{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T21:00:08Z","timestamp":1789506008067,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,10,15]],"date-time":"2015-10-15T00:00:00Z","timestamp":1444867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Korean Government","award":["No. 2011-0030135"],"award-info":[{"award-number":["No. 2011-0030135"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>It has been reported that 4,4\u2032\u2010diamino\u2010diphenyl sulfone (DDS), the longtime treatment of choice for leprosy, prolongs the lifespan and increases mobility in animal models by reducing the levels of reactive oxygen species and inhibiting muscle pyruvate kinase activity. This study aimed to investigate whether sarcopenic status in leprosy survivors was influenced by recent history of DDS medication.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010one elderly female leprosy survivors were recruited. The DDS group was defined as survivors who had been taking the drug for the past year or more. Body composition measured by dual energy X\u2010ray absorptiometry, limb muscle strength, short physical performance battery, and International Physical Activity Questionnaire in Korean were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The DDS group tended to have higher skeletal muscle mass index (24.4\u2009\u00b1\u20092.7 vs. 22.6\u2009\u00b1\u20092.2%, <jats:italic>P<\/jats:italic>\u2009=\u20090.066) and regional skeletal muscle mass index in non\u2010dominant leg (8.9\u2009\u00b1\u20091.0 vs. 7.9\u2009\u00b1\u20090.9%, <jats:italic>P<\/jats:italic>\u2009=\u20090.018) than those of the control group although they had significantly worse leprosy disability than the control group (<jats:italic>P<\/jats:italic>\u2009=\u20090.027). The DDS group had greater strength than the control group in non\u2010dominant shoulder abductor, elbow flexor, hip flexor, and knee extensor (<jats:italic>P<\/jats:italic>\u2009=\u20090.005, <jats:italic>P<\/jats:italic>\u2009=\u20090.029, <jats:italic>P<\/jats:italic>\u2009=\u20090.021, and <jats:italic>P<\/jats:italic>\u2009=\u20090.002, respectively). Weekly walking amount was significantly longer (<jats:italic>P<\/jats:italic>\u2009=\u20090.020) in the DDS group than the control group. The total lifetime DDS exposure significantly correlated with skeletal muscle mass of the lower extremity in non\u2010dominant leg (<jats:italic>r<\/jats:italic>\u2009=\u20090.379, <jats:italic>P<\/jats:italic>\u2009=\u20090.015).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>DDS\u2010taking leprosy survivors had larger skeletal muscle mass and greater muscle strength over non\u2010taking survivors. There was a dose\u2013response relationship between total lifetime DDS exposure and skeletal muscle mass of lower extremity. These findings might suggest potential anti\u2010sarcopenic effects of DDS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcsm.12074","type":"journal-article","created":{"date-parts":[[2015,10,15]],"date-time":"2015-10-15T10:48:15Z","timestamp":1444906095000},"page":"322-329","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Anti\u2010sarcopenic effects of diamino\u2010diphenyl sulfone observed in elderly female leprosy survivors: a cross\u2010sectional study"],"prefix":"10.1002","volume":"7","author":[{"given":"Sang Yoon","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Medicine, College of Medicine Seoul National University  Seoul Korea"},{"name":"Department of Physical Medicine and Rehabilitation, College of Medicine Chung\u2010Ang University  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine Asan Medical Center  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee\u2010Won","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine Kangwon National University Hospital  Chuncheon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Chul","family":"Park","sequence":"additional","affiliation":[{"name":"Lee Gil Ya Cancer and Diabetes Institute Gachon University  Seongnam Korea"},{"name":"Institute of Aging Seoul National University  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In Kwon","family":"Kim","sequence":"additional","affiliation":[{"name":"Wilson Leprosy Center and Rehabilitation Hospital  Yeosu Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun G.","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, College of Medicine Seoul National University  Seoul Korea"},{"name":"Institute of Aging Seoul National University  Seoul Korea"},{"name":"Rheumatism Research Institute, Medical Research Center Seoul National University  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,10,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199406233302501"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjsm.2009.063966"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2008.07.004"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1249\/JSR.0b013e3181e93938"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1000485"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2009.08853.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afs191"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbr021"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1005078107"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archger.2013.07.013"},{"key":"e_1_2_8_12_1","doi-asserted-by":"crossref","first-page":"131","DOI":"10.47276\/lr.75.2.131","article-title":"Inter\u2010rater reliability of WHO \u2018disability\u2019 grading","volume":"75","author":"Brandsma W","year":"2004","journal-title":"Lepr. 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