Nuremberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daria","family":"Mishura","sequence":"additional","affiliation":[{"name":"Institute for Biomedicine of Aging, Friedrich\u2010Alexander\u2010Universit\u00e4t Erlangen\u2010N\u00fcrnberg  Nuremberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornel C.","family":"Sieber","sequence":"additional","affiliation":[{"name":"Institute for Biomedicine of Aging, Friedrich\u2010Alexander\u2010Universit\u00e4t Erlangen\u2010N\u00fcrnberg  Nuremberg Germany"},{"name":"Department of General Internal Medicine and Geriatrics Hospital of the Order of St. John of God  Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara E.","family":"Fischer","sequence":"additional","affiliation":[{"name":"Institute for Biomedicine of Aging, Friedrich\u2010Alexander\u2010Universit\u00e4t Erlangen\u2010N\u00fcrnberg  Nuremberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Stroszczynski","sequence":"additional","affiliation":[{"name":"Institute of Radiology University Hospital Regensburg  Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelius L.","family":"Bollheimer","sequence":"additional","affiliation":[{"name":"Institute for Biomedicine of Aging, Friedrich\u2010Alexander\u2010Universit\u00e4t Erlangen\u2010N\u00fcrnberg  Nuremberg Germany"},{"name":"Department of General Internal Medicine and Geriatrics Hospital of the Order of St. John of God  Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,4,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afq034"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2014.03.007"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2000.tb06498.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2009.109"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10354-011-0910-x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"crossref","unstructured":"Cruz\u2010JentoftAJ LandiF SchneiderSM Z\u00fa\u00f1igaC AraiH BoirieY et al.Prevalence of and interventions for sarcopenia in ageing adults: a systematic review. 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