{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T16:14:47Z","timestamp":1792167287194,"version":"4.4.0"},"reference-count":69,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,4,5]],"date-time":"2017-04-05T00:00:00Z","timestamp":1491350400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>As muscle capillarization is related to the oxidative capacity of the muscle and the size of muscle fibres, capillary rarefaction may contribute to sarcopenia and functional impairment in older adults. Therefore, it is important to assess how ageing affects muscle capillarization and the interrelationship between fibre capillary supply with the oxidative capacity and size of the fibres.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Muscle biopsies from healthy recreationally active young (22\u00a0years; 14 men and 5 women) and older (74\u00a0years; 22 men and 6 women) people were assessed for muscle capillarization and the distribution of capillaries with the method of capillary domains. Oxidative capacity of muscle fibres was assessed with quantitative histochemistry for succinate dehydrogenase (SDH) activity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There was no significant age\u2010related reduction in muscle fibre oxidative capacity. Despite 18% type II fibre atrophy (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.019) and 23% fewer capillaries per fibre (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.002) in the old people, there was no significant difference in capillary distribution between young and old people, irrespective of sex. The capillary supply to a fibre was primarily determined by fibre size and only to a small extent by oxidative capacity, irrespective of age and sex. Based on SDH, the maximal oxygen consumption supported by a capillary did not differ significantly between young and old people.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The similar quantitative and qualitative distribution of capillaries within muscle from healthy recreationally active older people and young adults indicates that the age\u2010related capillary rarefaction, which does occur, nevertheless maintains the coupling between skeletal muscle fibre size and capillarization during healthy ageing.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcsm.12194","type":"journal-article","created":{"date-parts":[[2017,4,6]],"date-time":"2017-04-06T00:25:43Z","timestamp":1491438343000},"page":"647-659","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":94,"title":["Coupling between skeletal muscle fiber size and capillarization is maintained during healthy aging"],"prefix":"10.1002","volume":"8","author":[{"given":"Yoann","family":"Barnouin","sequence":"first","affiliation":[{"name":"School of Healthcare Science Manchester Metropolitan University  Chester Street Manchester M1 5GD UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie S.","family":"McPhee","sequence":"additional","affiliation":[{"name":"School of Healthcare Science Manchester Metropolitan University  Chester Street Manchester M1 5GD UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gillian","family":"Butler\u2010Browne","sequence":"additional","affiliation":[{"name":"Institut de Myologie, UPMC UM 76, INSERM U 974, CNRS UMR 7215 Pitle\u2010Salpetriere Hospital  47\u201083 Boulevard de l'Hopital 75013 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Bosutti","sequence":"additional","affiliation":[{"name":"School of Healthcare Science Manchester Metropolitan University  Chester Street Manchester M1 5GD UK"},{"name":"Istituto di Anatomia Patologica, Dipartimento di Scienze Mediche, Chirurgiche e della Salute University of Trieste, Cattinara Hospital  Strada di Fiume 447 34149 Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"De Vito","sequence":"additional","affiliation":[{"name":"Physiotherapy &amp; Sports Science, Health Sciences Centre School of Public Health  Belfield Dublin 4 D04 V1W8 Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Jones","sequence":"additional","affiliation":[{"name":"School of Healthcare Science Manchester Metropolitan University  Chester Street Manchester M1 5GD UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Narici","sequence":"additional","affiliation":[{"name":"Division of Medical Sciences &amp; Graduate Entry Medicine, School of Medicine, Faculty of Medicine &amp; Health Sciences, MRC\u2010ARUK Centre of Excellence for Musculoskeletal Ageing Research, Derby Royal Hospital University of Nottingham  Uttoxeter Road Derby DE22 3DT UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Behin","sequence":"additional","affiliation":[{"name":"AP\u2010HP\u2014Centre de R\u00e9f\u00e9rence de Pathologies Neuromusculaire Paris Est\u2014Institut de Myologie  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Yves","family":"Hogrel","sequence":"additional","affiliation":[{"name":"Institut de Myologie, UPMC UM 76, INSERM U 974, CNRS UMR 7215 Pitle\u2010Salpetriere Hospital  47\u201083 Boulevard de l'Hopital 75013 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Degens","sequence":"additional","affiliation":[{"name":"School of Healthcare Science Manchester Metropolitan University  Chester Street Manchester M1 5GD UK"},{"name":"Lithuanian Sports University  6 Sporto St LT\u201044221 Kaunas Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,4,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1992.72.2.369"},{"key":"e_1_2_9_3_1","first-page":"838","article-title":"Whey protein with potassium bicarbonate supplement attenuates the reduction in muscle oxidative capacity during 19\u00a0days of bed rest","volume":"121","author":"Bosutti A","year":"2016","journal-title":"J. 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