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Further, it is unknown if the prognostic role of sarcopenia differs between males and females, and obese and non\u2010obese individuals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A population\u2010based cohort study among 4425 older adults from the Third National Health and Nutrition Survey (1988\u20131994). Muscle mass was quantified using bioimpedance analysis, and muscle function was quantified using gait speed. Multivariable\u2010adjusted Cox regression analysis examined the relationship between sarcopenia and mortality outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean age of study participants was 70.1\u2009years. The prevalence of sarcopenia was 36.5%. Sarcopenia associated with an increased risk of all\u2010cause mortality [hazard ratio (HR): 1.29 (95% confidence interval (95% CI): 1.13\u20131.47); <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001] among males and females. Sarcopenia associated with an increased risk of cardiovascular\u2010specific mortality among females [HR: 1.61 (95% CI: 1.22\u20132.12); <jats:italic>P<\/jats:italic>\u2009=\u20090.001], but not among males [HR: 1.07 (95% CI: 0.81\u20131.40; <jats:italic>P<\/jats:italic>\u2009=\u2009.643); <jats:italic>P<\/jats:italic><jats:sub>interaction<\/jats:sub>\u2009=\u20090.079]. Sarcopenia was not associated with cancer\u2010specific mortality among males and females [HR: 1.07 (95% CI: 0.78\u20131.89); <jats:italic>P<\/jats:italic>\u2009=\u20090.672]. Sarcopenia associated with an increased risk of mortality from other causes (i.e. non\u2010cardiovascular and non\u2010cancer) among males and females [HR: 1.32 (95% CI: 1.07\u20131.62); <jats:italic>P<\/jats:italic>\u2009=\u20090.008]. Obesity, defined using body mass index (<jats:italic>P<\/jats:italic><jats:sub>interaction<\/jats:sub>\u2009=\u20090.817) or waist circumference (<jats:italic>P<\/jats:italic><jats:sub>interaction<\/jats:sub>\u2009=\u20090.219) did not modify the relationship between sarcopenia and all\u2010cause mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Sarcopenia is a prevalent syndrome that is associated with premature mortality among community\u2010dwelling older adults. The prognostic value of sarcopenia may vary by cause\u2010specific mortality and differ between males and females.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcsm.12073","type":"journal-article","created":{"date-parts":[[2015,10,15]],"date-time":"2015-10-15T10:48:18Z","timestamp":1444906098000},"page":"290-298","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":316,"title":["Sarcopenia and mortality among a population\u2010based sample of community\u2010dwelling older adults"],"prefix":"10.1002","volume":"7","author":[{"given":"Justin C.","family":"Brown","sequence":"first","affiliation":[{"name":"Center for Clinical Epidemiology and Biostatistics University of Pennsylvania School of Medicine  Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael O.","family":"Harhay","sequence":"additional","affiliation":[{"name":"Center for Clinical Epidemiology and Biostatistics University of Pennsylvania School of Medicine  Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meera N.","family":"Harhay","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine Drexel University College of Medicine  Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,10,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/61.10.1059"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afq034"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2011.01.003"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/60.3.324"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/61.1.72"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0838.2003.00298.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.12652"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1741-6612.2010.00448.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/gln031"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejcn.2014.117"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2003.05.001"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2014.02.007"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/86.5.1339"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12603-012-0434-0"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afs194"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12603-014-0540-2"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/50A.Special_Issue.5"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2004.111"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glr070"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glr035"},{"key":"e_1_2_7_22_1","first-page":"1","article-title":"1988\u201394. 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