{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T11:58:17Z","timestamp":1790423897740,"version":"4.1.0"},"reference-count":179,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,7,3]],"date-time":"2017-07-03T00:00:00Z","timestamp":1499040000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The spectrum of activity of vitamin D goes beyond calcium and bone homeostasis, and growing evidence suggests that vitamin D contributes to maintain musculoskeletal health in healthy subjects as well as in patients with chronic kidney disease (CKD), who display the combination of bone metabolism disorder, muscle wasting, and weakness. Here, we review how vitamin D represents a pathway in which bone and muscle may interact.\n                    <jats:italic>In vitro<\/jats:italic>\n                    studies have confirmed that the vitamin D receptor is present on muscle, describing the mechanisms whereby vitamin D directly affects skeletal muscle. These include genomic and non\u2010genomic (rapid) effects, regulating cellular differentiation and proliferation. Observational studies have shown that circulating 25\u2010hydroxyvitamin D levels correlate with the clinical symptoms and muscle morphological changes observed in CKD patients. Vitamin D deficiency has been linked to low bone formation rate and bone mineral density, with an increased risk of skeletal fractures. The impact of low vitamin D status on skeletal muscle may also affect muscle metabolic pathways, including its sensitivity to insulin. Although some interventional studies have shown that vitamin D may improve physical performance and protect against the development of histological and radiological signs of hyperparathyroidism, evidence is still insufficient to draw definitive conclusions.\n                  <\/jats:p>","DOI":"10.1002\/jcsm.12218","type":"journal-article","created":{"date-parts":[[2017,7,4]],"date-time":"2017-07-04T09:16:04Z","timestamp":1499159764000},"page":"686-701","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":111,"title":["Vitamin D, a modulator of musculoskeletal health in chronic kidney disease"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8311-6214","authenticated-orcid":false,"given":"Pablo","family":"Molina","sequence":"first","affiliation":[{"name":"Department of Nephrology Hospital Universitario Doctor Peset  Valencia Spain"},{"name":"REDinREN  Madrid Spain"},{"name":"Department of Medicine Universitat de Val\u00e8ncia  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan J.","family":"Carrero","sequence":"additional","affiliation":[{"name":"Division of Renal Medicine CLINTEC, Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi","family":"Bover","sequence":"additional","affiliation":[{"name":"REDinREN  Madrid Spain"},{"name":"Department of Nephrology Fundaci\u00f3 Puigvert  Barcelona Spain"},{"name":"IIB Sant Pau  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Chauveau","sequence":"additional","affiliation":[{"name":"Service de N\u00e9phrologie Transplantation Dialyse Centre Hospitalier Universitaire de Bordeaux et Aurad\u2010Aquitaine  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandro","family":"Mazzaferro","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular, Respiratory, Nephrologic and Geriatric Sciences Sapienza University of Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo Ure\u00f1a","family":"Torres","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Dialysis Clinique du Landy, Ramsay\u2010G\u00e9n\u00e9rale de Sant\u00e9  Saint Ouen Paris France"},{"name":"Department of Renal Physiology Necker Hospital, University of Paris Descartes  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the European Renal Nutrition (ERN) and Chronic Kidney Disease\u2010Mineral and Bone Disorder (CKD\u2010MBD) Working Groups of the European Renal Association\u2013European Dialysis Transplant Association 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