{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T05:19:43Z","timestamp":1787980783302,"version":"build-2784847793"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,4,12]],"date-time":"2016-04-12T00:00:00Z","timestamp":1460419200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Sarcopenia is known to be related to an increased risk of chemotherapy toxicity and to a poor prognosis in patients with malignancy. We assessed the prognostic role of sarcopenia in patients with diffuse large B\u2010cell lymphoma (DLBCL).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In total, 187 consecutive patients with DLBCL treated with induction rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone (R\u2010CHOP) immunochemotherapy were reviewed. Sarcopenia was defined as the lowest sex\u2010specific quartile of the skeletal muscle index, calculated by dividing the pectoralis muscle area by the height. Clinical outcomes were compared between the sarcopenic and non\u2010sarcopenic groups. A nomogram was constructed from the Cox regression model for overall survival (OS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Treatment\u2010related mortality (21.7 vs. 5.0%, <jats:italic>P<\/jats:italic>\u2009=\u20090.002) and early discontinuation of treatment (32.6 vs. 14.9%, <jats:italic>P<\/jats:italic>\u2009=\u20090.008) were more common in the sarcopenic group than in the non\u2010sarcopenic group. The 5\u2009year progression\u2010free survival (PFS) rates were 35.3% in the sarcopenic group and 65.8% in the non\u2010sarcopenic group (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). The 5\u2009year OS rates were 37.3% in the sarcopenic group and 68.1% in the non\u2010sarcopenic group (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Sarcopenia and the five variables of the International Prognostic Index (IPI) were independent prognostic factors in a multivariate analysis for PFS and OS and were used to construct the nomogram. The calibration plot showed good agreement between the nomogram predictions and actual observations. The <jats:italic>c<\/jats:italic> index of the nomogram (0.80) was higher than those of other prognostic indices (IPI, 0.77, <jats:italic>P<\/jats:italic>\u2009=\u20090.009; revised\u2010IPI, 0.74, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001; National Comprehensive Cancer Network\u2010IPI, 0.77, <jats:italic>P<\/jats:italic>\u2009=\u20090.062).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Sarcopenia is associated with intolerance to standard R\u2010CHOP chemotherapy as well as a poor prognosis. Moreover, sarcopenia itself can be included in prognostic models in DLBCL.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcsm.12115","type":"journal-article","created":{"date-parts":[[2016,4,13]],"date-time":"2016-04-13T05:14:02Z","timestamp":1460524442000},"page":"567-576","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":105,"title":["Prognostic impact of sarcopenia in patients with diffuse large B\u2010cell lymphoma treated with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone"],"prefix":"10.1002","volume":"7","author":[{"given":"Se\u2010Il","family":"Go","sequence":"first","affiliation":[{"name":"Division of Hematology\u2010Oncology, Department of Internal Medicine Gyeongsang National University Hospital, Gyeongsang National University School of Medicine  Gangnam\u2010ro 79 Jinju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi Jung","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Radiology Gyeongsang National University Hospital, Gyeongsang National University School of Medicine  Gangnam\u2010ro 79 Jinju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haa\u2010Na","family":"Song","sequence":"additional","affiliation":[{"name":"Division of Hematology\u2010Oncology, Department of Internal Medicine Gyeongsang National University Hospital, Gyeongsang National University School of Medicine  Gangnam\u2010ro 79 Jinju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoon\u2010Gu","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Hematology\u2010Oncology, Department of Internal Medicine Gyeongsang National University Hospital, Gyeongsang National University School of Medicine  Gangnam\u2010ro 79 Jinju Korea"},{"name":"Gyeongsang Institute of Health Sciences  Gangnam\u2010ro 79 Jinju 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