{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T14:05:58Z","timestamp":1790431558203,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,8,5]],"date-time":"2016-08-05T00:00:00Z","timestamp":1470355200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Cachexia affects the majority with advanced cancer. Based on current demographic and clinical factors, it is not possible to predict who will develop cachexia or not. Such variation may, in part, be due to genotype. It has recently been proposed to extend the diagnostic criteria for cachexia to include a direct measure of low skeletal muscle index (LSMI) in addition to weight loss (WL). We aimed to explore our panel of candidate single nucleotide polymorphism (SNPs) for association with WL +\/\u2212 computerized tomography\u2010defined LSMI. We also explored whether the transcription in muscle of identified genes was altered according to such cachexia phenotype<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective cohort study design was used. Analysis explored associations of candidate SNPs with WL (<jats:italic>n<\/jats:italic>\u2009=\u20091276) and WL\u2009+\u2009LSMI (<jats:italic>n<\/jats:italic>\u2009=\u2009943). Human muscle transcriptome (<jats:italic>n<\/jats:italic>\u2009=\u2009134) was analysed using an Agilent platform.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Single nucleotide polymorphisms in the following genes showed association with WL alone: GCKR, LEPR, SELP, ACVR2B, TLR4, FOXO3, IGF1, CPN1, APOE, FOXO1, and GHRL. SNPs in LEPR, ACVR2B, TNF, and ACE were associated with concurrent WL\u2009+\u2009LSMI. There was concordance between muscle\u2010specific expression for ACVR2B, FOXO1 and 3, LEPR, GCKR, and TLR4 genes and LSMI and\/or WL (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The rs1799964 in the TNF gene and rs4291 in the ACE gene are new associations when the definition of cachexia is based on a combination of WL and LSMI. These findings focus attention on pro\u2010inflammatory cytokines and the renin\u2013angiotensin system as biomarkers\/mediators of muscle wasting in cachexia.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcsm.12138","type":"journal-article","created":{"date-parts":[[2016,8,5]],"date-time":"2016-08-05T09:30:31Z","timestamp":1470389431000},"page":"122-130","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["New genetic signatures associated with cancer cachexia as defined by low skeletal muscle index and weight loss"],"prefix":"10.1002","volume":"8","author":[{"given":"Neil","family":"Johns","sequence":"first","affiliation":[{"name":"Department of Clinical and Surgical Sciences University of Edinburgh  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia","family":"Stretch","sequence":"additional","affiliation":[{"name":"Department of Oncology University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin H.L.","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Surgery University Hospital Derby  Derby UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tora S.","family":"Solheim","sequence":"additional","affiliation":[{"name":"Department of Cancer Research and Molecular Medicine Norwegian University of Science and Technology  Trondheim Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sveinung","family":"S\u00f8rhaug","sequence":"additional","affiliation":[{"name":"Department of Cancer Research and Molecular Medicine Norwegian University of Science and Technology  Trondheim Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan A.","family":"Stephens","sequence":"additional","affiliation":[{"name":"Department of Clinical and Surgical Sciences University of Edinburgh  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Gioulbasanis","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology University Hospital of Larissa  Larissa Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1349-9229","authenticated-orcid":false,"given":"Richard J.E.","family":"Skipworth","sequence":"additional","affiliation":[{"name":"Department of Clinical and Surgical Sciences University of Edinburgh  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.A. Christopher","family":"Deans","sequence":"additional","affiliation":[{"name":"Department of Clinical and Surgical Sciences University of Edinburgh  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Vigano","sequence":"additional","affiliation":[{"name":"University of McGill  Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James A.","family":"Ross","sequence":"additional","affiliation":[{"name":"Department of Clinical and Surgical Sciences University of Edinburgh  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver F.","family":"Bathe","sequence":"additional","affiliation":[{"name":"Department of Oncology University of Calgary  Calgary Alberta Canada"},{"name":"Department of Surgery University of Calgary  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel L.","family":"Tremblay","sequence":"additional","affiliation":[{"name":"University of McGill  Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stein","family":"Kaasa","sequence":"additional","affiliation":[{"name":"Department of Cancer Research and Molecular Medicine Norwegian University of Science and Technology  Trondheim Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Strasser","sequence":"additional","affiliation":[{"name":"Department of Family Medicine and Emergency Medicine Laval University  Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Gagnon","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Cantonal Hospital  St. Gallen Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vickie E.","family":"Baracos","sequence":"additional","affiliation":[{"name":"Department of Oncology University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sambasivarao","family":"Damaraju","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth C.H.","family":"Fearon","sequence":"additional","affiliation":[{"name":"Department of Clinical and Surgical Sciences University of Edinburgh  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,8,5]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2012.209"},{"key":"e_1_2_10_3_1","first-page":"63","article-title":"Body composition in cancer cachexia","volume":"17","author":"Fearon KC","year":"1990","journal-title":"Infusionstherapie"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/emmm.201200231"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0022538"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/gm122"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201006098"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.07.011"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/82_2010_78"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2011.09.011"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1198973"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12041-011-0027-4"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12041-014-0405-9"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70218-7"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-09-1525"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-012-1581-5"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(08)70153-0"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.45.2722"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0083618"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/53.6.1493"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0065380"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1139\/H08-075"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-7-45"},{"key":"e_1_2_10_24_1","first-page":"41","article-title":"Interleukin\u20101 genetic polymorphisms and their relationship to the cancer anorexia\/weight loss syndrome in metastatic gastric and gastroesophageal junction adenocarcinoma","volume":"5","author":"Jatoi A","year":"2007","journal-title":"J Support Oncol"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2008.27025"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13539-012-0088-0"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/01213011-200503000-00006"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1086\/519795"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1089\/10665270360688192"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-14-997"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0108057"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13539-011-0030-x"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.3109\/10409238.2013.857291"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-11-2133"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.03-0610com"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80595-4"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiv197"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afu115"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12089"}],"container-title":["Journal of Cachexia, Sarcopenia and Muscle"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcsm.12138","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcsm.12138","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcsm.12138","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T07:00:04Z","timestamp":1696402804000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcsm.12138"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,5]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["10.1002\/jcsm.12138"],"URL":"https:\/\/doi.org\/10.1002\/jcsm.12138","archive":["Portico"],"relation":{},"ISSN":["2190-5991","2190-6009"],"issn-type":[{"value":"2190-5991","type":"print"},{"value":"2190-6009","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,5]]},"assertion":[{"value":"2016-01-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-06-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-08-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}