{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T04:59:01Z","timestamp":1790139541300,"version":"4.0.1"},"reference-count":51,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,2,2]],"date-time":"2016-02-02T00:00:00Z","timestamp":1454371200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The skeletal muscle system plays an important role in the independence of older adults. In this study we examine differences in the skeletal muscle transcriptome between healthy young and older subjects and (pre\u2010)frail older adults. Additionally, we examine the effect of resistance\u2010type exercise training on the muscle transcriptome in healthy older subjects and (pre\u2010)frail older adults.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Baseline transcriptome profiles were measured in muscle biopsies collected from 53 young, 73 healthy older subjects, and 61 frail older subjects. Follow\u2010up samples from these frail older subjects (31 samples) and healthy older subjects (41 samples) were collected after 6 months of progressive resistance\u2010type exercise training. Frail older subjects trained twice per week and the healthy older subjects trained three times per week.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At baseline genes related to mitochondrial function and energy metabolism were differentially expressed between older and young subjects, as well as between healthy and frail older subjects. Three hundred seven genes were differentially expressed after training in both groups. Training affected expression levels of genes related to extracellular matrix, glucose metabolism ,and vascularization. Expression of genes that were modulated by exercise training was indicative of muscle strength at baseline. Genes that strongly correlated with strength belonged to the protocadherin gamma gene cluster (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.73).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our data suggest significant remaining plasticity of ageing skeletal muscle to adapt to resistance\u2010type exercise training. Some age\u2010related changes in skeletal muscle gene expression appear to be partially reversed by prolonged resistance\u2010type exercise training. The protocadherin gamma gene cluster may be related to muscle denervation and re\u2010innervation in ageing muscle.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcsm.12099","type":"journal-article","created":{"date-parts":[[2016,2,3]],"date-time":"2016-02-03T14:55:25Z","timestamp":1454511325000},"page":"604-614","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":80,"title":["Expression of protocadherin gamma in skeletal muscle tissue is associated with age and muscle weakness"],"prefix":"10.1002","volume":"7","author":[{"given":"Roland W. 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E. J.","family":"Hooiveld","sequence":"additional","affiliation":[{"name":"Top Institute Food and Nutrition Wageningen the Netherlands"},{"name":"Division of Human Nutrition Wageningen University Wageningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John P. M.","family":"van Duynhoven","sequence":"additional","affiliation":[{"name":"Laboratory of Biophysics Wageningen University Wageningen the Netherlands"},{"name":"Netherlands Metabolomics Centre Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James A.","family":"Timmons","sequence":"additional","affiliation":[{"name":"King's College London London UK"},{"name":"XRgenomics Ltd. London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lex B.","family":"Verdijk","sequence":"additional","affiliation":[{"name":"Top Institute Food and Nutrition Wageningen the Netherlands"},{"name":"Department of Human Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism Maastricht University Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisette C. P. G. M.","family":"de Groot","sequence":"additional","affiliation":[{"name":"Top Institute Food and Nutrition Wageningen the Netherlands"},{"name":"Division of Human Nutrition Wageningen University Wageningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc J. 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