{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:10:22Z","timestamp":1790871022039,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":84,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"name":"American College of Gastroenterology Institute 2011"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Cachexia, Sarcopenia and Muscle"],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.1002\/jcsm.12039","type":"journal-article","created":{"date-parts":[[2015,6,11]],"date-time":"2015-06-11T01:35:55Z","timestamp":1433986555000},"page":"126-135","source":"Crossref","is-referenced-by-count":471,"title":["Sarcopenic obesity and myosteatosis are associated with higher mortality in patients with cirrhosis"],"prefix":"10.1002","volume":"7","author":[{"given":"Aldo J.","family":"Montano-Loza","sequence":"first","affiliation":[{"name":"Division of Gastroenterology & Liver Unit; University of Alberta Hospital; Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Angulo","sequence":"additional","affiliation":[{"name":"Division of Digestive Diseases & Nutrition; University of Kentucky Medical Center; Lexington KY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Meza-Junco","sequence":"additional","affiliation":[{"name":"Department of Oncology; Cross Cancer Institute; Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla M. M.","family":"Prado","sequence":"additional","affiliation":[{"name":"Department of Agricultural; Food and Nutritional Sciences; Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael B.","family":"Sawyer","sequence":"additional","affiliation":[{"name":"Department of Oncology; Cross Cancer Institute; Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Crystal","family":"Beaumont","sequence":"additional","affiliation":[{"name":"Department of Oncology; Cross Cancer Institute; Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Esfandiari","sequence":"additional","affiliation":[{"name":"Department of Oncology; Cross Cancer Institute; Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mang","family":"Ma","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology & Liver Unit; University of Alberta Hospital; Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vickie E.","family":"Baracos","sequence":"additional","affiliation":[{"name":"Department of Oncology; Cross Cancer Institute; Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,6,9]]},"reference":[{"key":"10.1002\/jcsm.12039-BIB0001|jcsm12039-cit-0001","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1753-4887.2011.00456.x","article-title":"Global nutrition transition and the pandemic of obesity in developing countries","volume":"70","author":"Popkin","year":"2012","journal-title":"Nutr Rev"},{"key":"10.1002\/jcsm.12039-BIB0002|jcsm12039-cit-0002","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1053\/j.gastro.2007.03.052","article-title":"The epidemiology of obesity","volume":"132","author":"Ogden","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1002\/jcsm.12039-BIB0003|jcsm12039-cit-0003","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1053\/j.gastro.2009.05.007","article-title":"Weight-related effects on disease progression in the hepatitis C antiviral long-term treatment against cirrhosis trial","volume":"137","author":"Everhart","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1002\/jcsm.12039-BIB0004|jcsm12039-cit-0004","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1053\/jhep.2002.31782","article-title":"Risk factors of fibrosis in alcohol-induced liver disease","volume":"35","author":"Raynard","year":"2002","journal-title":"Hepatology"},{"key":"10.1002\/jcsm.12039-BIB0005|jcsm12039-cit-0005","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1002\/hep.24418","article-title":"Obesity is an independent risk factor for clinical decompensation in patients with cirrhosis","volume":"54","author":"Berzigotti","year":"2010","journal-title":"Hepatology"},{"key":"10.1002\/jcsm.12039-BIB0006|jcsm12039-cit-0006","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1097\/MCG.0b013e318293a825","article-title":"Sarcopenia as a prognostic index of nutritional status in concurrent cirrhosis and hepatocellular carcinoma","volume":"47","author":"Meza-Junco","year":"2013","journal-title":"J Clin Gastroenterol"},{"key":"10.1002\/jcsm.12039-BIB0007|jcsm12039-cit-0007","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1111\/ajt.12221","article-title":"Impact of sarcopenia on survival in patients undergoing living donor liver transplantation","volume":"13","author":"Kaido","year":"2013","journal-title":"American Journal of Transplantation: Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons"},{"key":"10.1002\/jcsm.12039-BIB0008|jcsm12039-cit-0008","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1002\/lt.23752","article-title":"Association between sarcopenia and the risk of serious infection among adults undergoing liver transplantation","volume":"19","author":"Krell","year":"2013","journal-title":"Liver Transpl"},{"key":"10.1002\/jcsm.12039-BIB0009|jcsm12039-cit-0009","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.jamcollsurg.2010.03.039","article-title":"Sarcopenia and mortality after liver transplantation","volume":"211","author":"Englesbe","year":"2010","journal-title":"J Am Coll Surg"},{"key":"10.1002\/jcsm.12039-BIB0010|jcsm12039-cit-0010","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.cgh.2011.08.028","article-title":"Muscle wasting is associated with mortality in patients with cirrhosis","volume":"10","author":"Montano-Loza","year":"2012","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1002\/jcsm.12039-BIB0011|jcsm12039-cit-0011","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1177\/0884533612469027","article-title":"Nutrition assessment and management in advanced liver disease","volume":"28","author":"Johnson","year":"2013","journal-title":"Nutr Clin Pract"},{"key":"10.1002\/jcsm.12039-BIB0012|jcsm12039-cit-0012","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1053\/j.gastro.2008.02.001","article-title":"Nutrition in end-stage liver disease: principles and practice","volume":"134","author":"O'Brien","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1002\/jcsm.12039-BIB0013|jcsm12039-cit-0013","first-page":"173","article-title":"New concepts in liver cirrhosis: clinical significance of sarcopenia in cirrhotic patients","volume":"59","author":"Montano-Loza","year":"2013","journal-title":"Minerva Gastroenterol Dietol"},{"key":"10.1002\/jcsm.12039-BIB0014|jcsm12039-cit-0014","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1097\/MCO.0000000000000046","article-title":"Muscle wasting: a nutritional criterion to prioritize patients for liver transplantation","volume":"17","author":"Montano-Loza","year":"2014","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"10.1002\/jcsm.12039-BIB0015|jcsm12039-cit-0015","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1002\/lt.23811","article-title":"Sarcopenia is a prognostic factor in living donor liver transplantation","volume":"20","author":"Masuda","year":"2014","journal-title":"Liver Transplant"},{"key":"10.1002\/jcsm.12039-BIB0016|jcsm12039-cit-0016","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1097\/MEG.0b013e328359a759","article-title":"Reversal of sarcopenia predicts survival after a transjugular intrahepatic portosystemic stent","volume":"25","author":"Tsien","year":"2013","journal-title":"Eur J Gastroen Hepat"},{"key":"10.1002\/jcsm.12039-BIB0017|jcsm12039-cit-0017","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1016\/j.jhep.2014.02.026","article-title":"Prognostic value of muscle atrophy in cirrhosis using psoas muscle thickness on computed tomography","volume":"60","author":"Durand","year":"2014","journal-title":"J Hepatol"},{"key":"10.1002\/jcsm.12039-BIB0018|jcsm12039-cit-0018","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1139\/H08-075","article-title":"A practical and precise approach to quantification of body composition in cancer patients using computed tomography images acquired during routine care","volume":"33","author":"Mourtzakis","year":"2008","journal-title":"Appl Physiol Nutr Metab"},{"key":"10.1002\/jcsm.12039-BIB0019|jcsm12039-cit-0019","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s13539-012-0069-3","article-title":"Consilience in sarcopenia of cirrhosis","volume":"3","author":"Dasarathy","year":"2012","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"10.1002\/jcsm.12039-BIB0020|jcsm12039-cit-0020","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1159\/000211949","article-title":"Frailty syndrome: a transitional state in a dynamic process","volume":"55","author":"Lang","year":"2009","journal-title":"Gerontology"},{"key":"10.1002\/jcsm.12039-BIB0021|jcsm12039-cit-0021","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1093\/oxfordjournals.aje.a009520","article-title":"Epidemiology of sarcopenia among the elderly in New Mexico","volume":"147","author":"Baumgartner","year":"1998","journal-title":"Am J Epidemiol"},{"key":"10.1002\/jcsm.12039-BIB0022|jcsm12039-cit-0022","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1007\/s00198-009-1059-y","article-title":"Sarcopenia: etiology, clinical consequences, intervention, and assessment","volume":"21","author":"Lang","year":"2010","journal-title":"Osteoporos Int"},{"key":"10.1002\/jcsm.12039-BIB0023|jcsm12039-cit-0023","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1139\/H10-067","article-title":"Evolution of sarcopenia research","volume":"35","author":"Janssen","year":"2010","journal-title":"Appl Physiol Nutr Metab"},{"key":"10.1002\/jcsm.12039-BIB0024|jcsm12039-cit-0024","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1152\/japplphysiol.00627.2006","article-title":"Sarcopenic obesity and inflammation in the InCHIANTI study","volume":"102","author":"Schrager","year":"2007","journal-title":"J Appl Physiol"},{"key":"10.1002\/jcsm.12039-BIB0025|jcsm12039-cit-0025","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1111\/j.1365-2265.2012.04433.x","article-title":"Relationships between sarcopenic obesity and insulin resistance, inflammation, and vitamin D status: the Korean Sarcopenic Obesity Study","volume":"78","author":"Kim","year":"2013","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.1002\/jcsm.12039-BIB0026|jcsm12039-cit-0026","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1093\/ajcn\/81.4.903","article-title":"Adipose tissue in muscle: a novel depot similar in size to visceral adipose tissue","volume":"81","author":"Gallagher","year":"2005","journal-title":"Am J Clin Nutr"},{"key":"10.1002\/jcsm.12039-BIB0027|jcsm12039-cit-0027","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1126\/science.1082889","article-title":"Mitochondrial dysfunction in the elderly: possible role in insulin resistance","volume":"300","author":"Petersen","year":"2003","journal-title":"Science"},{"key":"10.1002\/jcsm.12039-BIB0028|jcsm12039-cit-0028","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1093\/gerona\/60.3.324","article-title":"Muscle mass, muscle strength, and muscle fat infiltration as predictors of incident mobility limitations in well-functioning older persons","volume":"60","author":"Visser","year":"2005","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"10.1002\/jcsm.12039-BIB0029|jcsm12039-cit-0029","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1152\/jappl.1998.85.1.115","article-title":"Cadaver validation of skeletal muscle measurement by magnetic resonance imaging and computerized tomography","volume":"85","author":"Mitsiopoulos","year":"1998","journal-title":"J Appl Physiol"},{"key":"10.1002\/jcsm.12039-BIB0030|jcsm12039-cit-0030","first-page":"53","article-title":"Adipose tissue volume determinations in women by computed tomography: technical considerations","volume":"10","author":"Kvist","year":"1986","journal-title":"Int J Obes"},{"key":"10.1002\/jcsm.12039-BIB0031|jcsm12039-cit-0031","first-page":"570","article-title":"Measuring visceral adipose tissue content from contrast enhanced computed tomography","volume":"20","author":"Vehmas","year":"1996","journal-title":"Int J Obes Relat Metab Disord"},{"key":"10.1002\/jcsm.12039-BIB0032|jcsm12039-cit-0032","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1200\/JCO.2012.45.2722","article-title":"Cancer cachexia in the age of obesity: skeletal muscle depletion is a powerful prognostic factor, independent of body mass index","volume":"31","author":"Martin","year":"2013","journal-title":"J Clin Oncol"},{"key":"10.1002\/jcsm.12039-BIB0033|jcsm12039-cit-0033","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s13539-012-0087-1","article-title":"Cancer cachexia: impact, mechanisms and emerging treatments","volume":"4","author":"Vaughan","year":"2013","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"10.1002\/jcsm.12039-BIB0034|jcsm12039-cit-0034","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.cgh.2010.06.024","article-title":"Cirrhotic patients are at risk for health care-associated bacterial infections","volume":"8","author":"Merli","year":"2010","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1002\/jcsm.12039-BIB0035|jcsm12039-cit-0035","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1172\/JCI110240","article-title":"Hepatic, gut, and renal substrate flux rates in patients with hepatic cirrhosis","volume":"68","author":"Owen","year":"1981","journal-title":"J Clin Invest"},{"key":"10.1002\/jcsm.12039-BIB0036|jcsm12039-cit-0036","first-page":"239","article-title":"Nutritional therapy in patients with liver cirrhosis","volume":"46","author":"Kondrup","year":"1992","journal-title":"Eur J Clin Nutr"},{"key":"10.1002\/jcsm.12039-BIB0037|jcsm12039-cit-0037","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1097\/MCO.0b013e32834dd297","article-title":"Chronic low-grade inflammation and age-related sarcopenia","volume":"15","author":"Beyer","year":"2012","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"10.1002\/jcsm.12039-BIB0038|jcsm12039-cit-0038","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/j.jhep.2010.08.032","article-title":"Sarcopenia associated with portosystemic shunting is reversed by follistatin","volume":"54","author":"Dasarathy","year":"2011","journal-title":"J Hepatol"},{"key":"10.1002\/jcsm.12039-BIB0039|jcsm12039-cit-0039","doi-asserted-by":"crossref","first-page":"E221","DOI":"10.1152\/ajpendo.2001.280.2.E221","article-title":"Myostatin inhibits cell proliferation and protein synthesis in C2C12 muscle cells","volume":"280","author":"Taylor","year":"2001","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1002\/jcsm.12039-BIB0040|jcsm12039-cit-0040","doi-asserted-by":"crossref","first-page":"E983","DOI":"10.1152\/ajpendo.00183.2012","article-title":"Hyperammonemia-mediated autophagy in skeletal muscle contributes to sarcopenia of cirrhosis","volume":"303","author":"Qiu","year":"2012","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1002\/jcsm.12039-BIB0041|jcsm12039-cit-0041","doi-asserted-by":"crossref","first-page":"S95","DOI":"10.1016\/S0168-8278(13)60223-8","article-title":"New cutoff values for sarcopenia for predicting 6-months mortality in cirrhotic patients","volume":"58","author":"Montano-Loza","year":"2013","journal-title":"J Hepatol"},{"key":"10.1002\/jcsm.12039-BIB0042|jcsm12039-cit-0042","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1002\/lt.23863","article-title":"Severe muscle depletion predicts postoperative length of stay but is not associated with survival after liver transplantation","volume":"20","author":"Montano-Loza","year":"2014","journal-title":"Liver Transpl"}],"container-title":["Journal of Cachexia, Sarcopenia and Muscle"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcsm.12039","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/jcsm.12039","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,3]],"date-time":"2021-07-03T07:53:49Z","timestamp":1625298829000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcsm.12039"}},"subtitle":["Sarcopenic obesity and myosteatosis in cirrhosis"],"short-title":[],"issued":{"date-parts":[[2015,6,9]]},"references-count":42,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,5]]}},"URL":"https:\/\/doi.org\/10.1002\/jcsm.12039","archive":["Portico"],"relation":{},"ISSN":["2190-5991"],"issn-type":[{"value":"2190-5991","type":"print"}],"subject":[],"published":{"date-parts":[[2015,6,9]]}}}