{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T23:56:10Z","timestamp":1791849370528,"version":"4.3.4"},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":127,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"name":"Grants-in-Aid for Scientific Research","award":["24390182"],"award-info":[{"award-number":["24390182"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Cachexia, Sarcopenia and Muscle"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1002\/jcsm.12028","type":"journal-article","created":{"date-parts":[[2015,4,27]],"date-time":"2015-04-27T10:20:17Z","timestamp":1430130017000},"page":"237-241","source":"Crossref","is-referenced-by-count":20,"title":["One-year intranasal application of growth hormone releasing peptide-2 improves body weight and hypoglycemia in a severely emaciated anorexia nervosa patient"],"prefix":"10.1002","volume":"6","author":[{"given":"Izumi","family":"Haruta","sequence":"first","affiliation":[{"name":"Department of Psychosomatic Internal Medicine, Graduate School of Medical and Dental Sciences; Kagoshima University and Kagoshima University Hospital; Kagoshima 890-8520 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Fuku","sequence":"additional","affiliation":[{"name":"Department of Psychosomatic Internal Medicine, Graduate School of Medical and Dental Sciences; Kagoshima University and Kagoshima University Hospital; Kagoshima 890-8520 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhisa","family":"Kinoshita","sequence":"additional","affiliation":[{"name":"Department of Psychosomatic Internal Medicine, Graduate School of Medical and Dental Sciences; Kagoshima University and Kagoshima University Hospital; Kagoshima 890-8520 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Yoneda","sequence":"additional","affiliation":[{"name":"Department of Psychosomatic Internal Medicine, Graduate School of Medical and Dental Sciences; Kagoshima University and Kagoshima University Hospital; Kagoshima 890-8520 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akinori","family":"Morinaga","sequence":"additional","affiliation":[{"name":"Department of Psychosomatic Internal Medicine, Graduate School of Medical and Dental Sciences; Kagoshima University and Kagoshima University Hospital; Kagoshima 890-8520 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Amitani","sequence":"additional","affiliation":[{"name":"Department of Psychosomatic Internal Medicine, Graduate School of Medical and Dental Sciences; Kagoshima University and Kagoshima University Hospital; Kagoshima 890-8520 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruka","family":"Amitani","sequence":"additional","affiliation":[{"name":"Department of Psychosomatic Internal Medicine, Graduate School of Medical and Dental Sciences; Kagoshima University and Kagoshima University Hospital; Kagoshima 890-8520 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Asakawa","sequence":"additional","affiliation":[{"name":"Department of Psychosomatic Internal Medicine, Graduate School of Medical and Dental Sciences; Kagoshima University and Kagoshima University Hospital; Kagoshima 890-8520 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Sugawara","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy and Pharmacology, Graduate School of Medical and Dental Sciences; Kagoshima University; Kagoshima 890-8520 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuo","family":"Takeda","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy and Pharmacology, Graduate School of Medical and Dental Sciences; Kagoshima University; Kagoshima 890-8520 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyril Y.","family":"Bowers","sequence":"additional","affiliation":[{"name":"Tulane University Health Sciences Center; New Orleans LA 70112 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akio","family":"Inui","sequence":"additional","affiliation":[{"name":"Department of Psychosomatic Internal Medicine, Graduate School of Medical and Dental Sciences; Kagoshima University and Kagoshima University Hospital; Kagoshima 890-8520 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,4,27]]},"reference":[{"key":"10.1002\/jcsm.12028-BIB0001|jcsm12028-cit-0001","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1016\/j.psychres.2013.07.042","article-title":"Mortality in eating disorders: a follow-up study of adult eating disorder patients treated in tertiary care, 1995-2010","volume":"210","author":"Suokas","year":"2013","journal-title":"Psychiatry Res"},{"key":"10.1002\/jcsm.12028-BIB0002|jcsm12028-cit-0002","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1016\/j.nut.2011.05.005","article-title":"Ghrelin and anorexia nervosa: a psychosomatic perspective","volume":"27","author":"Ogiso","year":"2011","journal-title":"Nutrition"},{"key":"10.1002\/jcsm.12028-BIB0003|jcsm12028-cit-0003","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1038\/sj.mp.4000944","article-title":"Eating behavior in anorexia nervosa - an excess of both orexigenic and anorexigenic signalling?","volume":"6","author":"Inui","year":"2001","journal-title":"Mol Psychiatry"},{"key":"10.1002\/jcsm.12028-BIB0004|jcsm12028-cit-0004","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/45230","article-title":"Ghrelin is a growth-hormone-releasing acylated peptide from stomach","volume":"402","author":"Kojima","year":"1999","journal-title":"Nature"},{"key":"10.1002\/jcsm.12028-BIB0005|jcsm12028-cit-0005","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1210\/endo-114-5-1537","article-title":"On the in vitro and in vivo activity of a new synthetic hexapeptide that acts on the pituitary to specifically release growth hormone","volume":"114","author":"Bowers","year":"1984","journal-title":"Endocrinology"},{"key":"10.1002\/jcsm.12028-BIB0006|jcsm12028-cit-0006","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/35086018","article-title":"Ghrelin: an orexigenic and somatotrophic signal from the stomach","volume":"2","author":"Inui","year":"2001","journal-title":"Nat Rev Neurosci"},{"key":"10.1002\/jcsm.12028-BIB0007|jcsm12028-cit-0007","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1124\/pr.109.001958","article-title":"Ghrelin gene products and the regulation of food intake and gut motility","volume":"61","author":"Chen","year":"2009","journal-title":"Pharmacol Rev"},{"key":"10.1002\/jcsm.12028-BIB0008|jcsm12028-cit-0008","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1210\/jc.2004-1719","article-title":"Growth hormone releasing peptide-2 (GHRP-2), like ghrelin, increases food intake in healthy men","volume":"90","author":"Laferrere","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1002\/jcsm.12028-BIB0009|jcsm12028-cit-0009","first-page":"4493","article-title":"Cancer anorexia-cachexia syndrome: are neuropeptides the key?","volume":"59","author":"Inui","year":"1999","journal-title":"Cancer Res"},{"key":"10.1002\/jcsm.12028-BIB0010|jcsm12028-cit-0010","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1007\/BF03327476","article-title":"Treatment of anorexia nervosa with TNF-alpha down-regulating agents","volume":"16","author":"Bou Khalil","year":"2011","journal-title":"Eat Weight Disord EWD"},{"key":"10.1002\/jcsm.12028-BIB0011|jcsm12028-cit-0011","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/j.jpsychires.2006.07.021","article-title":"Incomplete restoration of the secretion of ghrelin and PYY compared to insulin after food ingestion following weight gain in anorexia nervosa","volume":"41","author":"Nakahara","year":"2007","journal-title":"J Psychiatr Res"},{"key":"10.1002\/jcsm.12028-BIB0012|jcsm12028-cit-0012","doi-asserted-by":"crossref","first-page":"4800","DOI":"10.2174\/138161212803216870","article-title":"Clinical application of ghrelin","volume":"18","author":"Strasser","year":"2012","journal-title":"Curr Pharm Des"},{"key":"10.1002\/jcsm.12028-BIB0013|jcsm12028-cit-0013","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1210\/jc.2005-2304","article-title":"Ghrelin has partial or no effect on appetite, growth hormone, prolactin, and cortisol release in patients with anorexia nervosa","volume":"91","author":"Miljic","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1002\/jcsm.12028-BIB0014|jcsm12028-cit-0014","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1507\/endocrj.K09E-168","article-title":"Ghrelin increases hunger and food intake in patients with restricting-type anorexia nervosa: a pilot study","volume":"56","author":"Hotta","year":"2009","journal-title":"Endocr J"},{"key":"10.1002\/jcsm.12028-BIB0015|jcsm12028-cit-0015","doi-asserted-by":"crossref","first-page":"601","DOI":"10.7326\/0003-4819-149-9-200811040-00003","article-title":"Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults: a randomized trial","volume":"149","author":"Nass","year":"2008","journal-title":"Ann Intern Med"},{"key":"10.1002\/jcsm.12028-BIB0016|jcsm12028-cit-0016","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1210\/jc.2008-0632","article-title":"Effects of an oral growth hormone secretagogue in older adults","volume":"94","author":"White","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1002\/jcsm.12028-BIB0017|jcsm12028-cit-0017","doi-asserted-by":"crossref","first-page":"17942","DOI":"10.1074\/jbc.M112.358051","article-title":"Profound hypoglycemia in starved, ghrelin-deficient mice is caused by decreased gluconeogenesis and reversed by lactate or fatty acids","volume":"287","author":"Li","year":"2012","journal-title":"J Biol Chem"}],"container-title":["Journal of Cachexia, Sarcopenia and Muscle"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcsm.12028","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1002\/jcsm.12028\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,3]],"date-time":"2021-07-03T11:34:22Z","timestamp":1625312062000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcsm.12028"}},"subtitle":["GHRP-2 treatment for anorexia nervosa"],"short-title":[],"issued":{"date-parts":[[2015,4,27]]},"references-count":17,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,9]]}},"URL":"https:\/\/doi.org\/10.1002\/jcsm.12028","archive":["Portico"],"relation":{},"ISSN":["2190-5991"],"issn-type":[{"value":"2190-5991","type":"print"}],"subject":[],"published":{"date-parts":[[2015,4,27]]}}}