{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T18:23:40Z","timestamp":1793125420616,"version":"4.5.0"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":134,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"name":"Netherlands Organization for Scientific Research","award":["022.003.011"],"award-info":[{"award-number":["022.003.011"]}]},{"name":"Netherlands Organization for Scientific Research","award":["907-00-033"],"award-info":[{"award-number":["907-00-033"]}]},{"name":"Niels Stensen Stichting"},{"name":"Sir Stanley and Lady Davidson Endowment Fund","award":["E08473"],"award-info":[{"award-number":["E08473"]}]},{"DOI":"10.13039\/501100000589","name":"Chief Scientist Office","doi-asserted-by":"crossref","award":["CZG\/4\/1\/5"],"award-info":[{"award-number":["CZG\/4\/1\/5"]}],"id":[{"id":"10.13039\/501100000589","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Cachexia, Sarcopenia and Muscle"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1002\/jcsm.12029","type":"journal-article","created":{"date-parts":[[2015,4,20]],"date-time":"2015-04-20T09:44:14Z","timestamp":1429523054000},"page":"212-221","source":"Crossref","is-referenced-by-count":61,"title":["Effects of oral meal feeding on whole body protein breakdown and protein synthesis in cachectic pancreatic cancer patients"],"prefix":"10.1002","volume":"6","author":[{"given":"David P.J.","family":"van Dijk","sequence":"first","affiliation":[{"name":"Department of Surgery; Maastricht University Medical Centre; Maastricht The Netherlands"},{"name":"NUTRIM School of Nutrition and Translational Research in Metabolism; Maastricht University; Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel C.G.","family":"van de Poll","sequence":"additional","affiliation":[{"name":"Department of Surgery; Maastricht University Medical Centre; Maastricht The Netherlands"},{"name":"NUTRIM School of Nutrition and Translational Research in Metabolism; Maastricht University; Maastricht The Netherlands"},{"name":"Department of Intensive Care Medicine; Maastricht University Medical Centre; Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alastair G.W.","family":"Moses","sequence":"additional","affiliation":[{"name":"Department of Surgery; Royal Infirmary of Edinburgh; Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Preston","sequence":"additional","affiliation":[{"name":"Stable Isotope Biochemistry Laboratory; Scottish Universities Environmental Research Centre; East Kilbride Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven W.M.","family":"Olde Damink","sequence":"additional","affiliation":[{"name":"Department of Surgery; Maastricht University Medical Centre; Maastricht The Netherlands"},{"name":"NUTRIM School of Nutrition and Translational Research in Metabolism; Maastricht University; Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sander S.","family":"Rensen","sequence":"additional","affiliation":[{"name":"Department of Surgery; Maastricht University Medical Centre; Maastricht The Netherlands"},{"name":"NUTRIM School of Nutrition and Translational Research in Metabolism; Maastricht University; Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolaas E.P.","family":"Deutz","sequence":"additional","affiliation":[{"name":"Department of Surgery; Maastricht University Medical Centre; Maastricht The Netherlands"},{"name":"NUTRIM School of Nutrition and Translational Research in Metabolism; Maastricht University; Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter B.","family":"Soeters","sequence":"additional","affiliation":[{"name":"Department of Surgery; Maastricht University Medical Centre; Maastricht The Netherlands"},{"name":"NUTRIM School of Nutrition and Translational Research in Metabolism; Maastricht University; Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James A.","family":"Ross","sequence":"additional","affiliation":[{"name":"Department of Surgery; Royal Infirmary of Edinburgh; Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth C.H.","family":"Fearon","sequence":"additional","affiliation":[{"name":"Department of Surgery; Royal Infirmary of Edinburgh; Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelis H.C.","family":"Dejong","sequence":"additional","affiliation":[{"name":"Department of Surgery; Maastricht University Medical Centre; Maastricht The Netherlands"},{"name":"NUTRIM School of Nutrition and Translational Research in Metabolism; Maastricht University; Maastricht The Netherlands"},{"name":"Department of Surgery; Royal Infirmary of Edinburgh; Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,4,20]]},"reference":[{"key":"10.1002\/jcsm.12029-BIB0001|jcsm12029-cit-0001","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3322\/caac.20107","article-title":"Global cancer statistics","volume":"61","author":"Jemal","year":"2011","journal-title":"CA Cancer J Clin"},{"key":"10.1002\/jcsm.12029-BIB0002|jcsm12029-cit-0002","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/bjc.1997.17","article-title":"Changes in nutritional status associated with unresectable pancreatic cancer","volume":"75","author":"Wigmore","year":"1997","journal-title":"Br J Cancer"},{"key":"10.1002\/jcsm.12029-BIB0003|jcsm12029-cit-0003","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/nrclinonc.2012.209","article-title":"Understanding the mechanisms and treatment options in cancer cachexia","volume":"10","author":"Fearon","year":"2013","journal-title":"Nat Rev Clin Oncol"},{"key":"10.1002\/jcsm.12029-BIB0004|jcsm12029-cit-0004","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/S0149-2918(05)80001-3","article-title":"Prognostic effect of weight loss prior to chemotherapy in cancer patients","volume":"69","author":"Dewys","year":"1980","journal-title":"ECOG Am. J. Med"},{"key":"10.1002\/jcsm.12029-BIB0005|jcsm12029-cit-0005","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/S1470-2045(10)70218-7","article-title":"Definition and classification of cancer cachexia: an international consensus","volume":"12","author":"Fearon","year":"2011","journal-title":"Lancet Oncol"},{"key":"10.1002\/jcsm.12029-BIB0006|jcsm12029-cit-0006","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.cmet.2012.06.011","article-title":"Cancer cachexia: mediators, signaling, and metabolic pathways","volume":"16","author":"Fearon","year":"2012","journal-title":"Cell Metab"},{"key":"10.1002\/jcsm.12029-BIB0007|jcsm12029-cit-0007","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1152\/physrev.00016.2008","article-title":"Mechanisms of cancer cachexia","volume":"89","author":"Tisdale","year":"2009","journal-title":"Physiol Rev"},{"key":"10.1002\/jcsm.12029-BIB0008|jcsm12029-cit-0008","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1001\/archsurg.1988.01400320078016","article-title":"Current concepts of protein turnover and amino acid transport in liver and skeletal muscle during sepsis","volume":"123","author":"Hasselgren","year":"1988","journal-title":"Arch Surg"},{"key":"10.1002\/jcsm.12029-BIB0009|jcsm12029-cit-0009","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1007\/PL00012351","article-title":"Pancreatic cancer as a model: inflammatory mediators, acute-phase response, and cancer cachexia","volume":"23","author":"Fearon","year":"1999","journal-title":"World J Surg"},{"key":"10.1002\/jcsm.12029-BIB0010|jcsm12029-cit-0010","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1002\/bjs.1800840214","article-title":"Contribution of anorexia and hypermetabolism to weight loss in anicteric patients with pancreatic cancer","volume":"84","author":"Wigmore","year":"1997","journal-title":"Br J Surg"},{"key":"10.1002\/jcsm.12029-BIB0011|jcsm12029-cit-0011","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1097\/00000658-199802000-00015","article-title":"Albumin synthesis rates are not decreased in hypoalbuminemic cachectic cancer patients with an ongoing acute-phase protein response","volume":"227","author":"Fearon","year":"1998","journal-title":"Ann Surg"},{"key":"10.1002\/jcsm.12029-BIB0012|jcsm12029-cit-0012","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1093\/jn\/128.8.1355","article-title":"Fibrinogen synthesis is elevated in fasting cancer patients with an acute phase response","volume":"128","author":"Preston","year":"1998","journal-title":"J Nutr"},{"key":"10.1002\/jcsm.12029-BIB0013|jcsm12029-cit-0013","doi-asserted-by":"crossref","first-page":"E707","DOI":"10.1152\/ajpendo.2000.279.3.E707","article-title":"Liver export protein synthetic rates are increased by oral meal feeding in weight-losing cancer patients","volume":"279","author":"Barber","year":"2000","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1002\/jcsm.12029-BIB0014|jcsm12029-cit-0014","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1042\/cs0890651","article-title":"Comparison of bio-impedance spectroscopy and multi-frequency bio-impedance analysis for the assessment of extracellular and total body water in surgical patients","volume":"89","author":"Hannan","year":"1995","journal-title":"Clin Sci"},{"key":"10.1002\/jcsm.12029-BIB0015|jcsm12029-cit-0015","first-page":"62","article-title":"Effect of major liver resection on hepatic ureagenesis in humans","volume":"293","author":"Poll","year":"2007","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1002\/jcsm.12029-BIB0016|jcsm12029-cit-0016","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1093\/ajcn\/81.5.1142","article-title":"Plasma arginine concentrations are reduced in cancer patients: evidence for arginine deficiency?","volume":"81","author":"Vissers","year":"2005","journal-title":"Am J Clin Nutr"},{"key":"10.1002\/jcsm.12029-BIB0017|jcsm12029-cit-0017","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1006\/abio.1999.4112","article-title":"Determination of amino acid isotope enrichment using liquid chromatography-mass spectrometry","volume":"271","author":"Eijk","year":"1999","journal-title":"Anal Biochem"},{"key":"10.1002\/jcsm.12029-BIB0018|jcsm12029-cit-0018","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1002\/rcm.4402","article-title":"Improved measurement of protein synthesis in human subjects using 2H-phenylalanine isotopomers and gas chromatography\/mass spectrometry","volume":"24","author":"Preston","year":"2010","journal-title":"Rapid Commun Mass Spectrom"},{"key":"10.1002\/jcsm.12029-BIB0019|jcsm12029-cit-0019","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1152\/ajpgi.00355.2007","article-title":"Phenylalanine and tyrosine kinetics in compensated liver cirrhosis: effects of meal ingestion","volume":"295","author":"Tessari","year":"2008","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1002\/jcsm.12029-BIB0020|jcsm12029-cit-0020","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/0022-4804(87)90123-5","article-title":"The effects of gastrointestinal malignancy on whole body protein metabolism","volume":"43","author":"Borzotta","year":"1987","journal-title":"J Surg Res"},{"key":"10.1002\/jcsm.12029-BIB0021|jcsm12029-cit-0021","first-page":"1226","article-title":"Contribution of elevated protein turnover and anorexia to cachexia in patients with hepatocellular carcinoma","volume":"50","author":"O'Keefe","year":"1990","journal-title":"Cancer Res"},{"key":"10.1002\/jcsm.12029-BIB0022|jcsm12029-cit-0022","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1365-2796.2006.01663.x","article-title":"Abnormalities of whole body protein turnover, muscle metabolism and levels of metabolic hormones in patients with chronic heart failure","volume":"260","author":"N\u00f8rrelund","year":"2006","journal-title":"J Intern Med"},{"key":"10.1002\/jcsm.12029-BIB0023|jcsm12029-cit-0023","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1042\/cs0940321","article-title":"Whole body protein metabolism in human pulmonary tuberculosis and undernutrition: evidence for anabolic block in tuberculosis","volume":"94","author":"Macallan","year":"1998","journal-title":"Clin Sci"},{"key":"10.1002\/jcsm.12029-BIB0024|jcsm12029-cit-0024","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.clnu.2012.04.006","article-title":"Enhanced anabolic response to milk protein sip feeding in elderly subjects with COPD is associated with a reduced splanchnic extraction of multiple amino acids","volume":"31","author":"Engelen","year":"2012","journal-title":"Clin Nutr"},{"key":"10.1002\/jcsm.12029-BIB0025|jcsm12029-cit-0025","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1093\/ajcn\/83.4.829","article-title":"Greater whole-body myofibrillar protein breakdown in cachectic patients with chronic obstructive pulmonary disease","volume":"83","author":"Rutten","year":"2006","journal-title":"Am J Clin Nutr"},{"key":"10.1002\/jcsm.12029-BIB0026|jcsm12029-cit-0026","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1002\/(SICI)1097-0142(19980101)82:1<42::AID-CNCR5>3.0.CO;2-M","article-title":"Effects of cachexia due to cancer on whole body and skeletal muscle protein turnover","volume":"82","author":"Federica","year":"1998","journal-title":"Cancer"},{"key":"10.1002\/jcsm.12029-BIB0027|jcsm12029-cit-0027","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.clnu.2012.05.003","article-title":"Normal protein anabolic response to hyperaminoacidemia in insulin-resistant patients with lung cancer cachexia","volume":"31","author":"Winter","year":"2012","journal-title":"Clin Nutr"},{"key":"10.1002\/jcsm.12029-BIB0028|jcsm12029-cit-0028","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1177\/030089160008600508","article-title":"Effect of total parenteral nutrition on the protein kinetics of patients with cancer cachexia","volume":"86","author":"Bozzetti","year":"2000","journal-title":"Tumori"},{"key":"10.1002\/jcsm.12029-BIB0029|jcsm12029-cit-0029","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.3945\/ajcn.112.045708","article-title":"Effect of tumor burden and subsequent surgical resection on skeletal muscle mass and protein turnover in colorectal cancer patients","volume":"96","author":"Williams","year":"2012","journal-title":"Am J Clin Nutr"},{"key":"10.1002\/jcsm.12029-BIB0030|jcsm12029-cit-0030","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.clnu.2013.06.014","article-title":"Hydrolyzed casein and whey protein meals comparably stimulate net whole-body protein synthesis in COPD patients with nutritional depletion without an additional effect of leucine co-ingestion","volume":"33","author":"Jonker","year":"2014","journal-title":"Clin Nutr"},{"key":"10.1002\/jcsm.12029-BIB0031|jcsm12029-cit-0031","doi-asserted-by":"crossref","first-page":"997","DOI":"10.3945\/ajcn.110.008102","article-title":"Whey protein stimulates postprandial muscle protein accretion more effectively than do casein and casein hydrolysate in older men","volume":"93","author":"Pennings","year":"2011","journal-title":"Am J Clin Nutr"},{"key":"10.1002\/jcsm.12029-BIB0032|jcsm12029-cit-0032","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1475-2891-13-9","article-title":"Postprandial muscle protein synthesis is higher after a high whey protein, leucine-enriched supplement than after a dairy-like product in healthy older people: a randomized controlled trial","volume":"13","author":"Luiking","year":"2014","journal-title":"Nutr J"},{"key":"10.1002\/jcsm.12029-BIB0033|jcsm12029-cit-0033","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1097\/SPC.0b013e328331e91c","article-title":"The pathophysiology of cachexia in chronic obstructive pulmonary disease","volume":"3","author":"Schols","year":"2009","journal-title":"Curr Opin Support Palliat Care"},{"key":"10.1002\/jcsm.12029-BIB0034|jcsm12029-cit-0034","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1152\/ajpendo.00517.2011","article-title":"Amino acid absorption and subsequent muscle protein accretion following graded intakes of whey protein in elderly men","volume":"302","author":"Pennings","year":"2012","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1002\/jcsm.12029-BIB0035|jcsm12029-cit-0035","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/0277-5379(91)90051-E","article-title":"Effect on whole-body protein synthesis after institution of intravenous nutrition in cancer and non-cancer patients who lose weight","volume":"27","author":"Hyltander","year":"1991","journal-title":"Eur J Cancer"},{"key":"10.1002\/jcsm.12029-BIB0036|jcsm12029-cit-0036","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1002\/1097-0142(19860701)58:1<147::AID-CNCR2820580126>3.0.CO;2-I","article-title":"Improved protein kinetics and albumin synthesis by branched chain amino acid-enriched total parenteral nutrition in cancer cachexia: a prospective randomized crossover trial","volume":"58","author":"John","year":"1986","journal-title":"Cancer"},{"key":"10.1002\/jcsm.12029-BIB0037|jcsm12029-cit-0037","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1097\/MCO.0b013e3283319399","article-title":"Muscle atrophy in cachexia: can dietary protein tip the balance?","volume":"12","author":"Op den Kamp","year":"2009","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"10.1002\/jcsm.12029-BIB0038|jcsm12029-cit-0038","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1093\/ajcn\/84.5.1163","article-title":"Dietary patterns in patients with advanced cancer: implications for anorexia-cachexia therapy","volume":"84","author":"Hutton","year":"2006","journal-title":"Am J Clin Nutr"},{"key":"10.1002\/jcsm.12029-BIB0039|jcsm12029-cit-0039","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1139\/H08-075","article-title":"A practical and precise approach to quantification of body composition in cancer patients using computed tomography images acquired during routine care","volume":"33","author":"Mourtzakis","year":"2008","journal-title":"Applied physiology, nutrition, and metabolism\u2009=\u2009Physiologie appliqu\u00e9e, nutrition et m\u00e9tabolisme"},{"key":"10.1002\/jcsm.12029-BIB0040|jcsm12029-cit-0040","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/ejcn.2014.203","article-title":"Bioelectrical impedance analysis to estimate body composition in surgical and oncological patients: a systematic review","volume":"69","author":"Haverkort","year":"2015","journal-title":"Eur J Clin Nutr"}],"container-title":["Journal of Cachexia, Sarcopenia and Muscle"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcsm.12029","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1002\/jcsm.12029\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,3]],"date-time":"2021-07-03T11:35:50Z","timestamp":1625312150000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcsm.12029"}},"subtitle":["Feeding and protein metabolism in pancreatic cancer cachexia"],"short-title":[],"issued":{"date-parts":[[2015,4,20]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,9]]}},"URL":"https:\/\/doi.org\/10.1002\/jcsm.12029","archive":["Portico"],"relation":{},"ISSN":["2190-5991"],"issn-type":[{"value":"2190-5991","type":"print"}],"subject":[],"published":{"date-parts":[[2015,4,20]]}}}