{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T14:04:56Z","timestamp":1791381896639,"version":"4.3.3"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The association between C\u2010reactive protein (CRP) level, symptoms, and activities of daily living (ADL) in advanced cancer patients is unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Secondary data analysis of a multicenter prospective cohort study consisted of 2426 advanced cancer patients referred to palliative care settings was conducted to examine the cross\u2010sectional relationships between CRP level, symptoms, and ADL disabilities. Laboratory data, symptoms, ADL, and manual muscle testing (MMT) results were obtained at baseline. Participants were divided into four groups: low (CRP\u00a0&lt;\u00a01\u00a0mg\/dl), moderate (1\u00a0=\u00a0&lt; CRP &lt;5\u00a0mg\/dl), high (5\u00a0=\u00a0&lt; CRP\u00a0&lt;\u00a010\u00a0mg\/dl), and very high CRP (10\u00a0mg\/dl\u00a0=\u00a0&lt; CRP). The proportions of eight symptoms, five ADL disabilities, and three categories of MMT according to the CRP groups were tested by chi\u2010square tests. Multiple\u2010adjusted odd ratios (ORs) were calculated by using ordinal logistic regression after adjustment for age, gender, site of primary cancer, metastatic disease, performance status, chemotherapy, and setting of care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 1702 patients were analysed. Positive rates of symptoms and ADL disabilities increased with increasing CRP level. In the very high\u2010CRP group, rates of positivity for anorexia, fatigue, and weight loss were 89.8%, 81.0%, and 79.2%, respectively, and over 70% of patients received assistance for bathing, dressing, going to the toilet, and transfer. The grade of MMT also deteriorated with increasing CRP level. Adjusted ORs for the accumulated symptoms significantly increased with increasing CRP level in the moderate\u2010CRP, high\u2010CRP, and very high\u2010CRP groups [1.6 (95% confidence interval 1.2\u20132.0),\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001; 2.5 (1.9\u20133.2),\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001; 3.5 (2.7\u20134.6),\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001, respectively]. Adjusted ORs for the accumulated ADL disabilities significantly increased in the very high\u2010CRP groups [2.1 (1.5\u20132.9),\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001].\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Associations between CRP level, symptoms, and ADL were observed in advanced cancer patients receiving palliative care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcsm.12184","type":"journal-article","created":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:17:55Z","timestamp":1488327475000},"page":"457-465","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":68,"title":["C\u2010reactive protein, symptoms and activity of daily living in patients with advanced cancer receiving palliative care"],"prefix":"10.1002","volume":"8","author":[{"given":"Koji","family":"Amano","sequence":"first","affiliation":[{"name":"Department of Palliative Medicine Osaka City General Hospital  2\u201013\u201022 Miyakojima\u2010hondori, Miyakojima\u2010ku Osaka City 534\u20100021 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isseki","family":"Maeda","sequence":"additional","affiliation":[{"name":"Department of Palliative Medicine, Graduate School of Medicine Osaka University  2\u20102 Yamadaoka Suita Osaka 565\u20100871 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Morita","sequence":"additional","affiliation":[{"name":"Palliative and Supportive Care Division Seirei Mikatahara General Hospital  3453 Mikatahara\u2010cho, Kita\u2010ku Hamamatsu Shizuoka 433\u20108558 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mika","family":"Baba","sequence":"additional","affiliation":[{"name":"Department of Palliative Care Saito Yukoukai Hospital  7\u20102\u201018 Saito Asagi Ibaragi Osaka 567\u20100085 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomofumi","family":"Miura","sequence":"additional","affiliation":[{"name":"Department of Palliative Medicine National Cancer Hospital East  6\u20105\u20101 Kashiwanoha Kashiwa Chibay 277\u20108577 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Hama","sequence":"additional","affiliation":[{"name":"Palliative Care Team Osaka Medical Center for Cancer and Cardiovascular Diseases  1\u20103\u20103 Nakamichi, Higashinari\u2010ku Osaka 537\u20108511 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ichiro","family":"Mori","sequence":"additional","affiliation":[{"name":"Gratia Hospital Hospice  6\u201014\u20101 Aomadaninishi Mino Osaka 562\u20108567 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuhisa","family":"Nakajima","sequence":"additional","affiliation":[{"name":"Department of Palliative Medicine, Graduate School of Medicine Tohoku University  1\u20101 Seiryo\u2010machi, Aobaku Sendai Miyagi 980\u20108574 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiro","family":"Nishi","sequence":"additional","affiliation":[{"name":"Kawasaki Comprehensive Care Center Kawasaki Municipal Ida Hospital  2\u201027\u20101 Ida Nakahara\u2010ku Kawasaki Kanagawa 211\u20100035 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Sakurai","sequence":"additional","affiliation":[{"name":"Department of Palliative Care St. Luke's International Hospital, Tokyo  9\u20101 Akashi\u2010cho Chuo\u2010ku Tokyo 104\u20108560 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satofumi","family":"Shimoyama","sequence":"additional","affiliation":[{"name":"Department of Palliative Care Aichi Cancer Center Hospital  1\u20101 Kanokoden, Chikusa\u2010ku Nagoya Aichi 464\u20108681 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuya","family":"Shinjo","sequence":"additional","affiliation":[{"name":"Shinjo Clinic, Kobe  1\u20105\u20101\u2010307 Kitagoyou, Kita\u2010ku Kobe Hyogo 651\u20101131 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroto","family":"Shirayama","sequence":"additional","affiliation":[{"name":"Osaka Kita Homecare Clinic Shin\u2010Osaka 3rd Doi\u2010biru 3F  1\u20108\u201024 Nisimiyahara Yodogawa\u2010ku Osaka 532\u20100004 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal and Hepato\u2010Biliary\u2010Pancreatic Surgery Nippon Medical School  1\u20101\u20105 Sendagi, Bunkyo\u2010ku Tokyo 113\u20108602 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeki","family":"Ono","sequence":"additional","affiliation":[{"name":"Division of Palliative Medicine Shizuoka Cancer Center Hospital  1007 Shimonagakubo, Nagaizumi\u2010cho, Suntou\u2010gun Shizuoka 411\u20108777 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taketoshi","family":"Ozawa","sequence":"additional","affiliation":[{"name":"Megumi Zaitaku Clinic  2\u20104\u20103 Hashido, Seya\u2010ku Yokohama Kanagawa 246\u20100037 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Palliative Medicine Saku Central Hospital Advanced Care Center  3400\u201028 Nakagomi Saku Nagano 385\u20100051 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