{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T08:23:30Z","timestamp":1789547010627,"version":"build-2803163510"},"reference-count":51,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,11,3]],"date-time":"2015-11-03T00:00:00Z","timestamp":1446508800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004569","name":"Ministerstwo Nauki i Szkolnictwa Wy\u017cszego","doi-asserted-by":"publisher","award":["0048\/IP1\/2011\/71"],"award-info":[{"award-number":["0048\/IP1\/2011\/71"]}],"id":[{"id":"10.13039\/501100004569","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The skeletal muscle has the ability to regenerate after injury. This process is mediated mainly by the muscle specific stem cells, that is, satellite cells. In case of extensive damage or under pathological conditions, such as muscular dystrophy, the process of muscle reconstruction does not occur properly. The aim of our study was to test whether mobilized stem cells, other than satellite cells, could participate in skeletal muscle reconstruction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Experiments were performed on wild\u2010type mice and mice lacking the functional <jats:italic>Pax7<\/jats:italic> gene, that is, characterized by the very limited satellite cell population. Gastrocnemius mice muscles were injured by cardiotoxin injection, and then the animals were treated by stromal derived factor\u20101 (Sdf\u20101) with or without granulocyte\u2010colony stimulating factor (G\u2010CSF) for 4\u2009days. The muscles were subjected to thorough assessment of the tissue regeneration process using histological and <jats:italic>in vitro<\/jats:italic> methods, as well as evaluation of myogenic factors' expression at the transcript and protein levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Stromal derived factor\u20101 alone and Sdf\u20101 in combination with G\u2010CSF significantly improved the regeneration of <jats:italic>Pax7<\/jats:italic>\u2212\/\u2212 skeletal muscles. The Sdf\u20101 and G\u2010CSF treatment caused an increase in the number of mononucleated cells associated with muscle fibres. Further analysis showed that Sdf\u20101 and G\u2010CSF treatment led to the rise in the number of CD34+ and Cxcr4+ cells and expression of Cxcr7.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Stromal derived factor\u20101 and G\u2010CSF stimulated regeneration of the skeletal muscles deficient in satellite cells. We suggest that mobilized CD34+, Cxcr4+, and Cxcr7+ cells can efficiently participate in the skeletal muscle reconstruction and compensate for the lack of satellite cells.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcsm.12092","type":"journal-article","created":{"date-parts":[[2015,11,3]],"date-time":"2015-11-03T06:02:45Z","timestamp":1446530565000},"page":"483-496","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Stromal derived factor\u20101 and granulocyte\u2010colony stimulating factor treatment improves regeneration of <i>Pax7<\/i>\u2212\/\u2212 mice skeletal muscles"],"prefix":"10.1002","volume":"7","author":[{"given":"Kamil","family":"Kowalski","sequence":"first","affiliation":[{"name":"Department of Cytology, Faculty of Biology University of Warsaw  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafa\u0142","family":"Archacki","sequence":"additional","affiliation":[{"name":"Laboratory of Systems Biology, Faculty of Biology University of Warsaw  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karolina","family":"Archacka","sequence":"additional","affiliation":[{"name":"Department of Cytology, Faculty of Biology University of Warsaw  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W\u0142adys\u0142awa","family":"Stremi\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Cytology, Faculty of Biology University of Warsaw  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Paciorek","sequence":"additional","affiliation":[{"name":"Department of Cytology, Faculty of Biology University of Warsaw  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Go\u0142\u0105bek","sequence":"additional","affiliation":[{"name":"Department of Cytology, Faculty of Biology University of Warsaw  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria A.","family":"Ciemerych","sequence":"additional","affiliation":[{"name":"Department of Cytology, Faculty of Biology University of Warsaw  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edyta","family":"Brzoska","sequence":"additional","affiliation":[{"name":"Department of Cytology, Faculty of Biology University of Warsaw  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,11,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.069088"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/560629"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1006\/excr.2002.5653"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091700405"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.05.010"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07384"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/337176a0"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410340105"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.12273"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2006.10.003"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200512085"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms1508"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI20325"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvs132"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/boc.201200022"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.185.1.111"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2005-0271"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2007.02.001"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2011.18"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/312656"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/scrt54"},{"key":"e_1_2_7_23_1","first-page":"17","article-title":"[Effect of erythropoietin combined with granulocyte\u2010colony stimulating factor in the treatment of acute myocardial infarction in rats]. 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