{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T07:39:29Z","timestamp":1789371569490,"version":"build-2803163510"},"reference-count":48,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,9,14]],"date-time":"2017-09-14T00:00:00Z","timestamp":1505347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Patients experiencing disuse atrophy report acute loss of skeletal muscle mass which subsequently leads to loss of strength and physical capacity. In such patients, especially the elderly, complete recovery remains a challenge even with improved nutrition and resistance exercise. This study aimed to explore the clinical potential of bimagrumab, a human monoclonal antibody targeting the activin type II receptor, for the recovery of skeletal muscle volume from disuse atrophy using an experimental model of lower extremity immobilization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this double\u2010blind, placebo\u2010controlled trial, healthy young men (<jats:italic>n<\/jats:italic>\u00a0=\u00a024; mean age, 24.1\u00a0years) were placed in a full\u2010length cast of one of the lower extremities for 2\u00a0weeks to induce disuse atrophy. After cast removal, subjects were randomized to receive a single intravenous (i.v.) dose of either bimagrumab 30\u00a0mg\/kg (<jats:italic>n<\/jats:italic>\u00a0=\u00a015) or placebo (<jats:italic>n<\/jats:italic>\u00a0=\u00a09) and were followed for 12\u00a0weeks. Changes in thigh muscle volume (TMV) and inter\u2010muscular adipose tissue (IMAT) and subcutaneous adipose tissue (SCAT) of the thigh, maximum voluntary knee extension strength, and safety were assessed throughout the 12 week study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Casting resulted in an average TMV loss of \u22124.8% and comparable increases in IMAT and SCAT volumes. Bimagrumab 30\u00a0mg\/kg i.v. resulted in a rapid increase in TMV at 2\u00a0weeks following cast removal and a +5.1% increase above pre\u2010cast levels at 12\u00a0weeks. In comparison, TMV returned to pre\u2010cast level at 12\u00a0weeks (\u22120.1%) in the placebo group. The increased adiposity of the casted leg was sustained in the placebo group and decreased substantially in the bimagrumab group at Week 12 (IMAT: \u22126.6%, SCAT: \u22123.5%). Knee extension strength decreased by ~25% in the casted leg for all subjects and returned to pre\u2010cast levels within 6\u00a0weeks after cast removal in both treatment arms. Bimagrumab was well tolerated with no serious or severe adverse events reported during the study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A single dose of bimagrumab 30\u00a0mg\/kg i.v. safely accelerated the recovery of TMV and reversal of accumulated IMAT following 2\u00a0weeks in a joint\u2010immobilizing cast.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcsm.12205","type":"journal-article","created":{"date-parts":[[2017,9,14]],"date-time":"2017-09-14T07:49:23Z","timestamp":1505375363000},"page":"727-734","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":88,"title":["Effect of bimagrumab on thigh muscle volume and composition in men with casting\u2010induced atrophy"],"prefix":"10.1002","volume":"8","author":[{"given":"Daniel S.","family":"Rooks","sequence":"first","affiliation":[{"name":"Translational Medicine Novartis Institutes for BioMedical Research  Cambridge MA 02139 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Laurent","sequence":"additional","affiliation":[{"name":"Translational Medicine Novartis Institutes for BioMedical Research  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Praestgaard","sequence":"additional","affiliation":[{"name":"Translational Medicine Novartis Institutes for BioMedical Research  Cambridge MA 02139 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Rasmussen","sequence":"additional","affiliation":[{"name":"Celerion Inc.  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