{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T07:46:43Z","timestamp":1792482403913,"version":"4.5.0"},"reference-count":52,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The control of muscle size is an essential feature of health. Indeed, skeletal muscle atrophy leads to reduced strength, poor quality of life, and metabolic disturbances. Consequently, strategies aiming to attenuate muscle wasting and to promote muscle growth during various (pathological) physiological states like sarcopenia, immobilization, malnutrition, or cachexia are needed to address this extensive health issue. In this study, we tested the effects of urolithin B, an ellagitannin\u2010derived metabolite, on skeletal muscle growth.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      C2C12 myotubes were treated with 15\u00a0\u03bcM of urolithin B for 24\u00a0h. For\n                      <jats:italic>in vivo<\/jats:italic>\n                      experiments, mice were implanted with mini\u2010osmotic pumps delivering continuously 10\u00a0\u03bcg\/day of urolithin B during 28\u00a0days. Muscle atrophy was studied in mice with a sciatic nerve denervation receiving urolithin B by the same way.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Our experiments reveal that urolithin B enhances the growth and differentiation of C2C12 myotubes by increasing protein synthesis and repressing the ubiquitin\u2013proteasome pathway. Genetic and pharmacological arguments support an implication of the androgen receptor. Signalling analyses suggest a crosstalk between the androgen receptor and the mTORC1 pathway, possibly via AMPK.\n                      <jats:italic>In vivo<\/jats:italic>\n                      experiments confirm that urolithin B induces muscle hypertrophy in mice and reduces muscle atrophy after the sciatic nerve section.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study highlights the potential usefulness of urolithin B for the treatment of muscle mass loss associated with various (pathological) physiological states.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcsm.12190","type":"journal-article","created":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T22:02:47Z","timestamp":1488405767000},"page":"583-597","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":69,"title":["Urolithin B, a newly identified regulator of skeletal muscle mass"],"prefix":"10.1002","volume":"8","author":[{"given":"Julie","family":"Rodriguez","sequence":"first","affiliation":[{"name":"Institute of Neuroscience Universit\u00e9 catholique de Louvain  1 place Pierre de Coubertin 1348 Louvain\u2010la\u2010Neuve Belgium"},{"name":"PROCELL nutrition sprl  2 Rue Jean Burgers 7850 Enghien Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Pierre","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience Universit\u00e9 catholique de Louvain  1 place Pierre de Coubertin 1348 Louvain\u2010la\u2010Neuve Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damien","family":"Naslain","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience Universit\u00e9 catholique de Louvain  1 place Pierre de Coubertin 1348 Louvain\u2010la\u2010Neuve Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7oise","family":"Bontemps","sequence":"additional","affiliation":[{"name":"De Duve Institute Universit\u00e9 catholique de Louvain  75 Avenue Hippocrate 1200 Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daneel","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Department of Biomolecular Sciences, Division of Pharmacognosy, Research Institute of Pharmaceutical Sciences University of Mississippi, Medicinal Plant Garden, RM 104, University  MS 38677 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabian","family":"Priem","sequence":"additional","affiliation":[{"name":"PROCELL nutrition sprl  2 Rue Jean Burgers 7850 Enghien Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise","family":"Deldicque","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience Universit\u00e9 catholique de Louvain  1 place Pierre de Coubertin 1348 Louvain\u2010la\u2010Neuve Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Francaux","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience Universit\u00e9 catholique de Louvain  1 place Pierre de Coubertin 1348 Louvain\u2010la\u2010Neuve Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2005.04.018"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf050384i"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf0723864"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf103894m"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/136.10.2481"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-004-0461-7"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/686921"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201100677"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2009.04.012"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2013.06.025"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e3181b64edd"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00394\u2010014\u20100717\u20109"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jobm.200510600"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.124.5.827"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.12.4.502"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.2.815"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.10-168799"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2014.00230"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2152"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(04)00400-3"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80595-4"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1065874"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2007.11.004"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2007.11.001"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2012.10.019"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-08-0225"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(96)80003-3"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/270418"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-014-1689-x"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114512003297"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.556241"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2011.03.020"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e31828cf5f3"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00402.2010"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2013-1004"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.24494"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2008-0664"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2008.03.024"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00490.2009"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1089\/dna.1988.7.27"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-6915(02)00066-2"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2013.06.010"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-020918"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00724.2007"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.399949"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.4161\/auto.5.2.7391"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1177\/153537020623100315"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.014126"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/micr.20392"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2014.05.143"},{"key":"e_1_2_8_52_1","article-title":"Endurance training attenuates catabolic signals induced by TNF\u2010\u03b1 in muscle of mice","author":"Rodriguez J","year":"2015","journal-title":"Med Sci Sports Exerc"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12089"}],"container-title":["Journal of Cachexia, Sarcopenia and Muscle"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcsm.12190","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcsm.12190","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T03:05:00Z","timestamp":1696388700000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcsm.12190"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":52,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["10.1002\/jcsm.12190"],"URL":"https:\/\/doi.org\/10.1002\/jcsm.12190","archive":["Portico"],"relation":{},"ISSN":["2190-5991","2190-6009"],"issn-type":[{"value":"2190-5991","type":"print"},{"value":"2190-6009","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3]]},"assertion":[{"value":"2016-04-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-01-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-03-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}