{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:11:34Z","timestamp":1792033894630,"version":"4.4.0"},"reference-count":51,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,11,28]],"date-time":"2016-11-28T00:00:00Z","timestamp":1480291200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"National Center for Tumor Diseases"},{"name":"Stiftung Leben mit Krebs"},{"name":"Manfred Lautenschlaeger Foundation"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Muscle dysfunction and sarcopenia have been associated with poor performance status, an increased mortality risk, and greater side effects in oncologic patients. However, little is known about how performance is affected by cancer therapy. We investigated muscle strength in breast cancer patients in different adjuvant treatment settings and also compared it with data from healthy individuals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Breast cancer patients (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u2009255) from two randomized controlled exercise trials, staged 0\u2013III and aged 54.4\u2009\u00b1\u20099.4\u2009years, were categorized into four groups according to their treatment status. In a cross\u2010sectional design, muscle function was assessed bilaterally by isokinetic dynamometry (0\u00b0, 60\u00b0, 180\u00b0\/s) as maximal voluntary isometric contraction (MVIC) and maximal isokinetic peak torque (MIPT) in shoulder rotators and knee flexors and extensors. Additionally, muscular fatigue index (FI%) and shoulder flexibility were evaluated. Healthy women (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u200926), aged 53.3\u2009\u00b1\u20099.8\u2009years, were tested using the same method. Analysis of covariance was used to estimate the impact of different cancer treatments on skeletal muscle function with adjustment for various clinical and socio\u2010demographic factors.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Consistently, lower muscle strength was measured in shoulder and knee strength in patients after chemotherapy. On average, patients had up to 25% lower strength in lower extremities and 12\u201316% in upper extremities in MVIC and MIPT during cancer treatment compared with healthy women. No substantial difference between patient groups in shoulder strength, but significantly lower shoulder flexibility in patients with radical mastectomy was measured. Chemotherapy\u2010treated patients had consistently higher FI%. No serious adverse events were reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Breast cancer patients showed markedly impaired muscle strength and joint dysfunctions before and after anticancer treatment. The significant differences between patients and healthy individuals underline the need of exercise therapy as early as possible in order to prevent or counteract the loss of muscle function after curative surgery as well as the consequences of neo\u2010\/adjuvant chemotherapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcsm.12165","type":"journal-article","created":{"date-parts":[[2016,11,28]],"date-time":"2016-11-28T23:19:53Z","timestamp":1480375193000},"page":"305-316","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":197,"title":["Muscle strength in breast cancer patients receiving different treatment regimes"],"prefix":"10.1002","volume":"8","author":[{"given":"Oliver","family":"Klassen","sequence":"first","affiliation":[{"name":"Division of Sports Therapy Hospital M\u00fcnsterland  Bad Rothenfelde Germany"},{"name":"Division of Physical Activity, Prevention and Cancer National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ)  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina E.","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Division of Physical Activity, Prevention and Cancer National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ)  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelia M.","family":"Ulrich","sequence":"additional","affiliation":[{"name":"Huntsman Cancer Center  Salt Lake City USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Schneeweiss","sequence":"additional","affiliation":[{"name":"Division of Gynecological Oncology National Center for Tumor Diseases (NCT) and University Hospital  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Potthoff","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology National Center for Tumor Diseases (NCT) and University Hospital  Heidelberg Germany"},{"name":"Division of Radiation Oncology National Center for Tumor Diseases (NCT) and University Hospital  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Steindorf","sequence":"additional","affiliation":[{"name":"Division of Physical Activity, Prevention and Cancer National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ)  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5971-5436","authenticated-orcid":false,"given":"Joachim","family":"Wiskemann","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology National Center for Tumor Diseases (NCT) and University Hospital  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,11,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11764-012-0234-x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdt551"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2012.27"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdu012"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1188\/08.ONF.815-821"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.9.2381"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2011.08.005"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-08-2242"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/61.1.72"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdm364"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.08.2024"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000000297"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e31829a3b63"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.3109\/0284186X.2014.899435"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-13-162"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cct.2012.10.006"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdu374"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1024\/1012-5302.14.3.161"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/85.5.365"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1016673003237"},{"key":"e_1_2_7_22_1","doi-asserted-by":"crossref","first-page":"149","DOI":"10.3233\/IES-2012-0451","article-title":"Reproducibility for isometric and isokinetic maximum knee flexion and extension measurements using the IsoMed 2000\u2010dynamometer","volume":"20","author":"Dirnberger J","year":"2012","journal-title":"Isokinet Exerc Sci"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2009-0265"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13539-010-0016-0"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/02841860802130001"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1021104"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-013-1894-4"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1159\/000358157"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11764-010-0168-0"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/pcan.2008.51"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-08-1075"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/787169"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-684X-7-3"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-002-0343-6"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002800000175"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.021774"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2011.3965"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.3109\/10409238.2013.857291"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(08)70153-0"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.7823"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2011.01.003"},{"key":"e_1_2_7_42_1","first-page":"251","article-title":"Sarcopenia: what's new in 2014","volume":"69","author":"Beaudart C","year":"2014","journal-title":"Rev Med Liege"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.59.1081"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2005.04.001"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djs207"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00566.2004"},{"key":"e_1_2_7_47_1","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1158\/1055-9965.1099.13.7","article-title":"Effect of exercise on serum androgens in postmenopausal women: a 12\u2010month randomized clinical trial","volume":"13","author":"McTiernan A","year":"2004","journal-title":"Cancer epidemiology, biomarkers & prevention : a publication of the Am Association for Cancer Res cosponsored by the Am Society of Preventive Oncol"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.27467"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-013-2509-y"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1991.71.2.644"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1159\/000331696"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12089"}],"container-title":["Journal of Cachexia, Sarcopenia and Muscle"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcsm.12165","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcsm.12165","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcsm.12165","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T18:53:44Z","timestamp":1696445624000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcsm.12165"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,28]]},"references-count":51,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["10.1002\/jcsm.12165"],"URL":"https:\/\/doi.org\/10.1002\/jcsm.12165","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.727062077.793528253","asserted-by":"object"}]},"ISSN":["2190-5991","2190-6009"],"issn-type":[{"value":"2190-5991","type":"print"},{"value":"2190-6009","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,28]]},"assertion":[{"value":"2016-01-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-10-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-11-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}