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A progressive decline in muscle mass and strength occurs with ageing and in some individuals configures the syndrome of \u2018sarcopenia\u2019, a condition that impairs mobility, challenges autonomy, and is a risk factor for mortality. The mechanisms leading to sarcopenia as well as myopathies are still little understood. The Human Skeletal Muscle Proteome Project was initiated with the aim to characterize muscle proteins and how they change with ageing and disease. We conducted an extensive review of the literature and analysed publically available protein databases. A systematic search of peer\u2010reviewed studies was performed using PubMed. Search terms included \u2018human\u2019, \u2018skeletal muscle\u2019, \u2018proteome\u2019, \u2018proteomic(s)\u2019, and \u2018mass spectrometry\u2019, \u2018liquid chromatography\u2010mass spectrometry (LC\u2010MS\/MS)\u2019. A catalogue of 5431 non\u2010redundant muscle proteins identified by mass spectrometry\u2010based proteomics from 38 peer\u2010reviewed scientific publications from 2002 to November 2015 was created. We also developed a nosology system for the classification of muscle proteins based on localization and function. Such inventory of proteins should serve as a useful background reference for future research on changes in muscle proteome assessed by quantitative mass spectrometry\u2010based proteomic approaches that occur with ageing and diseases. This classification and compilation of the human skeletal muscle proteome can be used for the identification and quantification of proteins in skeletal muscle to discover new mechanisms for sarcopenia and specific muscle diseases that can be targeted for the prevention and treatment.<\/jats:p>","DOI":"10.1002\/jcsm.12121","type":"journal-article","created":{"date-parts":[[2016,8,3]],"date-time":"2016-08-03T10:51:28Z","timestamp":1470221488000},"page":"5-18","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":97,"title":["The Human Skeletal Muscle Proteome Project: a reappraisal of the current literature"],"prefix":"10.1002","volume":"8","author":[{"given":"Marta","family":"Gonzalez\u2010Freire","sequence":"first","affiliation":[{"name":"National Institute on Aging National Institutes of Health  Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard D.","family":"Semba","sequence":"additional","affiliation":[{"name":"Wilmer Eye Institute Johns Hopkins University School of Medicine  Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ceereena","family":"Ubaida\u2010Mohien","sequence":"additional","affiliation":[{"name":"National Institute on Aging National Institutes of Health  Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Fabbri","sequence":"additional","affiliation":[{"name":"National Institute on Aging National Institutes of Health  Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Scalzo","sequence":"additional","affiliation":[{"name":"National Institute on Aging National Institutes of Health  Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurt","family":"H\u00f8jlund","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Odense University Hospital  Odense Denmark"},{"name":"Institute of Clinical Research and Institute of Molecular Medicine University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig","family":"Dufresne","sequence":"additional","affiliation":[{"name":"Thermo Fisher Scientific  West Palm Beach FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexey","family":"Lyashkov","sequence":"additional","affiliation":[{"name":"National Institute on Aging National Institutes of Health  Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Ferrucci","sequence":"additional","affiliation":[{"name":"National Institute on Aging National Institutes of Health  Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,8,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2000.89.1.81"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2014.00208"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glu013"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glu012"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2015.09.005"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glu181"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-015-0654-7"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13395-015-0059-1"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.2015.1094052"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40279-013-0081-6"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr301151m"},{"key":"e_1_2_8_13_1","first-page":"511","article-title":"Muscle electrolytes in man. 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