{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T07:41:57Z","timestamp":1790235717479,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,1,18]],"date-time":"2016-01-18T00:00:00Z","timestamp":1453075200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Human ageing is a process characterized by loss of muscle mass, strength, and bone mass. We aimed to examine the efficacy of low\u2010dose creatine supplementation associated with resistance training on lean mass, strength, and bone mass in the elderly.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a 12\u2010week, parallel\u2010group, double\u2010blind, randomized, placebo\u2010controlled trial. The individuals were randomly allocated into one of the following groups: placebo plus resistance training (PL\u2009+\u2009RT) and creatine supplementation plus resistance training (CR\u2009+\u2009RT) . The participants were assessed at baseline and after 12\u2009weeks. The primary outcomes were lean mass and strength, assessed by dual energy X\u2010ray absorptiometry (DXA) and ten\u2010repetition maximal tests (10\u2009RM), respectively. Secondary outcomes included the lumbar spine, right and left femoral neck, both femur and whole body bone mineral density (BMD), and whole body bone mineral content (BMC), assessed by DXA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The CR\u2009+\u2009RT group had superior gains in lean mass when compared with the PL\u2009+\u2009RT group (<jats:italic>P<\/jats:italic>\u2009=\u20090.02). Changes in the 10\u2009RM tests in bench press and leg press exercises, body composition, BMD, and BMC of all assessed sites did not significantly differ between the groups (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Twelve weeks of low\u2010dose creatine supplementation associated with resistance training resulted in increases in lean mass in the elderly.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcsm.12094","type":"journal-article","created":{"date-parts":[[2016,1,19]],"date-time":"2016-01-19T02:09:06Z","timestamp":1453169346000},"page":"413-421","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":79,"title":["Impact of creatine supplementation in combination with resistance training on lean mass in the elderly"],"prefix":"10.1002","volume":"7","author":[{"given":"Camila Lemos","family":"Pinto","sequence":"first","affiliation":[{"name":"Laboratory of Research in Clinical Nutrition and Sports (Labince) Faculty of Nutrition Federal University of Goi\u00e1s  St 227, block 68, Setor Leste Universit\u00e1rio Goi\u00e2nia Goi\u00e1s 74.605\u2010080 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patr\u00edcia Borges","family":"Botelho","sequence":"additional","affiliation":[{"name":"Laboratory of Research in Clinical Nutrition and Sports (Labince) Faculty of Nutrition Federal University of Goi\u00e1s  St 227, block 68, Setor Leste Universit\u00e1rio Goi\u00e2nia Goi\u00e1s 74.605\u2010080 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana Alves","family":"Carneiro","sequence":"additional","affiliation":[{"name":"Faculty of Physical Education Federal University of Goi\u00e1s  Esperan\u00e7a Avenue, Campus Samambaia Goi\u00e2nia Goi\u00e1s 74.690\u2010900 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Felipe","family":"Mota","sequence":"additional","affiliation":[{"name":"Laboratory of Research in Clinical Nutrition and Sports (Labince) Faculty of Nutrition Federal University of Goi\u00e1s  St 227, block 68, Setor Leste Universit\u00e1rio Goi\u00e2nia Goi\u00e1s 74.605\u2010080 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,1,18]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"World Health Organization.Global health and ageing. 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